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Molecule-surface interaction is key to many physical and chemical processes at interfaces. Here, we show that the dynamics of single molecules on a surface under ultrahigh vacuum can be resolved using fluorescence imaging. By adapting…

Chemical Physics · Physics 2021-10-19 Tianyu Fang , Florian Elsen , Nick Vogeley , Daqing Wang

A reliable and user-friendly characterisation of nano-objects in a target material is presented here in the form of a software data analysis package for interpreting small-angle X-ray scattering (SAXS) patterns. When provided with data on…

Data Analysis, Statistics and Probability · Physics 2014-12-08 Ingo Breßler , Brian R. Pauw , Andreas Thünemann

Simplified Molecular Input Line Entry System (SMILES) is a single line text representation of a unique molecule. One molecule can however have multiple SMILES strings, which is a reason that canonical SMILES have been defined, which ensures…

Machine Learning · Computer Science 2017-05-18 Esben Jannik Bjerrum

Spectrum sensing and analysis is crucial for a variety of reasons, including regulatory compliance, interference detection and mitigation, and spectrum resource planning and optimization. Effective, real-time spectrum analysis remains a…

Signal Processing · Electrical Eng. & Systems 2026-01-21 Rahil Gandotra , Ruoyu Sun , Mark Poletti , Jiayu Mao , Hao Guo

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

We report our design, development, installation and troubleshooting of an open source Gnome X Scanning Microscopy (GXSM) software package for controlling and processing of modern Scanning Probe Microscopy (SPM) system as a development tool…

Instrumentation and Detectors · Physics 2014-10-13 S. K. Suresh Babu , J. S. Devrenjith Singh , D. Jackuline Moni , D. Devaprakasam

Super-resolution optical fluctuation imaging (SOFI) provides a resolution beyond the diffraction limit by analysing stochastic fluorescence fluctuations with higher-order statistics. Using nth order spatio-temporal cross-cumulants the…

Two-dimensional electronic spectroscopy provides information on coupling and energy transfer between excited states on ultrafast timescales. Only recently, incoherent fluorescence detection has made it possible to combine this method with…

Optics · Physics 2025-05-14 Sanchayeeta Jana , Simon Durst , Lucas Ludwig , Markus Lippitz

Optical spectroscopy is an important and widely used technique, for instance, to characterize new materials and to identify unknown compounds. Spectra are typically reported as a function of the wavelength of light, yet the information…

Optics · Physics 2026-05-06 Erik F. Woering , Richard Hildner

We present Style Matching Score (SMS), a novel optimization method for image stylization with diffusion models. Balancing effective style transfer with content preservation is a long-standing challenge. Unlike existing efforts, our method…

Computer Vision and Pattern Recognition · Computer Science 2025-07-23 Yuxin Jiang , Liming Jiang , Shuai Yang , Jia-Wei Liu , Ivor Tsang , Mike Zheng Shou

Molecular dynamics simulations have a prominent role in biophysics and drug discovery due to the atomistic information they provide on the structure, energetics and dynamics of biomolecules. Specialized software packages are required to…

Computational Physics · Physics 2013-10-08 Toni Giorgino

We review methods of data analysis for biophysical data with a special emphasis on single molecule applications. Our review is intended for anyone, from student to established researcher. For someone just getting started, we focus on…

Biological Physics · Physics 2016-11-24 Meysam Tavakoli , J. Nicholas Taylor , Chun-Biu Li , Tamiki Komatsuzaki , Steve Pressé

In this paper we describe the main features of the software package named FITSH, intended to provide a standalone environment for analysis of data acquired by imaging astronomical detectors. The package provides utilities both for the full…

Instrumentation and Methods for Astrophysics · Physics 2015-06-03 András Pál

During the last decade, a large number of different numerical methods have been proposed to tackle the automatic identification and quantification in {\gamma}-ray spectrometry. However, the lack of common benchmarks, including datasets,…

Machine Learning · Computer Science 2025-08-13 Dinh Triem Phan , Jérôme Bobin , Cheick Thiam , Christophe Bobin

Spectroscopy is an indispensable tool in understanding the structures and dynamics of molecular systems. However computational modelling of spectroscopy is challenging due to the exponential scaling of computational complexity with system…

Quantum Physics · Physics 2021-06-22 Chee-Kong Lee , Chang-Yu Hsieh , Shengyu Zhang , Liang Shi

We present a dual color laser scanning endomicroscope capable of fluorescence lifetime endomicroscopy at one frame per second (FPS). The scanning system uses a coherent imaging fiber with 30,000 cores. High-speed lifetime imaging is…

Forthcoming instruments designed for high-cadence large-area surveys, such as the Dark Energy Survey and Large Synoptic Survey Telescope, will generate several GB of data products every few minutes during survey operations. Since such…

Instrumentation and Methods for Astrophysics · Physics 2012-08-01 K. Kuehn , R. Hupe

We introduce HAMscope, a compact, snapshot hyperspectral autofluorescence miniscope that enables real-time, label-free molecular imaging in a wide range of biological systems. By integrating a thin polymer diffuser into a widefield…

The advent of single molecule optics has had a profound impact in fields ranging from biophysics to material science, photophysics, and quantum optics. However, all existing room-temperature single molecule methods have been based on…

Mesoscale and Nanoscale Physics · Physics 2010-07-22 Michele Celebrano , Philipp Kukura , Alois Renn , Vahid Sandoghdar

We propose an efficient algorithm for reconstructing one-dimensional wide-band line spectra from their Fourier data in a bounded interval $[-\Omega,\Omega]$. While traditional subspace methods such as MUSIC achieve super-resolution for…

Signal Processing · Electrical Eng. & Systems 2023-10-30 Zetao Fei , Hai Zhang