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Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

The widespread adoption of electronic health records and digital healthcare data has created a demand for data-driven insights to enhance patient outcomes, diagnostics, and treatments. However, using real patient data presents privacy and…

Machine Learning · Computer Science 2023-11-15 Aryan Jadon , Shashank Kumar

This paper presents a comprehensive systematic review of generative models (GANs, VAEs, DMs, and LLMs) used to synthesize various medical data types, including imaging (dermoscopic, mammographic, ultrasound, CT, MRI, and X-ray), text,…

Access to individual-level health data is essential for gaining new insights and advancing science. In particular, modern methods based on artificial intelligence rely on the availability of and access to large datasets. In the health…

Class imbalance can often degrade predictive performance of supervised learning algorithms. Balanced classes can be obtained by oversampling exact copies, with noise, or interpolation between nearest neighbours (as in traditional SMOTE…

Machine Learning · Computer Science 2022-01-17 Emily Muller , Xu Zheng , Jer Hayes

Acquiring large quantities of data and annotations is known to be effective for developing high-performing deep learning models, but is difficult and expensive to do in the healthcare context. Adding synthetic training data using generative…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Menghan Yu , Sourabh Kulhare , Courosh Mehanian , Charles B Delahunt , Daniel E Shea , Zohreh Laverriere , Ishan Shah , Matthew P Horning

Generative models capable of capturing nuanced clinical features in medical images hold great promise for facilitating clinical data sharing, enhancing rare disease datasets, and efficiently synthesizing annotated medical images at scale.…

Image and Video Processing · Electrical Eng. & Systems 2023-06-23 Shenghuan Sun , Gregory M. Goldgof , Atul Butte , Ahmed M. Alaa

The usage of medical image data for the training of large-scale machine learning approaches is particularly challenging due to its scarce availability and the costly generation of data annotations, typically requiring the engagement of…

Computer Vision and Pattern Recognition · Computer Science 2024-06-26 Joshua Niemeijer , Jan Ehrhardt , Hristina Uzunova , Heinz Handels

Generating clinical synthetic text represents an effective solution for common clinical NLP issues like sparsity and privacy. This paper aims to conduct a systematic review on generating synthetic medical free-text by formulating…

Computation and Language · Computer Science 2025-07-25 Basel Alshaikhdeeb , Ahmed Abdelmonem Hemedan , Soumyabrata Ghosh , Irina Balaur , Venkata Satagopam

Deep generative models and synthetic medical data have shown significant promise in addressing key challenges in healthcare, such as privacy concerns, data bias, and the scarcity of realistic datasets. While research in this area has grown…

Machine Learning · Computer Science 2025-02-05 Krishan Agyakari Raja Babu , Supriti Mulay , Om Prabhu , Mohanasankar Sivaprakasam

Accurate classification of clinical text often requires fine-tuning pre-trained language models, a process that is costly and time-consuming due to the need for high-quality data and expert annotators. Synthetic data generation offers an…

Computation and Language · Computer Science 2025-01-28 Ivan Lopez , Fateme Nateghi Haredasht , Kaitlin Caoili , Jonathan H Chen , Akshay Chaudhari

The generation of synthetic medical records using Generative Adversarial Networks (GANs) is becoming crucial for addressing privacy concerns and facilitating data sharing in the medical domain. In this paper, we introduce a novel method to…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Tomohiro Kikuchi , Shouhei Hanaoka , Takahiro Nakao , Tomomi Takenaga , Yukihiro Nomura , Harushi Mori , Takeharu Yoshikawa

Comprehensive clinical documentation is crucial for effective healthcare delivery, yet it poses a significant burden on healthcare professionals, leading to burnout, increased medical errors, and compromised patient safety. This paper…

Artificial Intelligence · Computer Science 2024-05-29 Anjanava Biswas , Wrick Talukdar

Recent advances in deep generative models have greatly expanded the potential to create realistic synthetic health datasets. These synthetic datasets aim to preserve the characteristics, patterns, and overall scientific conclusions derived…

Machine Learning · Computer Science 2024-07-04 Jennifer A Bartell , Sander Boisen Valentin , Anders Krogh , Henning Langberg , Martin Bøgsted

Access to high-quality medical data is often restricted due to privacy concerns, posing significant challenges for training artificial intelligence (AI) algorithms within Electronic Health Record (EHR) applications. In this study, prompt…

Artificial Intelligence · Computer Science 2025-04-30 Polycarp Nalela

Synthetic data generation, a cornerstone of Generative Artificial Intelligence, promotes a paradigm shift in data science by addressing data scarcity and privacy while enabling unprecedented performance. As synthetic data becomes more…

Machine Learning · Statistics 2024-03-12 Xiaotong Shen , Yifei Liu , Rex Shen

Access to electronic health records (EHRs) for digital health research is often limited by privacy regulations and institutional barriers. Synthetic EHRs have been proposed as a way to enable safe and sovereign data sharing; however,…

Machine Learning · Computer Science 2026-03-10 Guanglin Zhou , Armin Catic , Motahare Shabestari , Matthew Young , Chaiquan Li , Katrina Poppe , Sebastiano Barbieri

Synthetic data serves as an alternative in training machine learning models, particularly when real-world data is limited or inaccessible. However, ensuring that synthetic data mirrors the complex nuances of real-world data is a challenging…

Machine Learning · Computer Science 2023-10-27 Lasse Hansen , Nabeel Seedat , Mihaela van der Schaar , Andrija Petrovic

The limited data availability due to strict privacy regulations and significant resource demands severely constrains biomedical time-series AI development, which creates a critical gap between data requirements and accessibility. Synthetic…

Machine Learning · Computer Science 2025-11-25 Youngjoon Lee , Seongmin Cho , Yehhyun Jo , Jinu Gong , Hyunjoo Jenny Lee , Joonhyuk Kang

Analyzing medical data to find abnormalities is a time-consuming and costly task, particularly for rare abnormalities, requiring tremendous efforts from medical experts. Artificial intelligence has become a popular tool for the automatic…

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