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Related papers: Clinical Trials Protocol Authoring using LLMs

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Clinical trials are pivotal in the drug discovery process to determine the safety and efficacy of a drug candidate. The high failure rates of these trials are attributed to deficiencies in clinical model development and protocol design.…

Generative Pre-trained Transformer 4 (GPT-4) is the fourth-generation language model in the GPT series, developed by OpenAI, which promises significant advancements in the field of natural language processing (NLP). In this research…

Computation and Language · Computer Science 2023-05-08 Jawid Ahmad Baktash , Mursal Dawodi

The performance of modern AI systems is fundamentally constrained by the quality of their underlying kernels, which translate high-level algorithmic semantics into low-level hardware operations. Achieving near-optimal kernels requires…

Machine learning (ML) holds great promise for clinical applications but is often hindered by limited access to high-quality data due to privacy concerns, high costs, and long timelines associated with clinical trials. While large language…

Computation and Language · Computer Science 2026-03-27 Zerui Xu , Fang Wu , Yingzhou Lu , Yuanyuan Zhang , Yue Zhao

Artificial Intelligence (AI) is making a major impact on healthcare, particularly through its application in natural language processing (NLP) and predictive analytics. The healthcare sector has increasingly adopted AI for tasks such as…

Databases · Computer Science 2025-06-02 Karan Hanswadkar , Anika Kanchi , Shivani Tripathi , Shi Qiao , Rony Chatterjee , Alekh Jindal

Researchers often rely on humans to code (label, annotate, etc.) large sets of texts. This kind of human coding forms an important part of social science research, yet the coding process is both resource intensive and highly variable from…

Artificial Intelligence · Computer Science 2023-06-06 Christopher Michael Rytting , Taylor Sorensen , Lisa Argyle , Ethan Busby , Nancy Fulda , Joshua Gubler , David Wingate

Large Language Models (LLMs) have emerged as transformative tools in the healthcare sector, demonstrating remarkable capabilities in natural language understanding and generation. However, their proficiency in numerical reasoning,…

Artificial Intelligence · Computer Science 2025-01-27 Arjun R. Malghan

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

With the rapid evolution of global autonomous driving technology, the demand for its core sensing hardware, Light Detection and Ranging (LiDAR), is escalating. As the light source part of the LiDAR system, lasers, particularly the…

The disruptive technology provided by large-scale pre-trained language models (LLMs) such as ChatGPT or GPT-4 has received significant attention in several application domains, often with an emphasis on high-level opportunities and…

Human-Computer Interaction · Computer Science 2023-06-27 Philippe J. Giabbanelli

Programming reliability algorithms is crucial for risk assessment in geotechnical engineering. This study explores the possibility of automating and accelerating this task using Generative AI based on Large Language Models (LLMs).…

Applications · Statistics 2025-06-25 Atma Sharma , Jie Zhang , Meng Lu , Shuangyi Wu , Baoxiang Li

In recent years, groundbreaking advancements in natural language processing have culminated in the emergence of powerful large language models (LLMs), which have showcased remarkable capabilities across a vast array of domains, including…

Computation and Language · Computer Science 2023-12-11 Microsoft Research AI4Science , Microsoft Azure Quantum

Recent Large Language Models (LLMs) have demonstrated significant capabilities in generating code snippets directly from problem statements. This increasingly automated process mirrors traditional human-led software development, where code…

Software Engineering · Computer Science 2024-10-23 Noble Saji Mathews , Meiyappan Nagappan

The surge in scientific submissions has placed increasing strain on the traditional peer-review process, prompting the exploration of large language models (LLMs) for automated review generation. While LLMs demonstrate competence in…

Computation and Language · Computer Science 2025-09-25 Ruochi Li , Haoxuan Zhang , Edward Gehringer , Ting Xiao , Junhua Ding , Haihua Chen

In the past decade a surge in the amount of electronic health record (EHR) data in the United States, attributed to a favorable policy environment created by the Health Information Technology for Economic and Clinical Health (HITECH) Act of…

Computation and Language · Computer Science 2025-12-08 Ivan Makohon , Mohamad Najafi , Jian Wu , Mathias Brochhausen , Yaohang Li

Genetic programming (GP) has the potential to generate explainable results, especially when used for dimensionality reduction. In this research, we investigate the potential of leveraging eXplainable AI (XAI) and large language models…

Neural and Evolutionary Computing · Computer Science 2024-03-07 Paula Maddigan , Andrew Lensen , Bing Xue

Large Language Model (LLMs) such as ChatGPT that exhibit generative AI capabilities are facing accelerated adoption and innovation. The increased presence of Generative AI (GAI) inevitably raises concerns about the risks and safety…

Computers and Society · Computer Science 2024-07-29 Jaymari Chua , Yun Li , Shiyi Yang , Chen Wang , Lina Yao

As large language models (LLMs) become more powerful and are deployed more autonomously, it will be increasingly important to prevent them from causing harmful outcomes. Researchers have investigated a variety of safety techniques for this…

Machine Learning · Computer Science 2024-07-24 Ryan Greenblatt , Buck Shlegeris , Kshitij Sachan , Fabien Roger

The field of healthcare has increasingly turned its focus towards Large Language Models (LLMs) due to their remarkable performance. However, their performance in actual clinical applications has been underexplored. Traditional evaluations…

Artificial intelligence (AI)-driven methods can vastly improve the historically costly drug design process, with various generative models already in widespread use. Generative models for de novo drug design, in particular, focus on the…

Biomolecules · Quantitative Biology 2024-06-27 Xiangru Tang , Howard Dai , Elizabeth Knight , Fang Wu , Yunyang Li , Tianxiao Li , Mark Gerstein