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Related papers: BrainMorph: A Foundational Keypoint Model for Robu…

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We present KeyMorph, a deep learning-based image registration framework that relies on automatically detecting corresponding keypoints. State-of-the-art deep learning methods for registration often are not robust to large misalignments, are…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Alan Q. Wang , Evan M. Yu , Adrian V. Dalca , Mert R. Sabuncu

Foundation models in artificial intelligence (AI) are transforming medical imaging by enabling general-purpose feature learning from large-scale, unlabeled datasets. In this work, we introduce BrainFound, a self-supervised foundation model…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Moona Mazher , Geoff J. M. Parker , Daniel C. Alexander

The burgeoning field of brain health research increasingly leverages artificial intelligence (AI) to interpret and analyze neurological data. This study introduces a novel approach towards the creation of medical foundation models by…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Joseph Cox , Peng Liu , Skylar E. Stolte , Yunchao Yang , Kang Liu , Kyle B. See , Huiwen Ju , Ruogu Fang

We present Brain Harmony (BrainHarmonix), the first multimodal brain foundation model that unifies structural morphology and functional dynamics into compact 1D token representations. The model was pretrained on two of the largest…

Recent learning-based approaches have made astonishing advances in calibrated medical imaging like computerized tomography (CT), yet they struggle to generalize in uncalibrated modalities -- notably magnetic resonance (MR) imaging, where…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Peirong Liu , Oula Puonti , Xiaoling Hu , Karthik Gopinath , Annabel Sorby-Adams , Daniel C. Alexander , W. Taylor Kimberly , Juan E. Iglesias

In the field of medical image analysis, image registration is a crucial technique. Despite the numerous registration models that have been proposed, existing methods still fall short in terms of accuracy and interpretability. In this paper,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-25 Jiaofen Nan , Gaodeng Fan , Kaifan Zhang , Chen Zhao , Fubao Zhu , Weihua Zhou

Affine image registration is a cornerstone of medical image analysis. While classical algorithms can achieve excellent accuracy, they solve a time-consuming optimization for every image pair. Deep-learning (DL) methods learn a function that…

Image and Video Processing · Electrical Eng. & Systems 2024-07-15 Malte Hoffmann , Andrew Hoopes , Douglas N. Greve , Bruce Fischl , Adrian V. Dalca

This paper presents a novel predictive model, MetaMorph, for metamorphic registration of images with appearance changes (i.e., caused by brain tumors). In contrast to previous learning-based registration methods that have little or no…

Computer Vision and Pattern Recognition · Computer Science 2023-03-10 Jian Wang , Jiarui Xing , Jason Druzgal , William M. Wells , Miaomiao Zhang

The majority of current research in deep learning based image registration addresses inter-patient brain registration with moderate deformation magnitudes. The recent Learn2Reg medical registration benchmark has demonstrated that…

Computer Vision and Pattern Recognition · Computer Science 2022-03-02 Mattias P. Heinrich , Lasse Hansen

Deformable image registration plays a fundamental role in medical image analysis by enabling spatial alignment of anatomical structures across subjects. While recent deep learning-based approaches have significantly improved computational…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Jiaqi Shang , Haojin Wu , Yinyi Lai , Zongyu Li , Chenghao Zhang , Jia Guo

Foundation models are transforming neuroscience but are often prohibitively large, data-hungry, and difficult to deploy. Here, we introduce BrainSymphony, a lightweight and parameter-efficient foundation model with plug-and-play integration…

Quantitative Methods · Quantitative Biology 2026-02-13 Moein Khajehnejad , Forough Habibollahi , Devon Stoliker , Adeel Razi

Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data. Here we show that a single self-supervised representation can…

Machine Learning · Computer Science 2026-05-27 Yizhou Wu , Shansong Wang , Yuheng Li , Mojtaba Safari , Mingzhe Hu , Chih-Wei Chang , Harini Veeraraghavan , Xiaofeng Yang

Medical image challenges have played a transformative role in advancing the field, catalyzing innovation and establishing new performance benchmarks. Image registration, a foundational task in neuroimaging, has similarly advanced through…

We introduce "PatchMorph," an new stochastic deep learning algorithm tailored for unsupervised 3D brain image registration. Unlike other methods, our method uses compact patches of a constant small size to derive solutions that can combine…

Computer Vision and Pattern Recognition · Computer Science 2024-10-28 Henrik Skibbe , Michal Byra , Akiya Watakabe , Tetsuo Yamamori , Marco Reisert

We present brat (brain report alignment transformer), a multi-view representation learning framework for brain magnetic resonance imaging (MRI) trained on MRIs paired with clinical reports. Brain MRIs present unique challenges due to the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Maxime Kayser , Maksim Gridnev , Wanting Wang , Max Bain , Aneesh Rangnekar , Avijit Chatterjee , Aleksandr Petrov , Harini Veeraraghavan , Nathaniel C. Swinburne

Brain foundation models have achieved remarkable advances across a wide range of neuroscience tasks. However, most existing models are limited to a single functional modality, restricting their ability to exploit complementary…

Machine Learning · Computer Science 2026-05-18 Hanning Guo , Hanwen Bi , Farah Abdellatif , Andrei Galbenus , Jon. N. Shah , Abigail Morrison , Jürgen Dammers

Non-rigid cortical registration is an important and challenging task due to the geometric complexity of the human cortex and the high degree of inter-subject variability. A conventional solution is to use a spherical representation of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-28 Jieyu Cheng , Adrian V. Dalca , Bruce Fischl , Lilla Zollei

We present a foundation model for brain MRI that can work with different combinations of imaging sequences. The model uses one encoder with learnable modality embeddings, conditional layer normalization, and a masked autoencoding objective…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Minh Sao Khue Luu , Bair N. Tuchinov

Recent years have seen a surge in research focused on leveraging graph learning techniques to detect neurodegenerative diseases. However, existing graph-based approaches typically lack the ability to localize and extract the specific brain…

Computer Vision and Pattern Recognition · Computer Science 2025-06-16 Nguyen Linh Dan Le , Jing Ren , Ciyuan Peng , Chengyao Xie , Bowen Li , Feng Xia

Analyzing and predicting brain aging is essential for early prognosis and accurate diagnosis of cognitive diseases. The technique of neuroimaging, such as Magnetic Resonance Imaging (MRI), provides a noninvasive means of observing the aging…

Image and Video Processing · Electrical Eng. & Systems 2022-12-06 Jingru Fu , Antonios Tzortzakakis , José Barroso , Eric Westman , Daniel Ferreira , Rodrigo Moreno
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