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Learning high-quality, self-supervised, visual representations is essential to advance the role of computer vision in biomedical microscopy and clinical medicine. Previous work has focused on self-supervised representation learning (SSL)…

Computer Vision and Pattern Recognition · Computer Science 2023-03-06 Cheng Jiang , Xinhai Hou , Akhil Kondepudi , Asadur Chowdury , Christian W. Freudiger , Daniel A. Orringer , Honglak Lee , Todd C. Hollon

Self-supervised learning (SSL) has driven major advances in computational pathology by enabling the learning of rich representations from histopathology data. Yet, tissue analysis alone may fall short in capturing broader molecular…

Machine Learning · Computer Science 2025-12-17 Lucas Robinet , Ahmad Berjaoui , Elizabeth Cohen-Jonathan Moyal

Self-supervised learning (SSL) has emerged as a powerful paradigm for learning representations without labeled data. Most SSL approaches rely on strong, well-established, handcrafted data augmentations to generate diverse views for…

Machine Learning · Computer Science 2026-01-16 Berken Utku Demirel , Christian Holz

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

In digital pathology, whole-slide images (WSIs) are often difficult to handle due to their gigapixel scale, so most approaches train patch encoders via self-supervised learning (SSL) and then aggregate the patch-level embeddings via…

Computer Vision and Pattern Recognition · Computer Science 2025-08-15 Myeongjang Pyeon , Janghyeon Lee , Minsoo Lee , Juseung Yun , Hwanil Choi , Jonghyun Kim , Jiwon Kim , Yi Hu , Jongseong Jang , Soonyoung Lee

Consensus amongst researchers and industry points to a lack of large, representative annotated datasets as the biggest obstacle to progress in the field of surgical data science. Advances in Self-Supervised Learning (SSL) represent a…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Deepak Alapatt , Aditya Murali , Vinkle Srivastav , Pietro Mascagni , AI4SafeChole Consortium , Nicolas Padoy

Sign language representation learning presents unique challenges due to the complex spatio-temporal nature of signs and the scarcity of labeled datasets. Existing methods often rely either on models pre-trained on general visual tasks, that…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Ryan Wong , Necati Cihan Camgoz , Richard Bowden

The landscape of self-supervised learning (SSL) is currently dominated by generative approaches (e.g., MAE) that reconstruct raw low-level data, and predictive approaches (e.g., I-JEPA) that predict high-level abstract embeddings. While…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Scott C. Lowe , Anthony Fuller , Sageev Oore , Evan Shelhamer , Graham W. Taylor

Self-Supervised Learning (SSL) presents an exciting opportunity to unlock the potential of vast, untapped clinical datasets, for various downstream applications that suffer from the scarcity of labeled data. While SSL has revolutionized…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Tassilo Wald , Constantin Ulrich , Stanislav Lukyanenko , Andrei Goncharov , Alberto Paderno , Maximilian Miller , Leander Maerkisch , Paul F. Jäger , Klaus Maier-Hein

Although supervised learning has enabled high performance for image segmentation, it requires a large amount of labeled training data, which can be difficult to obtain in the medical imaging field. Self-supervised learning (SSL) methods…

Single-cell representation learning (SCRL) from gene expression data offers a way to uncover the complex regulatory logic underlying cellular function. Inspired by large language models in natural language modeling, several single-cell…

Machine Learning · Computer Science 2026-05-11 Sachini Weerasekara , Natasha Darras , Sagar Kamarthi , Colles Price , Jacqueline Isaacs

Self-supervised Learning (SSL) including the mainstream contrastive learning has achieved great success in learning visual representations without data annotations. However, most of methods mainly focus on the instance level information…

Computer Vision and Pattern Recognition · Computer Science 2021-07-26 Mingkai Zheng , Shan You , Fei Wang , Chen Qian , Changshui Zhang , Xiaogang Wang , Chang Xu

Self-supervised learning (SSL) has great potential for molecular representation learning given the complexity of molecular graphs, the large amounts of unlabelled data available, the considerable cost of obtaining labels experimentally, and…

Machine Learning · Computer Science 2023-11-30 Yuankai Luo , Lei Shi , Veronika Thost

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

Digital pathology based on whole slide images (WSIs) plays a key role in cancer diagnosis and clinical practice. Due to the high resolution of the WSI and the unavailability of patch-level annotations, WSI classification is usually…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 Litao Yang , Deval Mehta , Sidong Liu , Dwarikanath Mahapatra , Antonio Di Ieva , Zongyuan Ge

Prediction is a fundamental capability of all living organisms, and has been proposed as an objective for learning sensory representations. Recent work demonstrates that in primate visual systems, prediction is facilitated by neural…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Xueyan Niu , Cristina Savin , Eero P. Simoncelli

Self-Supervised Learning (SSL) models rely on a pretext task to learn representations. Because this pretext task differs from the downstream tasks used to evaluate the performance of these models, there is an inherent misalignment or…

Machine Learning · Computer Science 2023-04-12 Florian Bordes , Samuel Lavoie , Randall Balestriero , Nicolas Ballas , Pascal Vincent

Self-supervised learning (SSL) for RGB images has achieved significant success, yet there is still limited research on SSL for infrared images, primarily due to three prominent challenges: 1) the lack of a suitable large-scale infrared…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Tao Zhang , Kun Ding , Jinyong Wen , Yu Xiong , Zeyu Zhang , Shiming Xiang , Chunhong Pan

Self-supervised learning (SSL) is a powerful technique for learning from unlabeled data. By learning to remain invariant to applied data augmentations, methods such as SimCLR and MoCo can reach quality on par with supervised approaches.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Marcin Przewięźlikowski , Mateusz Pyla , Bartosz Zieliński , Bartłomiej Twardowski , Jacek Tabor , Marek Śmieja

Self-supervised pretraining attempts to enhance model performance by obtaining effective features from unlabeled data, and has demonstrated its effectiveness in the field of histopathology images. Despite its success, few works concentrate…

Computer Vision and Pattern Recognition · Computer Science 2023-09-22 Zhiyun Song , Penghui Du , Junpeng Yan , Kailu Li , Jianzhong Shou , Maode Lai , Yubo Fan , Yan Xu
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