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Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Artificial Intelligence · Computer Science 2025-05-12 Lorenzo Di Fruscia , Jana Marie Weber

Currently, large language models (LLMs) predominantly focus on the text modality. To enable more natural human-AI interaction, speech LLMs are emerging, but building effective end-to-end speech LLMs remains challenging due to limited data…

Computation and Language · Computer Science 2026-04-14 Yan Zhou , Qingkai Fang , Yun Hong , Yang Feng

Pretraining on a large-scale corpus has become a standard method to build general language models (LMs). Adapting a model to new data distributions targeting different downstream tasks poses significant challenges. Naive fine-tuning may…

Computation and Language · Computer Science 2023-05-23 Wuyang Chen , Yanqi Zhou , Nan Du , Yanping Huang , James Laudon , Zhifeng Chen , Claire Cu

Planning for an upcoming project iteration (sprint) is one of the key activities in Scrum planning. In this paper, we present our work in progress on exploring the applicability of Large Language Models (LLMs) for solving this problem. We…

Software Engineering · Computer Science 2025-12-23 Yuwon Yoon , Kevin Iwan , Madeleine Zwart , Xiaohan Qin , Hina Lee , Maria Spichkova

Recently, recurrent large language models (Recurrent LLMs) with linear computational complexity have re-emerged as efficient alternatives to self-attention-based LLMs (Self-Attention LLMs), which have quadratic complexity. However,…

Computation and Language · Computer Science 2025-07-28 Kai Liu , Zhan Su , Peijie Dong , Fengran Mo , Jianfei Gao , ShaoTing Zhang , Kai Chen

Measuring the generalization ability of Large Language Models (LLMs) is challenging due to data contamination. As models grow and computation becomes cheaper, ensuring tasks and test cases are unseen during training phases will become…

Computation and Language · Computer Science 2025-07-09 Sougata Saha , Monojit Choudhury

Fine-tuning pre-trained foundational language models (FLM) for specific tasks is often impractical, especially for resource-constrained devices. This necessitates the development of a Lifelong Learning (L3) framework that continuously…

Computation and Language · Computer Science 2023-11-14 Aidin Shiri , Kaushik Roy , Amit Sheth , Manas Gaur

Proprietary Large Language Models (LLMs), such as ChatGPT, have garnered significant attention due to their exceptional capabilities in handling a diverse range of tasks. Recent studies demonstrate that open-sourced smaller foundational…

Computation and Language · Computer Science 2023-10-10 Yue Zhang , Leyang Cui , Deng Cai , Xinting Huang , Tao Fang , Wei Bi

Efficiently training large language models requires parallelizing across hundreds of hardware accelerators and invoking various compute and memory optimizations. When combined, many of these strategies have complex interactions regarding…

Machine Learning · Computer Science 2024-09-25 Johannes Hagemann , Samuel Weinbach , Konstantin Dobler , Maximilian Schall , Gerard de Melo

Large Language Models (LLMs) have demonstrated remarkable performance on various tasks, yet their ability to extract and internalize deeper insights from domain-specific datasets remains underexplored. In this study, we investigate how…

Computation and Language · Computer Science 2025-01-30 Pouya Pezeshkpour , Estevam Hruschka

The advancement of Large Language Models (LLMs) for domain applications in fields such as materials science and engineering depends on the development of fine-tuning strategies that adapt models for specialized, technical capabilities. In…

Computation and Language · Computer Science 2024-09-06 Wei Lu , Rachel K. Luu , Markus J. Buehler

This paper studies close-loop task planning, which refers to the process of generating a sequence of skills (a plan) to accomplish a specific goal while adapting the plan based on real-time observations. Recently, prompting Large Language…

Computation and Language · Computer Science 2024-07-25 Mengkang Hu , Yao Mu , Xinmiao Yu , Mingyu Ding , Shiguang Wu , Wenqi Shao , Qiguang Chen , Bin Wang , Yu Qiao , Ping Luo

Accurate load forecasting is crucial for maintaining the power balance between generators and consumers,particularly with the increasing integration of renewable energy sources, which introduce significant intermittent volatility. With the…

Systems and Control · Electrical Eng. & Systems 2024-09-04 Mingyang Gao , Suyang Zhou , Wei Gu , Zhi Wu , Haiquan Liu , Aihua Zhou

Multi-modal Large Language Model (MLLM) refers to a model expanded from a Large Language Model (LLM) that possesses the capability to handle and infer multi-modal data. Current MLLMs typically begin by using LLMs to decompose tasks into…

Computation and Language · Computer Science 2023-09-01 Yongqiang Zhao , Zhenyu Li , Feng Zhang , Xinhai Xu , Donghong Liu

Several recent works seek to adapt general-purpose large language models (LLMs) and vision-language models (VLMs) for medical applications through continued pretraining on publicly available biomedical corpora. These works typically claim…

Computation and Language · Computer Science 2025-07-01 Daniel P. Jeong , Pranav Mani , Saurabh Garg , Zachary C. Lipton , Michael Oberst

Large Language Models (LLMs) recently achieved great success in medical text summarization by simply using in-context learning. However, these recent efforts do not perform fine-grained evaluations under difficult settings where LLMs might…

Computation and Language · Computer Science 2026-04-22 Gunjan Balde , Soumyadeep Roy , Mainack Mondal , Niloy Ganguly

Active learning (AL) accelerates scientific discovery by prioritizing the most informative experiments, but traditional machine learning (ML) models used in AL suffer from cold-start limitations and domain-specific feature engineering,…

Machine Learning · Computer Science 2025-12-05 Hongchen Wang , Rafael Espinosa Castañeda , Jay R. Werber , Yao Fehlis , Edward Kim , Jason Hattrick-Simpers

Large Language Models (LLMs) have shown promise in highly-specialized domains, however challenges are still present in aspects of accuracy and costs. These limitations restrict the usage of existing models in domain-specific tasks. While…

Computation and Language · Computer Science 2024-10-30 Iftach Arbel , Yehonathan Refael , Ofir Lindenbaum

In this work, we introduce EMMA-500, a large-scale multilingual language model continue-trained on texts across 546 languages designed for enhanced multilingual performance, focusing on improving language coverage for low-resource…

Computation and Language · Computer Science 2025-12-05 Shaoxiong Ji , Zihao Li , Jaakko Paavola , Peiqin Lin , Pinzhen Chen , Dayyán O'Brien , Hengyu Luo , Hinrich Schütze , Jörg Tiedemann , Barry Haddow

Large language models (LLMs) possess broad world knowledge and strong general-purpose reasoning ability, yet they struggle to learn from many in-context examples on standard machine learning (ML) tasks, that is, to leverage many-shot…

Computation and Language · Computer Science 2026-04-14 Haoyu Dong , Pengkun Zhang , Mingzhe Lu , Yanzhen Shen , Guolin Ke
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