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We introduce a method for training neural networks to perform image or volume segmentation in which prior knowledge about the topology of the segmented object can be explicitly provided and then incorporated into the training process. By…

Computer Vision and Pattern Recognition · Computer Science 2020-09-21 James R. Clough , Nicholas Byrne , Ilkay Oksuz , Veronika A. Zimmer , Julia A. Schnabel , Andrew P. King

Deep learning-based nuclei segmentation and classification in pathology images typically rely on large-scale pixel-level manual annotations, which are costly and difficult to obtain across diverse tissues and staining conditions. To address…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Kazuya Nishimura , Ryoma Bise , Haruka Hirose , Yasuhiro Kojima

Accurate segmentation of tubular structures in medical images, such as vessels and airway trees, is crucial for computer-aided diagnosis, radiotherapy, and surgical planning. However, significant challenges exist in algorithm design when…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Yi Huang , Ke Zhang , Wei Liu , Yuanyuan Wang , Vishal M. Patel , Le Lu , Xu Han , Dakai Jin , Ke Yan

One of the biggest challenges for deep learning algorithms in medical image analysis is the indiscriminate mixing of image properties, e.g. artifacts and anatomy. These entangled image properties lead to a semantically redundant feature…

Machine Learning · Computer Science 2019-08-22 Qingjie Meng , Nick Pawlowski , Daniel Rueckert , Bernhard Kainz

We use Topological Data Analysis tools for studying the inner organization of cells in segmented images of epithelial tissues. More specifically, for each segmented image, we compute different persistence barcodes, which codify lifetime of…

Computer Vision and Pattern Recognition · Computer Science 2022-04-11 N. Atienza , M. J. Jimenez , M. Soriano-Trigueros

We propose approaches based on deep learning to localize objects in images when only a small training dataset is available and the images have low quality. That applies to many problems in medical image processing, and in particular to the…

Computer Vision and Pattern Recognition · Computer Science 2018-11-20 Aaron Pries , Peter J. Schreier , Artur Lamm , Stefan Pede , Jürgen Schmidt

Integrating high-level semantically correlated contents and low-level anatomical features is of central importance in medical image segmentation. Towards this end, recent deep learning-based medical segmentation methods have shown great…

Computer Vision and Pattern Recognition · Computer Science 2023-07-19 Chenyu You , Weicheng Dai , Yifei Min , Lawrence Staib , James S. Duncan

Segmentation is essential for medical image analysis tasks such as intervention planning, therapy guidance, diagnosis, treatment decisions. Deep learning is becoming increasingly prominent for segmentation, where the lack of annotations,…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Firat Ozdemir , Zixuan Peng , Christine Tanner , Philipp Fuernstahl , Orcun Goksel

In this work we use the persistent homology method, a technique in topological data analysis (TDA), to extract essential topological features from the data space and combine them with deep learning features for classification tasks. In TDA,…

Computer Vision and Pattern Recognition · Computer Science 2023-11-14 Mariana Dória Prata Lima , Gilson Antonio Giraldi , Gastão Florêncio Miranda Junior

Graph representation learning aims to effectively encode high-dimensional sparse graph-structured data into low-dimensional dense vectors, which is a fundamental task that has been widely studied in a range of fields, including machine…

Topological Data Analysis has grown in popularity in recent years as a way to apply tools from algebraic topology to large data sets. One of the main tools in topological data analysis is persistent homology. This paper uses undergraduate…

Algebraic Topology · Mathematics 2024-06-26 Cheyne Glass , Elizabeth Vidaurre

Modern deep neural networks have shown remarkable performance in medical image classification. However, such networks either emphasize pixel-intensity features instead of fundamental anatomical structures (e.g., those encoded by topological…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Pengfei Gu , Huimin Li , Haoteng Tang , Dongkuan , Xu , Erik Enriquez , DongChul Kim , Bin Fu , Danny Z. Chen

Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered…

Quantitative Methods · Quantitative Biology 2017-11-01 Zixuan Cang , Guo-Wei Wei

In digital pathology, segmenting densely distributed objects like glands and nuclei is crucial for downstream analysis. Since detailed pixel-wise annotations are very time-consuming, we need semi-supervised segmentation methods that can…

Image and Video Processing · Electrical Eng. & Systems 2024-07-18 Meilong Xu , Xiaoling Hu , Saumya Gupta , Shahira Abousamra , Chao Chen

Presently, topology optimization requires multiple iterations to create an optimized structure for given conditions. Among the conditions for topology optimization,the design area is one of the most important for structural design. In this…

Computational Engineering, Finance, and Science · Computer Science 2020-04-21 Keigo Nakamura , Yoshiro Suzuki

In artificial-intelligence-aided signal processing, existing deep learning models often exhibit a black-box structure, and their validity and comprehensibility remain elusive. The integration of topological methods, despite its relatively…

Machine Learning · Computer Science 2023-11-28 Pingyao Feng , Siheng Yi , Qingrui Qu , Zhiwang Yu , Yifei Zhu

The inner representation of deep neural networks (DNNs) is indecipherable, which makes it difficult to tune DNN models, control their training process, and interpret their outputs. In this paper, we propose a novel approach to investigate…

Machine Learning · Computer Science 2021-06-08 Satoru Watanabe , Hayato Yamana

Representation learning has driven major advances in natural image analysis by enabling models to acquire high-level semantic features. In microscopy imaging, however, it remains unclear what current representation learning methods actually…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Ivan Svatko , Maxime Sanchez , Ihab Bendidi , Gilles Cottrell , Auguste Genovesio

Topological correctness, i.e., the preservation of structural integrity and specific characteristics of shape, is a fundamental requirement for medical imaging tasks, such as neuron or vessel segmentation. Despite the recent surge in…

Computer Vision and Pattern Recognition · Computer Science 2024-12-20 Alexander H. Berger , Laurin Lux , Alexander Weers , Martin Menten , Daniel Rueckert , Johannes C. Paetzold

Motivated by the challenging segmentation task of pancreatic tubular networks, this paper tackles two commonly encountered problems in biomedical imaging: Topological consistency of the segmentation, and expensive or difficult annotation.…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Kasra Arnavaz , Oswin Krause , Kilian Zepf , Jelena M. Krivokapic , Silja Heilmann , Jakob Andreas Bærentzen , Pia Nyeng , Aasa Feragen