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Related papers: Clinical Trials Protocol Authoring using LLMs

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Clinical trial eligibility matching is a critical yet often labor-intensive and error-prone step in medical research, as it ensures that participants meet precise criteria for safe and reliable study outcomes. Recent advances in Natural…

Machine Learning · Computer Science 2025-03-04 Muhammad Talha Sharif , Abdul Rehman

Recent advances in Large Language Models (LLMs) have presented new opportunities for integrating Artificial General Intelligence (AGI) into biological research and education. This study evaluated the capabilities of leading LLMs, including…

Computation and Language · Computer Science 2023-11-15 Xinyu Gong , Jason Holmes , Yiwei Li , Zhengliang Liu , Qi Gan , Zihao Wu , Jianli Zhang , Yusong Zou , Yuxi Teng , Tian Jiang , Hongtu Zhu , Wei Liu , Tianming Liu , Yajun Yan

Recent advances in generative models, including large language models (LLMs), vision language models (VLMs), and diffusion models, have accelerated the field of natural language and image processing in medicine and marked a significant…

The emergence of Generative Artificial Intelligence (AI) and Large Language Models (LLMs) has marked a new era of Natural Language Processing (NLP), introducing unprecedented capabilities that are revolutionizing various domains. This paper…

Computation and Language · Computer Science 2024-08-26 Desta Haileselassie Hagos , Rick Battle , Danda B. Rawat

As Large Language Models (LLMs) advance in natural language processing, there is growing interest in leveraging their capabilities to simplify software interactions. In this paper, we propose a novel system that integrates LLMs for both…

Computation and Language · Computer Science 2024-09-19 Chunliang Tao , Xiaojing Fan , Yahe Yang

Generative artificial intelligence (AI) has the potential to scale up personalized tutoring through large language models (LLMs). Recent AI tutors are adapted for the tutoring task by training or prompting LLMs to follow effective…

Computation and Language · Computer Science 2025-07-30 Alexander Scarlatos , Naiming Liu , Jaewook Lee , Richard Baraniuk , Andrew Lan

The ChatGPT, a lite and conversational variant of Generative Pretrained Transformer 4 (GPT-4) developed by OpenAI, is one of the milestone Large Language Models (LLMs) with billions of parameters. LLMs have stirred up much interest among…

Computation and Language · Computer Science 2023-08-01 Hanyao Huang , Ou Zheng , Dongdong Wang , Jiayi Yin , Zijin Wang , Shengxuan Ding , Heng Yin , Chuan Xu , Renjie Yang , Qian Zheng , Bing Shi

This study examines the effect of prompt engineering on the performance of Large Language Models (LLMs) in clinical note generation. We introduce an Automatic Prompt Optimization (APO) framework to refine initial prompts and compare the…

Computation and Language · Computer Science 2024-07-08 Zonghai Yao , Ahmed Jaafar , Beining Wang , Zhichao Yang , Hong Yu

Matching patients to clinical trials is a key unsolved challenge in bringing new drugs to market. Today, identifying patients who meet a trial's eligibility criteria is highly manual, taking up to 1 hour per patient. Automated screening is…

Computation and Language · Computer Science 2024-04-11 Michael Wornow , Alejandro Lozano , Dev Dash , Jenelle Jindal , Kenneth W. Mahaffey , Nigam H. Shah

Since the release of ChatGPT and GPT-4, large language models (LLMs) and multimodal large language models (MLLMs) have attracted widespread attention for their exceptional capabilities in understanding, reasoning, and generation,…

Computation and Language · Computer Science 2024-12-31 Hanguang Xiao , Feizhong Zhou , Xingyue Liu , Tianqi Liu , Zhipeng Li , Xin Liu , Xiaoxuan Huang

With the continuous advancement of technology, artificial intelligence has significantly impacted various fields, particularly healthcare. Generative models, a key AI technology, have revolutionized medical image generation, data analysis,…

Machine Learning · Computer Science 2024-10-10 Yuan Sun , Jorge Ortiz

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

Can generative AI help us speed up the authoring of tools to help self-represented litigants? In this paper, we describe 3 approaches to automating the completion of court forms: a generative AI approach that uses GPT-3 to iteratively…

Artificial Intelligence · Computer Science 2023-12-15 Quinten Steenhuis , David Colarusso , Bryce Willey

The medical field is one of the important fields in the application of artificial intelligence technology. With the explosive growth and diversification of medical data, as well as the continuous improvement of medical needs and challenges,…

Artificial Intelligence · Computer Science 2024-03-27 Jingyu Xu , Binbin Wu , Jiaxin Huang , Yulu Gong , Yifan Zhang , Bo Liu

LLMs have transformed the execution of numerous tasks, including those in the medical domain. Among these, summarizing patient-reported outcomes (PROs) into concise natural language reports is of particular interest to clinicians, as it…

Artificial Intelligence · Computer Science 2024-12-24 Matteo Marengo , Jarod Lévy , Jean-Emmanuel Bibault

The exponential growth of text-based data in domains such as healthcare, education, and social sciences has outpaced the capacity of traditional qualitative analysis methods, which are time-intensive and prone to subjectivity. Large…

This study compares the efficacy of GPT-4 and clinalytix Medical AI in predicting the clinical risk of delirium development. Findings indicate that GPT-4 exhibited significant deficiencies in identifying positive cases and struggled to…

Computation and Language · Computer Science 2024-09-17 Mohamed Rezk , Patricia Cabanillas Silva , Fried-Michael Dahlweid

Recently, large language models (LLMs) have demonstrated excellent performance, inspiring researchers to explore their use in automating register transfer level (RTL) code generation and improving hardware design efficiency. However, the…

Computation and Language · Computer Science 2025-04-24 Peiyang Wu , Nan Guo , Xiao Xiao , Wenming Li , Xiaochun Ye , Dongrui Fan

Large Language Models (LLMs) like GPT-4, MedPaLM-2, and Med-Gemini achieve performance competitively with human experts across various medical benchmarks. However, they still face challenges in making professional diagnoses akin to…

Computation and Language · Computer Science 2024-08-23 Xiaohan Wang , Xiaoyan Yang , Yuqi Zhu , Yue Shen , Jian Wang , Peng Wei , Lei Liang , Jinjie Gu , Huajun Chen , Ningyu Zhang

This paper describes a rapid feasibility study of using GPT-4, a large language model (LLM), to (semi)automate data extraction in systematic reviews. Despite the recent surge of interest in LLMs there is still a lack of understanding of how…

Computation and Language · Computer Science 2025-02-14 Lena Schmidt , Kaitlyn Hair , Sergio Graziosi , Fiona Campbell , Claudia Kapp , Alireza Khanteymoori , Dawn Craig , Mark Engelbert , James Thomas
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