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The dose delivered to the planning target volume by proton beams is highly conformal, sparing organs at risk and normal tissues. New treatment planning systems adapted to spot scanning techniques have been recently proposed to…

Medical Physics · Physics 2022-05-18 François Smekens , Nicolas Freud , Bruno Sixou , Guillaume Beslon , Jean M Létang

The precise theoretical determination of the geometrical parameters of molecules at the minima of their potential energy surface and of the corresponding vibrational properties are of fundamental importance for the interpretation of…

Strongly Correlated Electrons · Physics 2013-06-19 Andrea Zen , Delyan Zhelyazov , Leonardo Guidoni

We present a hardware-efficient optimization scheme for quantum chemistry calculations, utilizing the Sampled Quantum Diagonalization (SQD) method. Our algorithm, optimized SQD (SQDOpt), combines the classical Davidson method technique with…

Quantum Physics · Physics 2025-03-05 Nora Bauer , Kübra Yeter-Aydeniz , George Siopsis

We show that optimal control of the electron dynamics is able to prepare molecular ground states, within chemical accuracy, with evolution times approaching the bounds imposed by quantum mechanics. We propose a specific parameterization of…

Quantum Physics · Physics 2024-02-20 Davide Castaldo , Marta Rosa , Stefano Corni

Knowing a biomolecule's structure is inherently linked to and a prerequisite for any detailed understanding of its function. Significant effort has gone into developing technologies for structural characterization. These technologies do not…

Data Structures and Algorithms · Computer Science 2017-06-22 Michael Wegner , Oskar Taubert , Alexander Schug , Henning Meyerhenke

As the use of machine learning (ML) permeates into diverse application domains, there is an urgent need to support a declarative framework for ML. Ideally, a user will specify an ML task in a high-level and easy-to-use language and the…

An efficient error reconciliation scheme is important for post-processing of quantum key distribution (QKD). Recently, a multi-matrix low-density parity-check codes based reconciliation algorithm which can provide remarkable perspectives…

Quantum Physics · Physics 2020-01-23 Yu Guo , Chaohui Gao , Dong Jiang , Lijun Chen

Quantum Monte Carlo is an efficient technique for finding the ground-state energy and related properties of small molecules. A major challenge remains in accurate determination of a molecule's geometry, i.e. the optimal location of its…

Computational Physics · Physics 2017-04-12 Jan Vrbik

Modelling and understanding properties of materials from first principles require knowledge of the underlying atomistic structure. This entails knowing the individual identity and position of all involved atoms. Obtaining such information…

Chemical Physics · Physics 2023-07-06 Mads-Peter Verner Christiansen , Nikolaj Rønne , Bjørk Hammer

Efficient and reliable identification and optimization of transition state structures is a longstanding challenge in computational chemistry. Popular chain-of-states methods require hundreds if not thousands of ab initio calculations to…

Chemical Physics · Physics 2025-11-27 Diptarka Hait , Jan D. Estrada Pabón , Martin Stöhr , Todd J. Martínez

Gradient methods are widely used in optimization problems. In practice, while the smoothness parameter can be estimated utilizing techniques such as backtracking, estimating the strong convexity parameter remains a challenge; moreover, even…

Optimization and Control · Mathematics 2026-02-17 Xiaozhe Hu , Sara Pollock , Zhongqin Xue , Yunrong Zhu

Recent advances in neural rendering have introduced numerous 3D scene representations. Although standard computer vision metrics evaluate the visual quality of generated images, they often overlook the fidelity of surface geometry. This…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Mikolaj Zielinski , Eryk Vykysaly , Bartlomiej Biesiada , Jan Baturo , Mateusz Capala , Dominik Belter

Optimizing the structure of molecules to achieve desired properties is a central bottleneck across the chemical sciences, particularly in the pharmaceutical industry where it underlies the discovery of new drugs. Since molecular property…

Artificial Intelligence · Computer Science 2026-02-19 Fabian P. Krüger , Andrea Hunklinger , Adrian Wolny , Tim J. Adler , Igor Tetko , Santiago David Villalba

In early-stage architectural design, optimization algorithms are essential for efficiently exploring large and complex design spaces under tight computational constraints. While prior research has benchmarked various optimization methods,…

Neural and Evolutionary Computing · Computer Science 2025-04-14 Farnaz Nazari , Wei Yan

We present a gradient-based optimal-control technique for open quantum systems that utilizes quantum trajectories to simulate the quantum dynamics during optimization. Using trajectories allows for optimizing open systems with less…

Quantum Physics · Physics 2019-06-03 Mohamed Abdelhafez , David I. Schuster , Jens Koch

Optimizing parameterized quantum circuits is a key routine in using near-term quantum devices. However, the existing algorithms for such optimization require an excessive number of quantum-measurement shots for estimating expectation values…

Quantum Physics · Physics 2022-08-04 Shiro Tamiya , Hayata Yamasaki

Gradient Descent (GD) is a ubiquitous algorithm for finding the optimal solution to an optimization problem. For reduced computational complexity, the optimal solution $\mathrm{x^*}$ of the optimization problem must be attained in a minimum…

Optimization and Control · Mathematics 2023-06-01 Revati Gunjal , Sushama Wagh , Syed Shadab Nayyer , Alex Stankovic , Navdeep M. Singh

Computational meshes arising from shape optimization routines commonly suffer from decrease of mesh quality or even destruction of the mesh. In this work, we provide an approach to regularize general shape optimization problems to increase…

Optimization and Control · Mathematics 2021-03-30 Daniel Luft , Volker Schulz

Due to the wide range of timescales that are present in macromolecular systems, hierarchical multiscale strategies are necessary for their computational study. Coarse-graining (CG) allows to establish a link between different system…

We explore the performance of a statistical learning technique based on Gaussian Process (GP) regression as an efficient non-parametric method for constructing multi-dimensional potential energy surfaces (PES) for polyatomic molecules.…

Chemical Physics · Physics 2016-11-23 Jie Cui , Roman V. Krems