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The analysis of FFPE tissue sections stained with haematoxylin and eosin (H&E) or immunohistochemistry (IHC) is an essential part of the pathologic assessment of surgically resected breast cancer specimens. IHC staining has been broadly…

Cervical Cancer continues to be the leading gynecological malignancy, posing a persistent threat to women's health on a global scale. Early screening via cytology Whole Slide Image (WSI) diagnosis is critical to prevent this Cancer…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Honglin Li , Yusuan Sun , Chenglu Zhu , Yunlong Zhang , Shichuan Zhang , Zhongyi Shui , Pingyi Chen , Jingxiong Li , Sunyi Zheng , Can Cui , Lin Yang

In medical imaging, access to data is commonly limited due to patient privacy restrictions and the issue that it can be difficult to acquire enough data in the case of rare diseases.[1] The purpose of this investigation was to develop a…

Computer Vision and Pattern Recognition · Computer Science 2024-03-29 John R. McNulty , Lee Kho , Alexandria L. Case , Charlie Fornaca , Drew Johnston , David Slater , Joshua M. Abzug , Sybil A. Russell

Universal, transferable whole-slide image (WSI) representations are central to computational pathology. Incorporating multiple markers (e.g., immunohistochemistry, IHC) alongside H&E enriches H&E-based features with diverse, biologically…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Yizhi Zhang , Lei Fan , Zhulin Tao , Donglin Di , Yang Song , Sidong Liu , Cong Cong

Evidence-based medicine promises to improve the quality of healthcare by empowering medical decisions and practices with the best available evidence. The rapid growth of medical evidence, which can be obtained from various sources, poses a…

What does it mean for a generative AI model to be explainable? The emergent discipline of explainable AI (XAI) has made great strides in helping people understand discriminative models. Less attention has been paid to generative models that…

Human-Computer Interaction · Computer Science 2022-02-11 Jiao Sun , Q. Vera Liao , Michael Muller , Mayank Agarwal , Stephanie Houde , Kartik Talamadupula , Justin D. Weisz

Immunohistochemistry (IHC) has transformed clinical pathology by enabling the visualization of specific proteins within tissue sections. However, traditional IHC requires one tissue section per stain, exhibits section-to-section…

Artificial intelligence (AI) technology enables a range of enhancements in computer-aided instruction, from accelerating the creation of teaching materials to customizing learning paths based on learner outcomes. However, ensuring the…

Computers and Society · Computer Science 2025-11-19 Christina Perdikoulias , Chad Vance , Stephen M. Watt

For diagnosing melanoma, hematoxylin and eosin (H&E) stained tissue slides remains the gold standard. These images contain quantitative information in different magnifications. In the present study, we investigated whether deep…

Tissues and Organs · Quantitative Biology 2019-04-15 Peizhen Xie , Ke Zuo , Yu Zhang , Fangfang Li , Mingzhu Yin , Kai Lu

Recent advances in deep learning and on-device inference could transform routine screening for skin cancers. Along with the anticipated benefits of this technology, potential dangers arise from unforeseen and inherent biases. A significant…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Ko Watanabe , Stanislav Frolov , Aya Hassan , David Dembinsky , Adriano Lucieri , Andreas Dengel

The rapid growth of generative AI has introduced new challenges in content moderation and digital forensics. In particular, benign AI-generated images can be paired with harmful or misleading text, creating difficult-to-detect misuse. This…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Xinlei Guan , David Arosemena , Tejaswi Dhandu , Kuan Huang , Meng Xu , Miles Q. Li , Bingyu Shen , Ruiyang Qin , Umamaheswara Rao Tida , Boyang Li

Development of artificial intelligence (AI) techniques in medical imaging requires access to large-scale and diverse datasets for training and evaluation. In dermatology, obtaining such datasets remains challenging due to significant…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Andrea Kim , Niloufar Saharkhiz , Elena Sizikova , Miguel Lago , Berkman Sahiner , Jana Delfino , Aldo Badano

The proliferation of generative video technologies has intensified the need for reliable methods to detect and characterize synthetic media. To address this challenge, we organized the \href{https://safe-video-2025.dsri.org}{SAFE: Synthetic…

Stain variations often decrease the generalization ability of deep learning based approaches in digital histopathology analysis. Two separate proposals, namely stain normalization (SN) and stain augmentation (SA), have been spotlighted to…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Yiqing Shen , Yulin Luo , Dinggang Shen , Jing Ke

Staining is critical to cell imaging and medical diagnosis, which is expensive, time-consuming, labor-intensive, and causes irreversible changes to cell tissues. Recent advances in deep learning enabled digital staining via supervised model…

Image and Video Processing · Electrical Eng. & Systems 2023-03-06 Ziwang Xu , Lanqing Guo , Shuyan Zhang , Alex C. Kot , Bihan Wen

Multiple stains are usually used to highlight biological substances in biomedical image analysis. To decompose multiple stains for co-localization quantification, blind source separation is usually performed. Prior model-based stain…

Image and Video Processing · Electrical Eng. & Systems 2021-02-16 Xingyu Li

Color inconsistency is an inevitable challenge in computational pathology, which generally happens because of stain intensity variations or sections scanned by different scanners. It harms the pathological image analysis methods, especially…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Bingchao Zhao , Jiatai Lin , Changhong Liang , Zongjian Yi , Xin Chen , Bingbing Li , Weihao Qiu , Danyi Li , Li Liang , Chu Han , Zaiyi Liu

Quality assurance is a critical but underexplored area in digital pathology, where even minor artifacts can have significant effects. Artifacts have been shown to negatively impact the performance of AI diagnostic models. In current…

Image and Video Processing · Electrical Eng. & Systems 2025-06-13 Meredith VandeHaar , M. Clinch , I. Yilmaz , M. A. Rahman , Y. Xiao , F. Dogany , H. M. Alazab , A. Nassar , Z. Akkus , B. Dangott

This study presents a novel approach for intelligent user interaction interface generation and optimization, grounded in the variational autoencoder (VAE) model. With the rapid advancement of intelligent technologies, traditional interface…

Human-Computer Interaction · Computer Science 2024-12-20 Runsheng Zhang , Shixiao Wang , Tianfang Xie , Shiyu Duan , Mengmeng Chen

Virtual staining leverages computer-aided techniques to transfer the style of histochemically stained tissue samples to other staining types. In virtual staining of pathological images, maintaining strict structural consistency is crucial,…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Bing Xiong , Yue Peng , RanRan Zhang , Fuqiang Chen , JiaYe He , Wenjian Qin