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We present a novel diffusion-based approach to generate synthetic histopathological Whole Slide Images (WSIs) at an unprecedented gigapixel scale. Synthetic WSIs have many potential applications: They can augment training datasets to…

Image and Video Processing · Electrical Eng. & Systems 2023-11-15 Robert Harb , Thomas Pock , Heimo Müller

Whole slide images (WSIs) enable weakly supervised prognostic modeling via multiple instance learning (MIL). Spatial transcriptomics (ST) preserves in situ gene expression, providing a spatial molecular context that complements morphology.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Lihe Liu , Xiaoxi Pan , Yinyin Yuan , Lulu Shang

The annotation of large scale histopathology image datasets remains a major bottleneck in developing robust deep learning models for clinically relevant tasks, such as mitotic figure classification. Folder-based annotation workflows are…

The last decade has seen significant advances in computer-aided diagnostics for cytological screening, mainly through the improvement and integration of scanning techniques such as whole slide imaging (WSI) and the combination with deep…

Signal Processing · Electrical Eng. & Systems 2026-01-23 Philip Groult , Julia D. Sistermanns , Ellen Emken , Oliver Hayden , Wolfgang Utschick

In digital pathology, Whole Slide Image (WSI) analysis is usually formulated as a Multiple Instance Learning (MIL) problem. Although transformer-based architectures have been used for WSI classification, these methods require modifications…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Juan I. Pisula , Katarzyna Bozek

We propose DiRL, a Diversity-inducing Representation Learning technique for histopathology imaging. Self-supervised learning techniques, such as contrastive and non-contrastive approaches, have been shown to learn rich and effective…

Computer Vision and Pattern Recognition · Computer Science 2023-09-13 Saarthak Kapse , Srijan Das , Jingwei Zhang , Rajarsi R. Gupta , Joel Saltz , Dimitris Samaras , Prateek Prasanna

Extracting rich phenotype information, such as cell density and arrangement, from whole slide histology images (WSIs), requires analysis of large field of view, i.e more contexual information. This can be achieved through analyzing the…

Computer Vision and Pattern Recognition · Computer Science 2022-03-30 Saarthak Kapse , Srijan Das , Prateek Prasanna

Whole Slide Imaging (WSI) has become a gold standard in cancer diagnosis, inspecting multi-scale information from cellular to tissue levels. Processing an entire WSI directly is infeasible due to GPU memory constraints; thus, Multiple…

Image and Video Processing · Electrical Eng. & Systems 2026-05-08 Tianyi Zhang , Sicheng Chen , Borui Kang , Dankai Liao , Qiaochu Xue , Bochong Zhang , Fei Xia , Zeyu Liu , Yueming Jin

3D spatial perception is the problem of building and maintaining an actionable and persistent representation of the environment in real-time using sensor data and prior knowledge. Despite the fast-paced progress in robot perception, most…

Robotics · Computer Science 2023-05-15 Nathan Hughes , Yun Chang , Siyi Hu , Rajat Talak , Rumaisa Abdulhai , Jared Strader , Luca Carlone

Arbitrary text appearance poses a great challenge in scene text recognition tasks. Existing works mostly handle with the problem in consideration of the shape distortion, including perspective distortions, line curvature or other style…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Chengwei Zhang , Yunlu Xu , Zhanzhan Cheng , Shiliang Pu , Yi Niu , Fei Wu , Futai Zou

While Multiple Instance Learning (MIL) has shown promising results in digital Pathology Whole Slide Image (WSI) classification, such a paradigm still faces performance and generalization problems due to challenges in high computational…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Honglin Li , Chenglu Zhu , Yunlong Zhang , Yuxuan Sun , Zhongyi Shui , Wenwei Kuang , Sunyi Zheng , Lin Yang

We developed a software pipeline for quality control (QC) of histopathology whole slide images (WSIs) that segments various regions, such as blurs of different levels, tissue regions, tissue folds, and pen marks. Given the necessity and…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Abhijeet Patil , Garima Jain , Harsh Diwakar , Jay Sawant , Tripti Bameta , Swapnil Rane , Amit Sethi

Whole slide image (WSI) analysis has become increasingly important in the medical imaging community, enabling automated and objective diagnosis, prognosis, and therapeutic-response prediction. However, in clinical practice, the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-28 Yanyan Huang , Weiqin Zhao , Shujun Wang , Yu Fu , Yuming Jiang , Lequan Yu

Cancer survival prediction is a challenging task that involves analyzing of the tumor microenvironment within Whole Slide Image (WSI). Previous methods cannot effectively capture the intricate interaction features among instances within the…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Zekang Yang , Hong Liu , Xiangdong Wang

Subspace clustering is a powerful unsupervised approach for hyperspectral image (HSI) analysis, but its high computational and memory costs limit scalability. Superpixel segmentation can improve efficiency by reducing the number of data…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Xianlu Li , Nicolas Nadisic , Shaoguang Huang , Aleksandra Pizurica

Vision Transformers (ViTs) and their multi-scale and hierarchical variations have been successful at capturing image representations but their use has been generally studied for low-resolution images (e.g. - 256x256, 384384). For gigapixel…

Computer Vision and Pattern Recognition · Computer Science 2022-06-07 Richard J. Chen , Chengkuan Chen , Yicong Li , Tiffany Y. Chen , Andrew D. Trister , Rahul G. Krishnan , Faisal Mahmood

We propose a Hierarchical Multi-scale Knowledge-aware Graph Network (HMKGN) that models multi-scale interactions and spatially hierarchical relationships within whole-slide images (WSIs) for cancer prognostication. Unlike conventional…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Bin Xu , Yufei Zhou , Boling Song , Jingwen Sun , Yang Bian , Cheng Lu , Ye Wu , Jianfei Tu , Xiangxue Wang

The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via self-supervised learning…

In pre-clinical pathology, there is a paradox between the abundance of raw data (whole slide images from many organs of many individual animals) and the lack of pixel-level slide annotations done by pathologists. Due to time constraints and…

Computer Vision and Pattern Recognition · Computer Science 2023-02-06 Marco Bertolini , Van-Khoa Le , Jake Pencharz , Andreas Poehlmann , Djork-Arné Clevert , Santiago Villalba , Floriane Montanari

Automatic medical image segmentation has wide applications for disease diagnosing. However, it is much more challenging than natural optical image segmentation due to the high-resolution of medical images and the corresponding huge…

Computer Vision and Pattern Recognition · Computer Science 2020-12-18 Ziqiang Li , Rentuo Tao , Qianrun Wu , Bin Li