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Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is…

Machine Learning · Statistics 2016-08-17 Joseph Futoma , Mark Sendak , C. Blake Cameron , Katherine Heller

Models for segmentation of brain lesions in multi-modal MRI are commonly trained for a specific pathology using a single database with a predefined set of MRI modalities, determined by a protocol for the specific disease. This work explores…

We propose a Bayesian latent variable model to estimate covariate-assisted dependence structures across multiple modalities of multivariate data that may be observed asynchronously. This setting commonly arises in longitudinal biomedical…

Methodology · Statistics 2026-05-27 Kun Qian , Hyung G. Park

Medical data poses a daunting challenge for AI algorithms: it exists in many different modalities, experiences frequent distribution shifts, and suffers from a scarcity of examples and labels. Recent advances, including transformers and…

Benefiting from the powerful expressive capability of graphs, graph-based approaches have been popularly applied to handle multi-modal medical data and achieved impressive performance in various biomedical applications. For disease…

Machine Learning · Computer Science 2022-03-14 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yuchen Yang , Yao Zhao

In real world clinical environments, training and applying deep learning models on multi-modal medical imaging data often struggles with partially incomplete data. Standard approaches either discard missing samples, require imputation or…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Christoph Fürböck , Paul Weiser , Branko Mitic , Philipp Seeböck , Thomas Helbich , Georg Langs

While humans excel at continual learning (CL), deep neural networks (DNNs) exhibit catastrophic forgetting. A salient feature of the brain that allows effective CL is that it utilizes multiple modalities for learning and inference, which is…

Machine Learning · Computer Science 2024-05-07 Fahad Sarfraz , Bahram Zonooz , Elahe Arani

In some scenarios, a single input image may not be enough to allow the object classification. In those cases, it is crucial to explore the complementary information extracted from images presenting the same object from multiple perspectives…

Computer Vision and Pattern Recognition · Computer Science 2022-05-24 Gabriel Machado , Keiller Nogueira , Matheus Barros Pereira , Jefersson Alex dos Santos

Machine learning models built on training data with multiple modalities can reveal new insights that are not accessible through unimodal datasets. For example, cardiac magnetic resonance images (MRIs) and electrocardiograms (ECGs) are both…

Machine Learning · Computer Science 2023-12-05 Bum Chul Kwon , Samuel Friedman , Kai Xu , Steven A Lubitz , Anthony Philippakis , Puneet Batra , Patrick T Ellinor , Kenney Ng

We present a framework for generating multiple imputations for continuous data when the missing data mechanism is unknown. Imputations are generated from more than one imputation model in order to incorporate uncertainty regarding the…

Applications · Statistics 2013-01-14 Juned Siddique , Ofer Harel , Catherine M. Crespi

Synthesizing missing modalities in multi-modal magnetic resonance imaging (MRI) is vital for ensuring diagnostic completeness, particularly when full acquisitions are infeasible due to time constraints, motion artifacts, and patient…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Yue Zhang , Zhizheng Zhuo , Siyao Xu , Shan Lv , Zhaoxi Liu , Jun Qiu , Qiuli Wang , Yaou Liu , S. Kevin Zhou

Multimodal learning seeks to utilize data from multiple sources to improve the overall performance of downstream tasks. It is desirable for redundancies in the data to make multimodal systems robust to missing or corrupted observations in…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Md Kaykobad Reza , Ashley Prater-Bennette , M. Salman Asif

Multi-view learning (MVL) leverages multiple sources or views of data to enhance machine learning model performance and robustness. This approach has been successfully used in the Earth Observation (EO) domain, where views have a…

Machine Learning · Computer Science 2025-09-12 Francisco Mena , Diego Arenas , Andreas Dengel

Electronic health records (EHRs) are designed to synthesize diverse data types, including unstructured clinical notes, structured lab tests, and time-series visit data. Physicians draw on these multimodal and temporal sources of EHR data to…

Continuous-time multistate models are widely used for analyzing interval-censored data on disease progression over time. Sometimes, diseases manifest differently and what appears to be a coherent collection of symptoms is the expression of…

Methodology · Statistics 2024-10-08 Yidan Shi , Leilei Zeng , Mary E. Thompson , Suzanne L. Tyas

There is an emerging trend in the reinforcement learning for healthcare literature. In order to prepare longitudinal, irregularly sampled, clinical datasets for reinforcement learning algorithms, many researchers will resample the time…

Machine Learning · Computer Science 2019-11-19 Scott L. Fleming , Kuhan Jeyapragasan , Tony Duan , Daisy Ding , Saurabh Gombar , Nigam Shah , Emma Brunskill

In medical applications, deep learning methods are built to automate diagnostic tasks. However, a clinically relevant question that practitioners usually face, is how to predict the future trajectory of a disease (prognosis). Current…

Machine Learning · Computer Science 2021-12-08 Huy Hoang Nguyen , Simo Saarakkala , Matthew B. Blaschko , Aleksei Tiulpin

Multimodal learning assumes all modality combinations of interest are available during training to learn cross-modal correspondences. In this paper, we challenge this modality-complete assumption for multimodal learning and instead strive…

Computer Vision and Pattern Recognition · Computer Science 2023-10-26 Yunhua Zhang , Hazel Doughty , Cees G. M. Snoek

Machine learning methods in healthcare have traditionally focused on using data from a single modality, limiting their ability to effectively replicate the clinical practice of integrating multiple sources of information for improved…

Machine Learning · Computer Science 2024-02-13 Felix Krones , Umar Marikkar , Guy Parsons , Adam Szmul , Adam Mahdi

Benefiting from the powerful expressive capability of graphs, graph-based approaches have achieved impressive performance in various biomedical applications. Most existing methods tend to define the adjacency matrix among samples manually…

Machine Learning · Computer Science 2021-07-02 Shuai Zheng , Zhenfeng Zhu , Zhizhe Liu , Zhenyu Guo , Yang Liu , Yao Zhao