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Disease heterogeneity has been a critical challenge for precision diagnosis and treatment, especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple distinct brain phenotypes across individuals, potentially…

The alignment of serial-section electron microscopy (ssEM) images is critical for efforts in neuroscience that seek to reconstruct neuronal circuits. However, each ssEM plane contains densely packed structures that vary from one section to…

Computer Vision and Pattern Recognition · Computer Science 2017-12-06 Inwan Yoo , David G. C. Hildebrand , Willie F. Tobin , Wei-Chung Allen Lee , Won-Ki Jeong

Background: Alzheimers disease is a progressive neurodegenerative disorder and the main cause of dementia in aging. Hippocampus is prone to changes in the early stages of Alzheimers disease. Detection and observation of the hippocampus…

Image and Video Processing · Electrical Eng. & Systems 2021-06-17 Hossein Yousefi-Banaem , Saber Malekzadeh

The Disrupted in Schizophrenia Gene 1 (DISC1) plays a role in both neural signalling and development and is associated with schizophrenia, although its links to altered brain structure and function in this disorder are not fully…

Neurons and Cognition · Quantitative Biology 2014-06-10 Xiaohong Gong , Wenlian Lu , Keith M. Kendrick , Weidan Pu , Chu Wang , Li Jin , Guangmin Lu , Zhening Liu , Haihong Liu , Jianfeng Feng

Bipolar disorder (BD) and schizophrenia (SZ) are severe mental disorders with profound societal impact. Identifying risk markers early is crucial for understanding disease progression and enabling preventive measures. The Danish High Risk…

Computer Vision and Pattern Recognition · Computer Science 2024-03-25 Vladyslav Zalevskyi , Kristoffer Hougaard Madsen

The development of diagnostic models is gaining traction in the field of psychiatric disorders. Recently, machine learning classifiers based on resting-state functional magnetic resonance imaging (rs-fMRI) have been developed to identify…

Machine Learning · Computer Science 2025-10-06 Tianzheng Hu , Qiang Li , Shu Liu , Vince D. Calhoun , Guido van Wingen , Shujian Yu

Resting state electroencephalogram (EEG) abnormalities in clinically high-risk individuals (CHR), clinically stable first-episode patients with schizophrenia (FES), healthy controls (HC) suggest alterations in neural oscillatory activity.…

Signal Processing · Electrical Eng. & Systems 2018-01-18 Haichun Liu , TianHong Zhang , Yumeng Ye , Changchun Pan , Genke Yang , JiJun Wang , Robert C. Qiu

Change detection is a key task in Earth observation applications. Recently, deep learning methods have demonstrated strong performance and widespread application. However, change detection faces data scarcity due to the labor-intensive…

Computer Vision and Pattern Recognition · Computer Science 2025-03-27 Ziyu Zhou , Keyan Hu , Yutian Fang , Xiaoping Rui

Single-cell RNA sequencing (scRNA-seq) has revolutionized biological discovery, providing an unbiased picture of cellular heterogeneity in tissues. While scRNA-seq has been used extensively to provide insight into both healthy systems and…

Genomics · Quantitative Biology 2020-03-16 Neal G. Ravindra , Arijit Sehanobish , Jenna L. Pappalardo , David A. Hafler , David van Dijk

Accurate diagnosis of psychiatric disorders plays a critical role in improving the quality of life for patients and potentially supports the development of new treatments. Many studies have been conducted on machine learning techniques that…

Machine Learning · Statistics 2019-04-15 Takashi Matsubara , Tetsuo Tashiro , Kuniaki Uehara

We consider two biologically plausible structures, the Spiking Neural Network (SNN) and the self-attention mechanism. The former offers an energy-efficient and event-driven paradigm for deep learning, while the latter has the ability to…

Neural and Evolutionary Computing · Computer Science 2022-11-23 Zhaokun Zhou , Yuesheng Zhu , Chao He , Yaowei Wang , Shuicheng Yan , Yonghong Tian , Li Yuan

Triggered by the success of transformers in various visual tasks, the spatial self-attention mechanism has recently attracted more and more attention in the computer vision community. However, we empirically found that a typical vision…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Jiayin Sun , Hong Wang , Qiulei Dong

Autism spectrum disorder (ASD) is a highly disabling mental disease that brings significant impairments of social interaction ability to the patients, making early screening and intervention of ASD critical. With the development of the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Ruimin Ma , Ruitao Xie , Yanlin Wang , Jintao Meng , Yanjie Wei , Wenhui Xi , Yi Pan

Structural MRI and PET imaging play an important role in the diagnosis of Alzheimer's disease (AD), showing the morphological changes and glucose metabolism changes in the brain respectively. The manifestations in the brain image of some…

Image and Video Processing · Electrical Eng. & Systems 2023-08-11 Yanteng Zhang , Qizhi Teng , Xiaohai He , Tong Niu , Lipei Zhang , Yan Liu , Chao Ren

Deep learning has been successfully applied to recognizing both natural images and medical images. However, there remains a gap in recognizing 3D neuroimaging data, especially for psychiatric diseases such as schizophrenia and depression…

Image and Video Processing · Electrical Eng. & Systems 2022-11-23 Mengjiao Hu , Xudong Jiang , Kang Sim , Juan Helen Zhou , Cuntai Guan

Recent advancements in neuroscience research have propelled the development of Spiking Neural Networks (SNNs), which not only have the potential to further advance neuroscience research but also serve as an energy-efficient alternative to…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Yimeng Shan , Malu Zhang , Rui-jie Zhu , Xuerui Qiu , Jason K. Eshraghian , Haicheng Qu

Normative modeling enables individualized characterization of structural brain deviations by evaluating subjects against a reference population rather than a group average. Most existing implementations treat brain regions independently and…

Methodology · Statistics 2026-05-19 J. T. Korley

Dementia, a debilitating neurological condition affecting millions worldwide, presents significant diagnostic challenges. In this work, we introduce DEFORMISE, a novel DEep learning Framework for dementia diagnOsis of eldeRly patients using…

Image and Video Processing · Electrical Eng. & Systems 2025-11-21 Nikolaos Ntampakis , Konstantinos Diamantaras , Ioanna Chouvarda , Vasileios Argyriou , Panagiotis Sarigianndis

Single subject prediction of brain disorders from neuroimaging data has gained increasing attention in recent years. Yet, for some heterogeneous disorders such as major depression disorder (MDD) and autism spectrum disorder (ASD), the…

Machine Learning · Computer Science 2022-06-08 Ahmed El Gazzar , Rajat Mani Thomas , Guido Van Wingen

Single-subject mapping of resting-state brain functional activity to non-imaging phenotypes is a major goal of neuroimaging. The large majority of learning approaches applied today rely either on static representations or on short-term…

Machine Learning · Computer Science 2022-08-09 Ahmed El-Gazzar , Rajat Mani Thomas , Guido Van Wingen