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Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Despite recent molecular technique improvements, biological knowledge remains incomplete. Reasoning on living systems hence implies to integrate heterogeneous and partial informations. Although current investigations successfully focus on…

Quantitative Methods · Quantitative Biology 2009-09-29 Jérémie Bourdon , Damien Eveillard , Samuel Gabillard , Theo Merle

Multimodal learning typically relies on the assumption that all modalities are fully available during both the training and inference phases. However, in real-world scenarios, consistently acquiring complete multimodal data presents…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Donggeun Kim , Taesup Kim

Recent works in multimodal recommendations, which leverage diverse modal information to address data sparsity and enhance recommendation accuracy, have garnered considerable interest. Two key processes in multimodal recommendations are…

Information Retrieval · Computer Science 2025-05-23 Jinfeng Xu , Zheyu Chen , Wei Wang , Xiping Hu , Sang-Wook Kim , Edith C. H. Ngai

Single-cell technologies enable comprehensive profiling of diverse immune cell-types through the measurement of multiple genes or proteins per individual cell. In order to translate immune signatures assayed from blood or tissue into…

Machine Learning · Computer Science 2024-11-26 Chi-Jane Chen , Haidong Yi , Natalie Stanley

Efficient similarity retrieval from large-scale multimodal database is pervasive in modern search engines and social networks. To support queries across content modalities, the system should enable cross-modal correlation and…

Information Retrieval · Computer Science 2016-05-24 Mingsheng Long , Yue Cao , Jianmin Wang , Philip S. Yu

Persistent homology is a powerful tool for characterizing the topology of a data set at various geometric scales. When applied to the description of molecular structures, persistent homology can capture the multiscale geometric features and…

Quantitative Methods · Quantitative Biology 2018-07-31 Zixuan Cang , Guo-Wei Wei

Histopathology remains the gold standard for cancer diagnosis and prognosis. With the advent of transcriptome profiling, multi-modal learning combining transcriptomics with histology offers more comprehensive information. However, existing…

Image and Video Processing · Electrical Eng. & Systems 2026-03-03 Yupei Zhang , Xiaofei Wang , Anran Liu , Lequan Yu , Chao Li

We propose a Bayesian latent variable model to estimate covariate-assisted dependence structures across multiple modalities of multivariate data that may be observed asynchronously. This setting commonly arises in longitudinal biomedical…

Methodology · Statistics 2026-05-27 Kun Qian , Hyung G. Park

Gaussian graphical models typically assume a homogeneous structure across all subjects, which is often restrictive in applications. In this article, we propose a weighted pseudo-likelihood approach for graphical modeling which allows…

Methodology · Statistics 2023-03-17 Sutanoy Dasgupta , Peng Zhao , Jacob Helwig , Prasenjit Ghosh , Debdeep Pati , Bani K. Mallick

Medical datasets and especially biobanks, often contain extensive tabular data with rich clinical information in addition to images. In practice, clinicians typically have less data, both in terms of diversity and scale, but still wish to…

Computer Vision and Pattern Recognition · Computer Science 2023-03-31 Paul Hager , Martin J. Menten , Daniel Rueckert

Artificial Intelligence Virtual Cells (AIVCs) aim to learn executable, decision-relevant models of cell state from multimodal, multiscale measurements. Recent studies have introduced single-cell and spatial foundation models, improved…

Artificial Intelligence · Computer Science 2025-12-03 Chengpeng Hu , Calvin Yu-Chian Chen

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve…

We present CardiacGen, a Deep Learning framework for generating synthetic but physiologically plausible cardiac signals like ECG. Based on the physiology of cardiovascular system function, we propose a modular hierarchical generative model…

Machine Learning · Computer Science 2022-11-16 Tushar Agarwal , Emre Ertin

We propose cross-modal attentive connections, a new dynamic and effective technique for multimodal representation learning from wearable data. Our solution can be integrated into any stage of the pipeline, i.e., after any convolutional…

Machine Learning · Computer Science 2022-06-10 Anubhav Bhatti , Behnam Behinaein , Paul Hungler , Ali Etemad

Most current audio-visual emotion recognition models lack the flexibility needed for deployment in practical applications. We envision a multimodal system that works even when only one modality is available and can be implemented…

Machine Learning · Computer Science 2026-01-13 Lucas Goncalves , Seong-Gyun Leem , Wei-Cheng Lin , Berrak Sisman , Carlos Busso

Heterogeneous, mixed type datasets including both continuous and categorical variables are ubiquitous, and enriches data analysis by allowing for more complex relationships and interactions to be modelled. Mixture models offer a flexible…

Methodology · Statistics 2026-03-03 Junyang Wang , James Bennett , Victor Lhoste , Sarah Filippi

Multimodal survival prediction, a crucial yet challenging task, demands the integration of multimodal medical data (\eg Whole Slide Images (WSIs) and Genomic Profiles) to achieve accurate prognostic modeling. Given the inherent…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Huayi Wang , Haochao Ying , Yuyang Xu , Qiyao Zheng , jun wang , Cheng Zhang , Ying Sun , Jian Wu

Deep generative models often perform poorly in real-world applications due to the heterogeneity of natural data sets. Heterogeneity arises from data containing different types of features (categorical, ordinal, continuous, etc.) and…

Machine Learning · Computer Science 2020-06-23 Chao Ma , Sebastian Tschiatschek , José Miguel Hernández-Lobato , Richard Turner , Cheng Zhang

We present a general framework, the coupled compound Poisson factorization (CCPF), to capture the missing-data mechanism in extremely sparse data sets by coupling a hierarchical Poisson factorization with an arbitrary data-generating model.…

Machine Learning · Computer Science 2017-01-10 Mehmet E. Basbug , Barbara E. Engelhardt
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