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We study computational and statistical consequences of problem geometry in stochastic and online optimization. By focusing on constraint set and gradient geometry, we characterize the problem families for which stochastic- and…

Optimization and Control · Mathematics 2025-07-17 Chen Cheng , Daniel Levy , John C. Duchi

Electron cryomicroscopy (cryo-EM) is an imaging technique widely used in structural biology to determine the three-dimensional structure of biological molecules from noisy two-dimensional projections with unknown orientations. As the…

Numerical Analysis · Mathematics 2025-06-26 Bogdan Toader , Marcus A. Brubaker , Roy R. Lederman

For the two-layer shallow water equations, a high-order compact gas-kinetic scheme (GKS) on triangular mesh is proposed. The two-layer shallow water equations have complex source terms in comparison with the single layer equations. The main…

Numerical Analysis · Mathematics 2023-06-08 Fengxiang Zhao , Jianping Gan , Kun Xu

The Kernel Polynomial Method (KPM) is one of the fast diagonalization methods used for simulations of quantum systems in research fields of condensed matter physics and chemistry. The algorithm has a difficulty to be parallelized on a…

Computational Physics · Physics 2011-05-30 Shixun Zhang , Shinichi Yamagiwa , Masahiko Okumura , Seiji Yunoki

Optimization with constraints is a typical problem in quantum physics and quantum information science that becomes especially challenging for high-dimensional systems and complex architectures like tensor networks. Here we use ideas of…

Quantum Physics · Physics 2021-11-18 Ilia A. Luchnikov , Mikhail E. Krechetov , Sergey N. Filippov

This paper presents a method to generate valid high order meshes with optimized geometrical accuracy. The high order meshing procedure starts with a linear mesh, that is subsequently curved without taking care of the validity of the high…

Computational Physics · Physics 2016-03-23 Thomas Toulorge , Jonathan Lambrechts , Jean-François Remacle

Molecular discovery within the vast chemical space remains a significant challenge due to the immense number of possible molecules and limited scalability of conventional screening methods. To approach chemical space exploration more…

Chemical Physics · Physics 2025-07-16 Luis J. Walter , Tristan Bereau

Owing to the computational complexity of electronic structure algorithms running on classical digital computers, the range of molecular systems amenable to simulation remains tightly circumscribed even after many decades of work. Quantum…

Quantum Physics · Physics 2022-05-18 Alexis Ralli , Michael I. Williams , Peter V. Coveney

Gradient-free optimizers allow for tackling problems regardless of the smoothness or differentiability of their objective function, but they require many more iterations to converge when compared to gradient-based algorithms. This has made…

Machine Learning · Computer Science 2024-09-24 Gawel Kus , Miguel A. Bessa

Modeling electronic systems is an important application for quantum computers. In the context of materials science, an important open problem is the computational description of chemical reactions on surfaces. In this work, we outline a…

Numerous molecular systems, including solutions, proteins, and composite materials, can be modeled using mixed-resolution representations, of which the quantum mechanics/molecular mechanics (QM/MM) approach has become the most widely used.…

Chemical Physics · Physics 2018-01-17 Anton V. Sinitskiy , Gregory A. Voth

Local optimization presents a promising approach to expensive, high-dimensional black-box optimization by sidestepping the need to globally explore the search space. For objective functions whose gradient cannot be evaluated directly,…

Machine Learning · Computer Science 2023-01-18 Quan Nguyen , Kaiwen Wu , Jacob R. Gardner , Roman Garnett

Manifold optimization is ubiquitous in computational and applied mathematics, statistics, engineering, machine learning, physics, chemistry and etc. One of the main challenges usually is the non-convexity of the manifold constraints. By…

Optimization and Control · Mathematics 2019-06-14 Jiang Hu , Xin Liu , Zaiwen Wen , Yaxiang Yuan

Executing quantum circuits on currently available quantum computers requires compiling them to a representation that conforms to all restrictions imposed by the targeted architecture. Due to the limited connectivity of the devices' physical…

Quantum Physics · Physics 2023-01-11 Lukas Burgholzer , Sarah Schneider , Robert Wille

Bayesian inverse problems often involve sampling posterior distributions on infinite-dimensional function spaces. Traditional Markov chain Monte Carlo (MCMC) algorithms are characterized by deteriorating mixing times upon mesh-refinement,…

Computation · Statistics 2017-03-08 Alexandros Beskos , Mark Girolami , Shiwei Lan , Patrick E. Farrell , Andrew M. Stuart

Multitime quantum correlation functions are central objects in physical science, offering a direct link between experimental observables and the dynamics of an underlying model. While experiments such as 2D spectroscopy and quantum control…

Chemical Physics · Physics 2024-07-10 Thomas Sayer , Andrés Montoya-Castillo

Optical molecular tomographic imaging is to reconstruct the concentration distribution of photon-molecular probes in a small animal from measured photon fluence rates. The localization and quantification of molecular probes is related to…

Biological Physics · Physics 2017-07-18 Wenxiang Cong , Xavier Intes , Ge Wang

We explore the use of the Gauss-Newton method for optimization in shape learning, including implicit neural surfaces and geometry-informed neural networks. The method addresses key challenges in shape learning, such as the ill-conditioning…

Machine Learning · Computer Science 2026-02-16 James King , Arturs Berzins , Siddhartha Mishra , Marius Zeinhofer

Bayesian optimization is a data-efficient technique which can be used for control parameter tuning, parametric policy adaptation, and structure design in robotics. Many of these problems require optimization of functions defined on…

The Euclidean distance geometry problem arises in a wide variety of applications, from determining molecular conformations in computational chemistry to localization in sensor networks. When the distance information is incomplete, the…

Information Theory · Computer Science 2018-10-30 Abiy Tasissa , Rongjie Lai