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With the advent of high-performance computing techniques, the data for analysis has grown significantly. Here, graphic processing unit (GPU) based program kernels are discussed to exploit parallelism in the analysis codes specific to…

Computational Physics · Physics 2018-11-07 Gourav Shrivastav , Manish Agarwal

Variational Quantum Algorithms (VQAs) are a promising approach for practical applications like chemistry and materials science on near-term quantum computers as they typically reduce quantum resource requirements. However, in order to…

Quantum Physics · Physics 2022-06-07 Andi Gu , Angus Lowe , Pavel A. Dub , Patrick J. Coles , Andrew Arrasmith

We present a time-parallelization method that enables to accelerate the computation of quantum optimal control algorithms. We show that this approach is approximately fully efficient when based on a gradient method as optimization solver:…

Optimization and Control · Mathematics 2016-05-04 Mohamed-Kamel Riahi , Julien Salomon , S. J. Glaser , D Sugny

Molecule optimization is a fundamental task for accelerating drug discovery, with the goal of generating new valid molecules that maximize multiple drug properties while maintaining similarity to the input molecule. Existing generative…

Machine Learning · Computer Science 2024-07-02 Tianfan Fu , Cao Xiao , Xinhao Li , Lucas M. Glass , Jimeng Sun

Recently, 3D Gaussian Splatting has emerged as a prominent research direction owing to its ultrarapid training speed and high-fidelity rendering capabilities. However, the unstructured and irregular nature of Gaussian point clouds poses…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Xiao Ren , Yu Liu , Ning An , Jian Cheng , Xin Qiao , He Kong

Recent developments for mathematical modeling and numerical simulation of biomolecular systems raise new demands for qualified, stable, and efficient surface meshing, especially in implicit-solvent modeling. In our former work, we have…

Numerical Analysis · Mathematics 2016-11-11 Tiantian Liu , Minxin Chen , Benzhuo Lu

The implementation and practicality of quantum algorithms highly hinge on the quality of operations within a quantum processor. Therefore, including realistic error models in quantum computing simulation platforms is crucial for testing…

Quantum Physics · Physics 2021-04-12 Ahmed Abid Moueddene , Nader Khammassi , Koen Bertels , Carmen G. Almudever

Quantum-circuit optimization is essential for any practical realization of quantum computation, in order to beat decoherence. We present a scheme for implementing the final stage in the compilation of quantum circuits, i.e., for finding the…

Quantum Physics · Physics 2007-05-23 Juha J. Vartiainen , Antti O. Niskanen , Mikio Nakahara , Martti M. Salomaa

A milestone in the field of quantum computing will be solving problems in quantum chemistry and materials faster than state-of-the-art classical methods. The current understanding is that achieving quantum advantage in this area will…

Quantum Physics · Physics 2023-11-08 Guoming Wang , Daniel Stilck França , Ruizhe Zhang , Shuchen Zhu , Peter D. Johnson

In this work, we adopt the Gradient Projection Method (GPM) to problems of quantum control. For general $N$-level closed and open quantum systems, we derive the corresponding adjoint systems and gradients of the objective functionals, and…

Quantum Physics · Physics 2025-09-03 Oleg Morzhin , Alexander Pechen

Structure-Based molecule optimization (SBMO) aims to optimize molecules with both continuous coordinates and discrete types against protein targets. A promising direction is to exert gradient guidance on generative models given its…

Biomolecules · Quantitative Biology 2025-06-06 Keyue Qiu , Yuxuan Song , Jie Yu , Hongbo Ma , Ziyao Cao , Zhilong Zhang , Yushuai Wu , Mingyue Zheng , Hao Zhou , Wei-Ying Ma

Topology optimization is an essential tool in computational engineering, for example, to improve the design and efficiency of flow channels. At the same time, Ising machines, including digital or quantum annealers, have been used as…

Computational Engineering, Finance, and Science · Computer Science 2024-11-14 Yudai Suzuki , Shiori Aoki , Fabian Key , Katsuhiro Endo , Yoshiki Matsuda , Shu Tanaka , Marek Behr , Mayu Muramatsu

Molecular optimization, which aims to discover improved molecules from a vast chemical search space, is a critical step in chemical development. Various artificial intelligence technologies have demonstrated high effectiveness and…

Chemical Physics · Physics 2024-11-26 Xin Xia , Yajie Zhang , Xiangxiang Zeng , Xingyi Zhang , Chunhou Zheng , Yansen Su

Optimizing the mRNA codon has an essential impact on gene expression for a specific target protein. It is an NP-hard problem; thus, exact solutions to such optimization problems become computationally intractable for realistic problem sizes…

Quantum Physics · Physics 2024-05-13 Hongfeng Zhang , Aritra Sarkar , Koen Bertels

Over the last two decades, the field of geometric curve evolutions has attracted significant attention from scientific computing. One of the most popular numerical methods for solving geometric flows is the so-called BGN scheme, which was…

Numerical Analysis · Mathematics 2024-06-21 Wei Jiang , Chunmei Su , Ganghui Zhang

We consider the problem of deciding whether a given state preparation, i.e., a source of quantum states, is accurate, namely produces states close to a target one within a prescribed threshold. We show that, when multiple measurements need…

Quantum Physics · Physics 2024-01-22 Weichao Liang , Francesco Ticozzi , Giuseppe Vallone

We present a new adaptive resolution technique for efficient particle-based multiscale molecular dynamics (MD) simulations. The presented approach is tailor-made for molecular systems where atomistic resolution is required only in spatially…

Soft Condensed Matter · Physics 2007-05-23 Matej Praprotnik , Luigi Delle Site , Kurt Kremer

Satellite mission planning for Earth observation satellites is a combinatorial optimization problem that consists of selecting the optimal subset of imaging requests, subject to constraints, to be fulfilled during an orbit pass of a…

The calculation of minimum energy paths for transitions such as atomic and/or spin re-arrangements is an important task in many contexts and can often be used to determine the mechanism and rate of transitions. An important challenge is to…

Chemical Physics · Physics 2017-03-31 Olli-Pekka Koistinen , Emile Maras , Aki Vehtari , Hannes Jónsson

Quantum circuit mapping is a critical process in quantum computing that involves adapting logical quantum circuits to adhere to hardware constraints, thereby generating physically executable quantum circuits. Current quantum circuit mapping…

Quantum Physics · Physics 2025-07-08 Wenjie Sun , Xiaoyu Li , Lianhui Yu , Zhigang Wang , Geng Chen , Guowu Yang
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