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The integration of multi-omics single-cell data remains challenging due to high-dimensionality and complex inter-modality relationships. To address this, we introduce MoRE-GNN (Multi-omics Relational Edge Graph Neural Network), a…

Machine Learning · Computer Science 2025-10-09 Zhiyu Wang , Sonia Koszut , Pietro Liò , Francesco Ceccarelli

With the development of autonomous driving, it is becoming increasingly common for autonomous vehicles (AVs) and human-driven vehicles (HVs) to travel on the same roads. Existing single-vehicle planning algorithms on board struggle to…

Robotics · Computer Science 2023-02-15 Licheng Wen , Pinlong Cai , Daocheng Fu , Song Mao , Yikang Li

The rapid advancement of high-throughput sequencing and other assay technologies has resulted in the generation of large and complex multi-omics datasets, offering unprecedented opportunities for advancing precision medicine strategies.…

Quantitative Methods · Quantitative Biology 2025-01-30 Ana R. Baião , Zhaoxiang Cai , Rebecca C Poulos , Phillip J. Robinson , Roger R Reddel , Qing Zhong , Susana Vinga , Emanuel Gonçalves

Molecular representation learning is pivotal in predicting molecular properties and advancing drug design. Traditional methodologies, which predominantly rely on homogeneous graph encoding, are limited by their inability to integrate…

Machine Learning · Computer Science 2025-03-24 Mukun Chen , Jia Wu , Shirui Pan , Fu Lin , Bo Du , Xiuwen Gong , Wenbin Hu

We focus on the extension of bivariate causal learning methods into multivariate problem settings in a systematic manner via a novel framework. It is purposive to augment the scale to which bivariate causal discovery approaches can be…

Methodology · Statistics 2023-05-29 Hongyi Chen , Maurits Kaptein

Cross-modal retrieval is to utilize one modality as a query to retrieve data from another modality, which has become a popular topic in information retrieval, machine learning, and database. How to effectively measure the similarity between…

Information Retrieval · Computer Science 2021-12-07 Jiwei Zhang , Yi Yu , Suhua Tang , Jianming Wu , Wei Li

With the advancement of high-throughput biotechnologies, we increasingly accumulate biomedical data about diseases, especially cancer. There is a need for computational models and methods to sift through, integrate, and extract new…

Quantitative Methods · Quantitative Biology 2020-07-03 Thomas Gaudelet , Noel Malod-Dognin , Natasa Przulj

Survival analysis stands as a pivotal process in cancer treatment research, crucial for predicting patient survival rates accurately. Recent advancements in data collection techniques have paved the way for enhancing survival predictions by…

Machine Learning · Computer Science 2024-07-26 Linhao Qu , Dan Huang , Shaoting Zhang , Xiaosong Wang

Single-cell data analysis has the potential to revolutionize personalized medicine by characterizing disease-associated molecular changes at the single-cell level. Advanced single-cell multimodal assays can now simultaneously measure…

Quantitative Methods · Quantitative Biology 2026-01-05 Ali Anaissi , Seid Miad Zandavi , Weidong Huang , Junaid Akram , Basem Suleiman , Ali Braytee , Jie Hua

The fusion of complementary multimodal information is crucial in computational pathology for accurate diagnostics. However, existing multimodal learning approaches necessitate access to users' raw data, posing substantial privacy risks.…

Computer Vision and Pattern Recognition · Computer Science 2024-02-27 Yuanzhe Peng , Jieming Bian , Jie Xu

Most of the existing bi-modal (RGB-D and RGB-T) salient object detection methods utilize the convolution operation and construct complex interweave fusion structures to achieve cross-modal information integration. The inherent local…

Computer Vision and Pattern Recognition · Computer Science 2023-02-17 Youwei Pang , Xiaoqi Zhao , Lihe Zhang , Huchuan Lu

Goal-directed molecular generation requires satisfying heterogeneous constraints such as protein--ligand compatibility and multi-objective drug-like properties, yet existing methods often optimize these constraints in isolation, failing to…

Machine Learning · Computer Science 2026-04-14 Yanting Li , Zhuoyang Jiang , Enyan Dai , Lei Wang , Wen-Cai Ye , Li Liu

Multi-modal understanding plays a crucial role in artificial intelligence by enabling models to jointly interpret inputs from different modalities. However, conventional approaches such as contrastive learning often struggle with modality…

Machine Learning · Computer Science 2026-04-17 Jungkyoo Shin , Bumsoo Kim , Eunwoo Kim

Multimodal learning aims to discover the relationship between multiple modalities. It has become an important research topic due to extensive multimodal applications such as cross-modal retrieval. This paper attempts to address the modality…

Machine Learning · Computer Science 2019-08-15 Guoli Song , Shuhui Wang , Qingming Huang , Qi Tian

Jointly harnessing complementary features of multi-modal input data in a common latent space has been found to be beneficial long ago. However, the influence of each modality on the models decision remains a puzzle. This study proposes a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-06 Burak Ekim , Michael Schmitt

This study introduces a novel theoretical framework, the Stacked Autoencoder Evolution Hypothesis, which proposes that biological evolutionary systems operate through multi-layered self-encoding and decoding processes, analogous to stacked…

Neural and Evolutionary Computing · Computer Science 2026-02-03 Hiroyuki Iizuka

Multi-modal learning relates information across observation modalities of the same physical phenomenon to leverage complementary information. Most multi-modal machine learning methods require that all the modalities used for training are…

Machine Learning · Computer Science 2021-03-10 Vandana Rajan , Alessio Brutti , Andrea Cavallaro

Graphical causal models are an important tool for knowledge discovery because they can represent both the causal relations between variables and the multivariate probability distributions over the data. Once learned, causal graphs can be…

Artificial Intelligence · Computer Science 2017-04-11 Andrew J Sedgewick , Joseph D. Ramsey , Peter Spirtes , Clark Glymour , Panayiotis V. Benos

Devising deep latent variable models for multi-modal data has been a long-standing theme in machine learning research. Multi-modal Variational Autoencoders (VAEs) have been a popular generative model class that learns latent representations…

Machine Learning · Statistics 2024-09-25 Marcel Hirt , Domenico Campolo , Victoria Leong , Juan-Pablo Ortega

While graphical models for continuous data (Gaussian graphical models) and discrete data (Ising models) have been extensively studied, there is little work on graphical models linking both continuous and discrete variables (mixed data),…

Machine Learning · Statistics 2016-08-22 Jie Cheng , Tianxi Li , Elizaveta Levina , Ji Zhu