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Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Recent years have seen a rapid growth in new approaches improving the accuracy of semantic segmentation in a weakly supervised setting, i.e. with only image-level labels available for training. However, this has come at the cost of…

Computer Vision and Pattern Recognition · Computer Science 2020-05-19 Nikita Araslanov , Stefan Roth

Quantum machine learning (QML) has great potential for the analysis of chemical datasets. However, conventional quantum data-encoding schemes, such as fingerprint encoding, are generally unfeasible for the accurate representation of…

Quantum Physics · Physics 2025-11-18 Choy Boy , Edoardo Altamura , Dilhan Manawadu , Ivano Tavernelli , Stefano Mensa , David J. Wales

After learning a new object category from image-level annotations (with no object bounding boxes), humans are remarkably good at precisely localizing those objects. However, building good object localizers (i.e., detectors) currently…

Computer Vision and Pattern Recognition · Computer Science 2020-06-30 Zitian Chen , Zhiqiang Shen , Jiahui Yu , Erik Learned-Miller

The prediction of energetically stable crystal structures formed by a given chemical composition is a central problem in solid-state physics. In principle, the crystalline state of assembled atoms can be determined by optimizing the energy…

Materials Science · Physics 2022-06-01 Minoru Kusaba , Chang Liu , Ryo Yoshida

Several visualization schemes have been developed for imaging materials at the atomic level through atom probe tomography. The main shortcoming of these tools is their inability to parallel process data using multi-core computing units to…

Materials Science · Physics 2012-02-07 Hari Dahal , Michael Stukowski , Matthias J. Graf , Alexander V. Balatsky , Krishna Rajan

Every molecule ever synthesised can be drawn as a 2D skeletal diagram, yet in modern property prediction this universally available representation has received less focus in favour of molecular graphs, 3D conformers, or billion-parameter…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Aaditya Baranwal , Akshaj Gupta , Shruti Vyas , Yogesh S Rawat

Designing molecular structures with desired chemical properties is an essential task in drug discovery and material design. However, finding molecules with the optimized desired properties is still a challenging task due to combinatorial…

Biomolecules · Quantitative Biology 2023-02-02 Masatsugu Yamada , Mahito Sugiyama

The application of language models (LMs) to molecular structure generation using line notations such as SMILES and SELFIES has been well-established in the field of cheminformatics. However, extending these models to generate 3D molecular…

Machine Learning · Computer Science 2024-12-03 Kaiyuan Gao , Yusong Wang , Haoxiang Guan , Zun Wang , Qizhi Pei , John E. Hopcroft , Kun He , Lijun Wu

In this paper, we address the challenge of obtaining a comprehensive and symmetric representation of point particle groups, such as atoms in a molecule, which is crucial in physics and theoretical chemistry. The problem has become even more…

Chemical Physics · Physics 2024-02-13 Jigyasa Nigam , Sergey N. Pozdnyakov , Kevin K. Huguenin-Dumittan , Michele Ceriotti

Atomic force microscopy (AFM) is a key tool for characterising nanoscale structures, with functionalised tips now offering detailed images of the atomic structure. In parallel, AFM simulations using the particle probe model provide a…

Materials Science · Physics 2025-09-03 Jie Huang , Niko Oinonen , Fabio Priante , Filippo Federici Canova , Lauri Kurki , Chen Xu , Adam S. Foster

Chemical compound space (CCS), the set of all theoretically conceivable combinations of chemical elements and (meta-)stable geometries that make up matter, is colossal. The first principles based virtual sampling of this space, for example…

Chemical Physics · Physics 2021-06-23 Bing Huang , O. Anatole von Lilienfeld

An important yet challenging aspect of atomistic materials modeling is reconciling experimental and computational results. Conventional approaches involve generating numerous configurations through molecular dynamics or Monte Carlo…

Materials Science · Physics 2024-12-23 Tigany Zarrouk , Rina Ibragimova , Albert P. Bartók , Miguel A. Caro

The nanoparticle size and distribution information in the SEM images of silicon crystals are generally counted by manual methods. The realization of automatic machine recognition is significant in materials science. This paper proposed a…

Computer Vision and Pattern Recognition · Computer Science 2022-06-07 Ruiling Xiao , Jiayang Niu

The quest for accurate prediction of drug molecule properties poses a fundamental challenge in the realm of Artificial Intelligence Drug Discovery (AIDD). An effective representation of drug molecules emerges as a pivotal component in this…

Machine Learning · Computer Science 2024-04-22 Zhuoyuan Wang , Jiacong Mi , Shan Lu , Jieyue He

We compare the ability of a simulated annealing program and an evolutionary algorithm to find molecules with large molecular average hyperpolarizabilities. This property is an important component of nonlinear optical materials. Both…

Computational Physics · Physics 2026-02-19 Dominic Mashak , S. A. Alexander

We introduce Functional Group-Aware Representations for Small Molecules (FARM), a novel foundation model designed to bridge the gap between SMILES, natural language, and molecular graphs. The key idea behind FARM is the incorporation of…

Machine Learning · Computer Science 2026-04-29 Thao Nguyen , Kuan-Hao Huang , Ge Liu , Martin D. Burke , Ying Diao , Heng Ji

Nuclear Magnetic Resonance (NMR) spectroscopy is a cornerstone technique for determining the structures of small molecules and is especially critical in the discovery of novel natural products and clinical therapeutics. Yet, interpreting…

Machine Learning · Computer Science 2025-12-04 Ziyu Xiong , Yichi Zhang , Foyez Alauddin , Chu Xin Cheng , Joon Soo An , Mohammad R. Seyedsayamdost , Ellen D. Zhong

We propose a novel approach for image segmentation that combines Neural Ordinary Differential Equations (NODEs) and the Level Set method. Our approach parametrizes the evolution of an initial contour with a NODE that implicitly learns from…

Computer Vision and Pattern Recognition · Computer Science 2019-12-30 Rafael Valle , Fitsum Reda , Mohammad Shoeybi , Patrick Legresley , Andrew Tao , Bryan Catanzaro

In this paper we propose a new method for measuring the cross section of low yield nuclear reactions by capturing the products in a cryogenically frozen noble gas solid. Once embedded in the noble gas solid, which is optically transparent,…

Instrumentation and Detectors · Physics 2019-06-19 Benjamin Loseth , Ruoyu Fang , Dustin Frisbie , Kristen Parzuchowski , Claudio Ugalde , Jennifer Wenzl , Jaideep Taggart Singh