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In diagnostic reports, experts encode complex imaging data into clinically actionable information. They describe subtle pathological findings that are meaningful in their anatomical context. Reports follow relatively consistent structures,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Felicia Bader , Philipp Seeböck , Anastasia Bartashova , Ulrike Attenberger , Georg Langs

Clinical robustness is critical to the safe deployment of medical Large Language Models (LLMs), but key questions remain about how LLMs and humans may differ in response to the real-world variability typified by clinical settings. To…

Artificial Intelligence · Computer Science 2025-06-23 Abinitha Gourabathina , Yuexing Hao , Walter Gerych , Marzyeh Ghassemi

As advances in large language models (LLMs) and multimodal techniques continue to mature, the development of general-purpose multimodal large language models (MLLMs) has surged, offering significant applications in interpreting natural…

Computer Vision and Pattern Recognition · Computer Science 2024-02-20 Yuxuan Sun , Chenglu Zhu , Sunyi Zheng , Kai Zhang , Lin Sun , Zhongyi Shui , Yunlong Zhang , Honglin Li , Lin Yang

Vision--language models (VLMs) show promise for clinical decision support in radiology because they enable joint reasoning over radiological images and clinical text, thereby leveraging complementary clinical information. However,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Haozhe Luo , Shelley Zixin Shu , Ziyu Zhou , Robert Berke , Mauricio Reyes

Pathology deals with the practice of discovering the reasons for disease by analyzing the body samples. The most used way in this field, is to use histology which is basically studying and viewing microscopic structures of cell and tissues.…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Virender Ranga , Shivam Gupta , Priyansh Agrawal , Jyoti Meena

Recent advances in prototypical learning have shown remarkable potential to provide useful decision interpretations associating activation maps and predictions with class-specific training prototypes. Such prototypical learning has been…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Chong Wang , Fengbei Liu , Yuanhong Chen , Helen Frazer , Gustavo Carneiro

In multilingual healthcare environments, automatic disease diagnosis from clinical text remains a challenging task due to the scarcity of annotated medical data in low-resource languages and the linguistic variability across populations.…

Computation and Language · Computer Science 2025-09-26 Ayan Sar , Pranav Singh Puri , Sumit Aich , Tanupriya Choudhury , Abhijit Kumar

Vision-language models (VLMs) have demonstrated strong cross-modal capabilities, yet most work remains limited to 2D data and assumes binary supervision (i.e., positive vs. negative pairs), overlooking the continuous and structured…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Ailar Mahdizadeh , Puria Azadi Moghadam , Xiangteng He , Shahriar Mirabbasi , Panos Nasiopoulos , Leonid Sigal

We present ViDRiP-LLaVA, the first large multimodal model (LMM) in computational pathology that integrates three distinct image scenarios, including single patch images, automatically segmented pathology video clips, and manually segmented…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Trinh T. L. Vuong , Jin Tae Kwak

Medical image classifiers detect gastrointestinal diseases well, but they do not explain their decisions. Large language models can generate clinical text, yet they struggle with visual reasoning and often produce unstable or incorrect…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Md. Najib Hasan , Imran Ahmad , Sourav Basak Shuvo , Md. Mahadi Hasan Ankon , Sunanda Das , Nazmul Siddique , Hui Wang

The previous advancements in pathology image understanding primarily involved developing models tailored to specific tasks. Recent studies has demonstrated that the large vision-language model can enhance the performance of various…

Artificial Intelligence · Computer Science 2024-08-20 Dawei Dai , Yuanhui Zhang , Long Xu , Qianlan Yang , Xiaojing Shen , Shuyin Xia , Guoyin Wang

Oral mucosal diseases such as leukoplakia, oral lichen planus, and recurrent aphthous ulcers exhibit diverse and overlapping visual features, making diagnosis challenging for non-specialists. While vision-language models (VLMs) have shown…

Quantitative Methods · Quantitative Biology 2025-10-17 Jia Zhang , Bodong Du , Yitong Miao , Dongwei Sun , Xiangyong Cao

Few-shot medical image semantic segmentation is of paramount importance in the domain of medical image analysis. However, existing methodologies grapple with the challenge of data scarcity during the training phase, leading to over-fitting.…

Computer Vision and Pattern Recognition · Computer Science 2023-07-20 Zhaoxin Fan , Puquan Pan , Zeren Zhang , Ce Chen , Tianyang Wang , Siyang Zheng , Min Xu

Large Language Models (LLMs) have been shown to encode clinical knowledge. Many evaluations, however, rely on structured question-answer benchmarks, overlooking critical challenges of interpreting and reasoning about unstructured clinical…

Computation and Language · Computer Science 2026-04-01 Meghal Dani , Muthu Jeyanthi Prakash , Filip Rosa , Zeynep Akata , Stefanie Liebe

In this paper, we address the challenge of few-shot classification in histopathology whole slide images (WSIs) by utilizing foundational vision-language models (VLMs) and slide-level prompt learning. Given the gigapixel scale of WSIs,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Devavrat Tomar , Guillaume Vray , Dwarikanath Mahapatra , Sudipta Roy , Jean-Philippe Thiran , Behzad Bozorgtabar

Neuroblastoma (NB), a leading cause of childhood cancer mortality, exhibits significant histopathological variability, necessitating precise subtyping for accurate prognosis and treatment. Traditional diagnostic methods rely on subjective…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Huangwei Chen , Yifei Chen , Zhenyu Yan , Mingyang Ding , Chenlei Li , Zhu Zhu , Feiwei Qin

Pseudo-healthy synthesis is the task of creating a subject-specific `healthy' image from a pathological one. Such images can be helpful in tasks such as anomaly detection and understanding changes induced by pathology and disease. In this…

Image and Video Processing · Electrical Eng. & Systems 2021-06-21 Tian Xia , Agisilaos Chartsias , Sotirios A. Tsaftaris

Bridging clinical diagnostic reasoning with AI remains a central challenge in medical imaging. We introduce MedCLM, an automated pipeline that converts detection datasets into large-scale medical visual question answering (VQA) data with…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Soo Yong Kim , Suin Cho , Vincent-Daniel Yun , Gyeongyeon Hwang

Pre-trained on extensive text and image corpora, current Multi-Modal Large Language Models (MLLM) have shown strong capabilities in general visual reasoning tasks. However, their performance is still lacking in physical domains that require…

Artificial Intelligence · Computer Science 2025-07-04 Erle Zhu , Yadi Liu , Zhe Zhang , Xujun Li , Jin Zhou , Xinjie Yu , Minlie Huang , Hongning Wang

Understanding disease progression is a central clinical challenge with direct implications for early diagnosis and personalized treatment. While recent generative approaches have attempted to model progression, key mismatches remain:…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Hao Chen , Rui Yin , Yifan Chen , Qi Chen , Chao Li