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Training a neural network with a large labeled dataset is still a dominant paradigm in computational histopathology. However, obtaining such exhaustive manual annotations is often expensive, laborious, and prone to inter and Intra-observer…

Computer Vision and Pattern Recognition · Computer Science 2021-11-03 Chetan L. Srinidhi , Seung Wook Kim , Fu-Der Chen , Anne L. Martel

Recently, deep neural networks have greatly advanced histopathology image segmentation but usually require abundant annotated data. However, due to the gigapixel scale of whole slide images and pathologists' heavy daily workload, obtaining…

Computer Vision and Pattern Recognition · Computer Science 2023-03-13 Wentao Pan , Jiangpeng Yan , Hanbo Chen , Jiawei Yang , Zhe Xu , Xiu Li , Jianhua Yao

Within medical imaging, manual curation of sufficient well-labeled samples is cost, time and scale-prohibitive. To improve the representativeness of the training dataset, for the first time, we present an approach to utilize large amounts…

Computer Vision and Pattern Recognition · Computer Science 2019-06-03 Fernando Navarro , Sailesh Conjeti , Federico Tombari , Nassir Navab

In this work, we propose a novel straightforward method for medical volume and sequence segmentation with limited annotations. To avert laborious annotating, the recent success of self-supervised learning(SSL) motivates the pre-training on…

Computer Vision and Pattern Recognition · Computer Science 2023-10-04 Zejian Chen , Wei Zhuo , Tianfu Wang , Wufeng Xue , Dong Ni

Predicting the response of a patient to a cancer treatment is of high interest. Nonetheless, this task is still challenging from a medical point of view due to the complexity of the interaction between the patient organism and the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-09 Bilel Guetarni , Feryal Windal , Halim Benhabiles , Mahfoud Chaibi , Romain Dubois , Emmanuelle Leteurtre , Dominique Collard

Automated medical diagnosis through image-based neural networks has increased in popularity and matured over years. Nevertheless, it is confined by the scarcity of medical images and the expensive labor annotation costs. Self-Supervised…

Computer Vision and Pattern Recognition · Computer Science 2024-04-17 Luffina C. Huang , Darren J. Chiu , Manish Mehta

Multimodal survival methods combining gigapixel histology whole-slide images (WSIs) and transcriptomic profiles are particularly promising for patient prognostication and stratification. Current approaches involve tokenizing the WSIs into…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Andrew H. Song , Richard J. Chen , Guillaume Jaume , Anurag J. Vaidya , Alexander S. Baras , Faisal Mahmood

Decoding fine-grained movement from non-invasive surface Electromyography (sEMG) is a challenge for prosthetic control due to signal non-stationarity and low signal-to-noise ratios. Generic self-supervised learning (SSL) frameworks often…

Human-Computer Interaction · Computer Science 2025-12-30 Zihan Weng , Chanlin Yi , Pouya Bashivan , Jing Lu , Fali Li , Dezhong Yao , Jingming Hou , Yangsong Zhang , Peng Xu

Convolutional neural networks can be trained to perform histology slide classification using weak annotations with multiple instance learning (MIL). However, given the paucity of labeled histology data, direct application of MIL can easily…

Computer Vision and Pattern Recognition · Computer Science 2019-11-05 Ming Y. Lu , Richard J. Chen , Jingwen Wang , Debora Dillon , Faisal Mahmood

Self-supervised learning (SSL) has led to important breakthroughs in computer vision by allowing learning from large amounts of unlabeled data. As such, it might have a pivotal role to play in biomedicine where annotating data requires a…

Computer Vision and Pattern Recognition · Computer Science 2024-03-14 Roy Hirsch , Mathilde Caron , Regev Cohen , Amir Livne , Ron Shapiro , Tomer Golany , Roman Goldenberg , Daniel Freedman , Ehud Rivlin

Self-supervised pretraining has become the mainstream approach for learning MRI representations from unlabeled scans. However, most existing objectives still treat each scan primarily as static aggregations of slices, patches or volumes. We…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Yu Wang , Qingchao Chen

Digital pathological analysis is run as the main examination used for cancer diagnosis. Recently, deep learning-driven feature extraction from pathology images is able to detect genetic variations and tumor environment, but few studies…

Computer Vision and Pattern Recognition · Computer Science 2022-04-28 Haojie Huang , Gongming Zhou , Xuejun Liu , Lei Deng , Chen Wu , Dachuan Zhang , Hui Liu

Self-supervised representation learning (SSL) on biomedical networks provides new opportunities for drug discovery. However, how to effectively combine multiple SSL models is still challenging and has been rarely explored. Therefore, we…

Machine Learning · Computer Science 2022-12-20 Xiaoqi Wang , Yingjie Cheng , Yaning Yang , Yue Yu , Fei Li , Shaoliang Peng

In histopathology, intelligent diagnosis of Whole Slide Images (WSIs) is essential for automating and objectifying diagnoses, reducing the workload of pathologists. However, diagnostic models often face the challenge of forgetting…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Weixi Zheng , Aoling Huang , Jingping Yuan , Haoyu Zhao , Zhou Zhao , Yongchao Xu , Thierry Géraud

Large language models (LLMs) have shown strong ability in generating rich representations across domains such as natural language processing and generation, computer vision, and multimodal learning. However, their application in biomedical…

Genomics · Quantitative Biology 2025-09-30 Luxuan Zhang , Douglas Jiang , Qinglong Wang , Haoqi Sun , Feng Tian

Subtle hand differences make sign language recognition challenging, yet many existing methods rely on encoders pretrained on generic action datasets that poorly capture such fine-grained cues. We propose a self-supervised pretraining method…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Kunyuan Xie , Zhixi Cai , Kalin Stefanov

Computational pathology models that use digitized histopathology whole-slide images have the potential to become a cost-effective and scalable alternative to molecular assays for the prediction of genomic biomarkers, a key task in precision…

Quantitative Methods · Quantitative Biology 2026-03-03 Ekaterina Redekop , Eric Zimmermann , Ava P Amini , Alex X Lu , Neil Tenenholtz , James Brian Hall , Lorin Crawford , Kristen A Severson

Self-supervised learning (SSL) as an effective paradigm of representation learning has achieved tremendous success on various curated datasets in diverse scenarios. Nevertheless, when facing the long-tailed distribution in real-world…

Machine Learning · Computer Science 2023-10-27 Zhihan Zhou , Jiangchao Yao , Feng Hong , Ya Zhang , Bo Han , Yanfeng Wang

Self-supervised learning (SSL) has emerged as a powerful paradigm for medical image representation learning, particularly in settings with limited labeled data. However, existing SSL methods often rely on complex architectures,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Azad Singh , Deepak Mishra

Self-supervised learning (SSL) achieves great success in speech recognition, while limited exploration has been attempted for other speech processing tasks. As speech signal contains multi-faceted information including speaker identity,…

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