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We investigate Learning from Label Proportions (LLP), a partial information setting where examples in a training set are grouped into bags, and only aggregate label values in each bag are available. Despite the partial observability, the…

Machine Learning · Computer Science 2025-06-02 Robert Busa-Fekete , Travis Dick , Claudio Gentile , Haim Kaplan , Tomer Koren , Uri Stemmer

Learning from Label Proportions (LLP) is a weakly supervised learning method that aims to perform instance classification from training data consisting of pairs of bags containing multiple instances and the class label proportions within…

Machine Learning · Computer Science 2023-02-22 Ryoma Kobayashi , Yusuke Mukuta , Tatsuya Harada

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Delineation of cancerous regions in gigapixel whole slide images (WSIs) is a crucial diagnostic procedure in digital pathology. This process is time-consuming because of the large search space in the gigapixel WSIs, causing chances of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Hsien-Tzu Cheng , Chun-Fu Yeh , Po-Chen Kuo , Andy Wei , Keng-Chi Liu , Mong-Chi Ko , Kuan-Hua Chao , Yu-Ching Peng , Tyng-Luh Liu

This paper addresses the problem of liver cancer segmentation in Whole Slide Image (WSI). We propose a multi-scale image processing method based on automatic end-to-end deep neural network algorithm for segmentation of cancer area. A…

Image and Video Processing · Electrical Eng. & Systems 2020-07-29 Yanbo Feng , Adel Hafiane , Hélène Laurent

Learning from label proportions (LLP) is a kind of weakly supervised learning that trains an instance-level classifier from label proportions of bags, which consist of sets of instances without using instance labels. A challenge in LLP…

Machine Learning · Computer Science 2024-08-27 Shunsuke Kubo , Shinnosuke Matsuo , Daiki Suehiro , Kazuhiro Terada , Hiroaki Ito , Akihiko Yoshizawa , Ryoma Bise

In the problem of learning with label proportions, which we call LLP learning, the training data is unlabeled, and only the proportions of examples receiving each label are given. The goal is to learn a hypothesis that predicts the…

Machine Learning · Computer Science 2020-04-08 Benjamin Fish , Lev Reyzin

Classification of gigapixel Whole Slide Images (WSIs) is an important prediction task in the emerging area of computational pathology. There has been a surge of research in deep learning models for WSI classification with clinical…

Computer Vision and Pattern Recognition · Computer Science 2023-05-04 Sajid Javed , Arif Mahmood , Talha Qaiser , Naoufel Werghi , Nasir Rajpoot

In learning from label proportions (LLP), the instances are grouped into bags, and the task is to learn an instance classifier given relative class proportions in training bags. LLP is useful when obtaining individual instance labels is…

Machine Learning · Computer Science 2022-11-01 Denis Baručić , Jan Kybic

In computational pathology, multiple instance learning (MIL) is widely used to circumvent the computational impasse in giga-pixel whole slide image (WSI) analysis. It usually consists of two stages: patch-level feature extraction and…

Image and Video Processing · Electrical Eng. & Systems 2023-09-21 Beidi Zhao , Wenlong Deng , Zi Han , Li , Chen Zhou , Zuhua Gao , Gang Wang , Xiaoxiao Li

Learning from label proportions (LLP) is a weakly supervised classification problem where data points are grouped into bags, and the label proportions within each bag are observed instead of the instance-level labels. The task is to learn a…

Machine Learning · Computer Science 2023-09-26 Jianxin Zhang , Yutong Wang , Clayton Scott

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Learning from Label Proportions (LLP) is a weakly supervised problem in which the training data comprise bags, that is, groups of instances, each annotated only with bag-level class label proportions, and the objective is to learn a…

Machine Learning · Computer Science 2026-03-24 Tianhao Ma , Ximing Li , Changchun Li , Renchu Guan

Learning from label proportions (LLP) aims at learning an instance-level classifier with label proportions in grouped training data. Existing deep learning based LLP methods utilize end-to-end pipelines to obtain the proportional loss with…

Machine Learning · Computer Science 2021-05-25 Jiabin Liu , Bo Wang , Xin Shen , Zhiquan Qi , Yingjie Tian

Tumor segmentation stands as a pivotal task in cancer diagnosis. Given the immense dimensions of whole slide images (WSI) in histology, deep learning approaches for WSI classification mainly operate at patch-wise or superpixel-wise level.…

Computer Vision and Pattern Recognition · Computer Science 2024-02-22 Huaqian Wu , Clara Brémond-Martin , Kévin Bouaou , Cédric Clouchoux

In pathology, the spatial distribution and proportions of tissue types are key indicators of disease progression, and are more readily available than fine-grained annotations. However, these assessments are rarely mapped to pixel-wise…

Image and Video Processing · Electrical Eng. & Systems 2026-04-28 Yangping Li , Thomas Pinetz , Michael Hölzel , Marieta Toma , Alexander Effland

Learning from label proportions (LLP) is a generalization of supervised learning in which the training data is available as sets or bags of feature-vectors (instances) along with the average instance-label of each bag. The goal is to train…

Machine Learning · Computer Science 2023-10-17 Anand Brahmbhatt , Rishi Saket , Aravindan Raghuveer

We address the challenging problem of whole slide image (WSI) classification. WSIs have very high resolutions and usually lack localized annotations. WSI classification can be cast as a multiple instance learning (MIL) problem when only…

Computer Vision and Pattern Recognition · Computer Science 2021-04-05 Bin Li , Yin Li , Kevin W. Eliceiri

The PD-L1 rate, the number of PD-L1 positive tumor cells over the total number of all tumor cells, is an important metric for immunotherapy. This metric is recorded as diagnostic information with pathological images. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2024-05-09 Takumi Okuo , Kazuya Nishimura , Hiroaki Ito , Kazuhiro Terada , Akihiko Yoshizawa , Ryoma Bise

Whole Slide Imaging (WSI) has become an important topic during the last decade. Even though significant progress in both medical image processing and computational resources has been achieved, there are still problems in WSI that need to be…

Image and Video Processing · Electrical Eng. & Systems 2019-03-19 Wafa Chenni , Habib Herbi , Morteza Babaie , H. R. Tizhoosh
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