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We construct efficient surrogate models for parametric forward operators arising in brain tumor growth simulations, governed by coupled semilinear parabolic reaction-diffusion systems on heterogeneous two- and three-dimensional domains. We…

Numerical Analysis · Mathematics 2026-03-17 Asikul Islam , Md Rezwan Bin Mizan , Maxim Olshanskii , Andreas Mang

In this article, we continue our mathematical study of organic solar cells (OSCs) and propose a two-scale (micro- and macro-scale) model of heterojunction OSCs with interface geometries characterized by an arbitrarily complex morphology.…

Numerical Analysis · Mathematics 2012-07-02 Carlo de Falco , Matteo Porro , Riccardo Sacco , Maurizio Verri

Epithelial cell monolayers show remarkable displacement and velocity correlations over distances of ten or more cell sizes that are reminiscent of supercooled liquids and active nematics. We show that many observed features can be described…

Soft Condensed Matter · Physics 2020-04-22 Silke Henkes , Kaja Kostanjevec , J. Martin Collinson , Rastko Sknepnek , Eric Bertin

Free boundaries of biofilms advancing on surfaces evolve according to conservation laws coupled with systems of partial differential equations for velocities, pressures and chemicals affecting cell behavior. Thin film approximations lead to…

Analysis of PDEs · Mathematics 2024-03-18 Ana Carpio , Gema Duro

Growth (and resorption) of biological tissue is formulated in the continuum setting. The treatment is macroscopic, rather than cellular or sub-cellular. Certain assumptions that are central to classical continuum mechanics are revisited,…

Quantitative Methods · Quantitative Biology 2015-06-26 K. Garikipati , E. M. Arruda , K. Grosh , H. Narayanan , S. Calve

This work presents a physics-conditioned latent diffusion model tailored for dynamical downscaling of atmospheric data, with a focus on reconstructing high-resolution 2-m temperature fields. Building upon a pre-existing diffusion…

Machine Learning · Computer Science 2025-10-29 Paul Rosu , Muchang Bahng , Erick Jiang , Rico Zhu , Vahid Tarokh

Organogenesis involves large deformations and complex shape changes that require elaborate mechanical regulation. Models of tissue biomechanics have been introduced to account for the coupling between mechanical response and biochemical…

Soft Condensed Matter · Physics 2025-04-16 Patrick W. Alford , Luiza Angheluta , Jorge Vinals

Transport-dominated partial differential equation models have been used extensively over the past two decades to describe various collective migration phenomena in cell biology and ecology. To understand the behaviour of these models (and…

Numerical Analysis · Mathematics 2025-05-05 Johan Marguet , Raluca Eftimie , Alexei Lozinski

Starting with sets of disorganized observations of spatially varying and temporally evolving systems, obtained at different (also disorganized) sets of parameters, we demonstrate the data-driven derivation of parameter dependent,…

Dynamical Systems · Mathematics 2022-04-27 David W. Sroczynski , Felix P. Kemeth , Ronald R. Coifman , Ioannis G. Kevrekidis

We consider a strongly heterogeneous medium saturated by an incompressible viscous fluid as it appears in geomechanical modeling. This poroelasticity problem suffers from rapidly oscillating material parameters, which calls for a thorough…

Numerical Analysis · Mathematics 2018-12-27 Robert Altmann , Eric Chung , Roland Maier , Daniel Peterseim , Sai-Mang Pun

In this paper we propose two numerical algorithms to solve a coupled PDE-ODE system which models a slow vehicle (bottleneck) moving on a road together with other cars. The resulting system is fully coupled because the dynamics of the slow…

Dynamical Systems · Mathematics 2021-03-22 Gabriella Bretti , Emiliano Cristiani , Corrado Lattanzio , Amelio Maurizi , Benedetto Piccoli

In Part I of this article we have developed a novel mechanobiological model of a Tissue Engineering process that accounts for the mechanisms through which an isotropic or anisotropic adherence condition regulates the active functions of the…

Numerical Analysis · Mathematics 2015-12-14 Chiara Lelli , Riccardo Sacco , Paola Causin , Manuela T. Raimondi

We propose an image restoration algorithm that can control the perceptual quality and/or the mean square error (MSE) of any pre-trained model, trading one over the other at test time. Our algorithm is few-shot: Given about a dozen images…

Artificial Intelligence · Computer Science 2024-08-13 Theo Adrai , Guy Ohayon , Tomer Michaeli , Michael Elad

We present the novel numerical model GeoChemFoam, a multiphase reactive transport solver for simulations on complex pore geometries, including microfluidic devices and micro-CT images. The geochemical model includes bulk and surface…

Fluid Dynamics · Physics 2021-03-08 Julien Maes , Hannah P. Menke

We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective…

Soft Condensed Matter · Physics 2018-11-20 Pranav Madhikar , Jan Åström , Björn Baumeier , Mikko Karttunen

We derive the full kinetic equations describing the evolution of the probability density distribution for a structured population such as cells distributed according to their ages and sizes. The kinetic equations for such a "sizer-timer"…

Populations and Evolution · Quantitative Biology 2026-05-12 Mingtao Xia , Tom Chou

We develop a semi-discrete optimal transport scheme for the compressible semi-geostrophic equations, a system that plays an important role in modelling large-scale atmospheric dynamics and frontogenesis. Unlike the incompressible case, the…

Numerical Analysis · Mathematics 2026-03-10 Théo Lavier , Beatrice Pelloni

In this work, we present a method for simulating the large-scale deformation and crumpling of thin, elastoplastic sheets. Motivated by the physical behavior of thin sheets during crumpling, two different formulations of the governing…

Soft Condensed Matter · Physics 2023-07-10 Jovana Andrejevic , Chris H. Rycroft

Bone is a living material. It adapts, in an optimal sense, to loading by changing its density and trabeculae architecture - a process termed remodelling. Implanted orthopaedic devices can significantly alter the loading on the surrounding…

Tissues and Organs · Quantitative Biology 2017-05-24 H. Liedtke , A. T. McBride , S. Sivarasu , S. Roche

In this paper, we study a hydrodynamic phase-field system modeling the deformation of functionalized membranes in incompressible viscous fluids. The governing PDE system consists of the Navier-Stokes equations coupled with a convective…

Analysis of PDEs · Mathematics 2022-06-22 Hao Wu , Yuchen Yang