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Segmentation of objects in microscopy images is required for many biomedical applications. We introduce object-centric embeddings (OCEs), which embed image patches such that the spatial offsets between patches cropped from the same object…

Machine Learning · Computer Science 2023-10-13 Steffen Wolf , Manan Lalit , Henry Westmacott , Katie McDole , Jan Funke

Computational methods that operate on three-dimensional molecular structure have the potential to solve important questions in biology and chemistry. In particular, deep neural networks have gained significant attention, but their…

In the real world, a molecule is a 3D geometric structure. Compared to 1D SMILES sequences and 2D molecular graphs, 3D molecules represent the most informative molecular modality. Despite the rapid progress of autoregressive-based language…

Computational Engineering, Finance, and Science · Computer Science 2025-08-15 Lei Jiang , Shuzhou Sun , Biqing Qi , Yuchen Fu , Xiaohua Xu , Yuqiang Li , Dongzhan Zhou , Tianfan Fu

We propose a novel approach to identify one of the most significant dermoscopic criteria in the diagnosis of Cutaneous Melanoma: the Blue-whitish structure. In this paper, we achieve this goal in a Multiple Instance Learning framework using…

Computer Vision and Pattern Recognition · Computer Science 2015-07-01 Ali Madooei , Mark S. Drew , Hossein Hajimirsadeghi

Predicting molecular properties is essential for drug discovery, and computational methods can greatly enhance this process. Molecular graphs have become a focus for representation learning, with Graph Neural Networks (GNNs) widely used.…

Machine Learning · Computer Science 2025-01-31 Yan Sun , Yutong Lu , Yan Yi Li , Zihao Jing , Carson K. Leung , Pingzhao Hu

Discovery of the molecular candidates for applications in drug targets, biomolecular systems, catalysts, photovoltaics, organic electronics, and batteries, necessitates development of machine learning algorithms capable of rapid exploration…

Machine Learning · Computer Science 2023-12-12 Ayana Ghosh , Sergei V. Kalinin , Maxim A. Ziatdinov

Despite excellent progress has been made, the performance on action recognition still heavily relies on specific datasets, which are difficult to extend new action classes due to labor-intensive labeling. Moreover, the high diversity in…

Computer Vision and Pattern Recognition · Computer Science 2020-11-18 Xiaoyuan Ni , Sizhe Song , Yu-Wing Tai , Chi-Keung Tang

Logo detection in real-world scene images is an important problem with applications in advertisement and marketing. Existing general-purpose object detection methods require large training data with annotations for every logo class. These…

Computer Vision and Pattern Recognition · Computer Science 2019-07-16 Ayan Kumar Bhunia , Ankan Kumar Bhunia , Shuvozit Ghose , Abhirup Das , Partha Pratim Roy , Umapada Pal

Representation learning for images has been advanced by recent progress in more complex neural models such as the Vision Transformers and new learning theories such as the structural causal models. However, these models mainly rely on the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Zitan Chen , Zhuang Qi , Xiao Cao , Xiangxian Li , Xiangxu Meng , Lei Meng

Predicating macroscopic influences of drugs on human body, like efficacy and toxicity, is a central problem of small-molecule based drug discovery. Molecules can be represented as an undirected graph, and we can utilize graph convolution…

Machine Learning · Computer Science 2017-09-19 Junying Li , Deng Cai , Xiaofei He

Property-constrained molecular generation and editing are crucial in AI-driven drug discovery but remain hindered by two factors: (i) capturing the complex relationships between molecular structures and multiple properties remains…

Machine Learning · Computer Science 2025-11-12 Ziyu Fan , Zhijian Huang , Yahan Li , Xiaowen Hu , Siyuan Shen , Yunliang Wang , Zeyu Zhong , Shuhong Liu , Shuning Yang , Shangqian Wu , Min Wu , Lei Deng

The rapid development of deep learning has driven significant progress in image semantic segmentation - a fundamental task in computer vision. Semantic segmentation algorithms often depend on the availability of pixel-level labels (i.e.,…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Zhaozheng Chen , Qianru Sun

Observing the individual building blocks of matter is one of the primary goals of microscopy. The invention of the scanning tunneling microscope [1] revolutionized experimental surface science in that atomic-scale features on a solid-state…

Materials Science · Physics 2008-08-04 Jannik C. Meyer , C. O. Girit , M. F. Crommie , A. Zettl

Computer-driven molecular design combines the principles of chemistry, physics, and artificial intelligence to identify novel chemical compounds and materials with desired properties for a specific application. In particular,…

Chemical Physics · Physics 2023-09-04 Alessio Fallani , Leonardo Medrano Sandonas , Alexandre Tkatchenko

Different types of liquids such as water, wine and medicine appear in all aspects of daily life. However, limited attention has been given to the task, hindering the ability of robots to avoid or interact with liquids safely. The…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Jonas Li , Michelle Li , Luke Liu , Heng Fan

Rapid determination of molecular structures can greatly accelerate workflows across many chemical disciplines. However, elucidating structure using only one-dimensional (1D) NMR spectra, the most readily accessible data, remains an…

Chemical Physics · Physics 2024-08-16 Frank Hu , Michael S. Chen , Grant M. Rotskoff , Matthew W. Kanan , Thomas E. Markland

Nuclear segmentation is important and frequently demanded for pathology image analysis, yet is also challenging due to nuclear crowdedness and possible occlusion. In this paper, we present a novel bottom-up method for nuclear segmentation.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-11 Jiahui Li , Zhiqiang Hu , Shuang Yang

The atomic lensing model has been proposed as a promising method facilitating atom-counting in heterogeneous nanocrystals [KHW van den Bos et. al, Phys. Rev. Lett. 116 (2016) 246101] Here, image simulations will validate the model, which…

Materials Science · Physics 2019-02-18 K. H. W. van den Bos , L. Janssens , A. De Backer , P. D. Nellist , S. Van Aert

Image segmentation is the problem of partitioning an image into different subsets, where each subset may have a different characterization in terms of color, intensity, texture, and/or other features. Segmentation is a fundamental component…

Computer Vision and Pattern Recognition · Computer Science 2015-11-03 M. Abdelsamea

Large language models (LLMs) are increasingly recognized as powerful tools for scientific discovery, particularly in molecular science. A fundamental requirement for these models is the ability to accurately understand molecular structures,…

Machine Learning · Computer Science 2025-05-23 Yunhui Jang , Jaehyung Kim , Sungsoo Ahn
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