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Predicting clinical outcomes to anti-cancer drugs on a personalized basis is challenging in cancer treatment due to the heterogeneity of tumors. Traditional computational efforts have been made to model the effect of drug response on…

Machine Learning · Computer Science 2022-07-12 Jie Gao , Jing Hu , Wanqing Sun , Yili Shen , Xiaonan Zhang , Xiaomin Fang , Fan Wang , Guodong Zhao

Variational quantum algorithms are tailored to perform within the constraints of current quantum devices, yet they are limited by performance-degrading errors. In this study, we consider a noise model that reflects realistic gate errors…

The prediction modeling of drug-target interactions is crucial to drug discovery and design, which has seen rapid advancements owing to deep learning technologies. Recently developed methods, such as those based on graph neural networks…

Quantitative Methods · Quantitative Biology 2025-11-19 Xinnan Zhang , Jialin Wu , Junyi Xie , Tianlong Chen , Kaixiong Zhou

Current quantum neural networks suffer from extreme sensitivity to both adversarial perturbations and hardware noise, creating a significant barrier to real-world deployment. Existing robustness techniques typically sacrifice clean accuracy…

Quantum Physics · Physics 2026-01-27 Mohamed Afane , Quanjiang Long , Haoting Shen , Ying Mao , Junaid Farooq , Ying Wang , Juntao Chen

Multimodal deep learning (MDL) has emerged as a transformative approach in computational pathology. By integrating complementary information from multiple data sources, MDL models have demonstrated superior predictive performance across…

Quantitative Methods · Quantitative Biology 2025-11-17 Seth Alain Chang , Muhammad Mueez Amjad , Noorul Wahab , Ethar Alzaid , Nasir Rajpoot , Adam Shephard

Vector-quantized based models have recently demonstrated strong potential for visual prior modeling. However, existing VQ-based methods simply encode visual features with nearest codebook items and train index predictor with code-level…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Qifan Li , Jiale Zou , Jinhua Zhang , Wei Long , Xingyu Zhou , Shuhang Gu

In the lead up to fault tolerance, the utility of quantum computing will be determined by how adequately the effects of noise can be circumvented in quantum algorithms. Hybrid quantum-classical algorithms such as the variational quantum…

Predicting cross-sectional stock returns is challenging due to low signal-to-noise ratios and evolving market regimes. Classical factor models offer interpretability but limited flexibility, while deep learning models achieve strong…

Machine Learning · Computer Science 2026-05-14 Namhyoung Kim , Jae Wook Song

The vector quantization is a widely used method to map continuous representation to discrete space and has important application in tokenization for generative mode, bottlenecking information and many other tasks in machine learning. Vector…

Machine Learning · Computer Science 2024-10-15 Mingyuan Yan , Jiawei Wu , Rushi Shah , Dianbo Liu

Variational Quantum Algorithms (VQAs) are promising methods for solving combinatorial optimization problems on noisy intermediate-scale quantum (NISQ) devices. However, benchmarking VQAs is difficult due to their stochastic behavior and the…

The Variational Quantum Eigensolver (VQE) is a hybrid quantum-classical algorithm for preparing ground states in the current era of noisy devices. The classical component of the algorithm requires a large number of measurements on…

Quantum Physics · Physics 2025-03-27 Akib Karim , Shaobo Zhang , Muhammad Usman

This paper describes an entropy regularization term for vector quantization (VQ) based on the analysis of persistent homology of the VQ embeddings. Higher embedding entropy positively correlates with higher codebook utilization, mitigating…

Machine Learning · Computer Science 2022-11-29 Ivan Volkov

Deep neural networks (DNNs) have achieved tremendous success in computer vision, natural language processing, and scientific and engineering domains. However, DNNs can make unexpected, incorrect, yet overconfident predictions, leading to…

Machine Learning · Computer Science 2025-12-16 Wenchong He , Zhe Jiang , Tingsong Xiao , Zelin Xu , Yukun Li

The aim is to create a method for accurately estimating the duration of post-cancer treatment, particularly focused on chemotherapy, to optimize patient care and recovery. This initiative seeks to improve the effectiveness of cancer…

Computers and Society · Computer Science 2025-04-24 Joyee Chakraborty , Mazahrul Islam Tohin , Danbir Rashid , Tanjil Ahmed Tanmoy , Md. Jehadul Islam Mony

Quantum computers are expected to be highly beneficial for chemistry simulations, promising significant improvements in accuracy and speed. The most prominent algorithm for chemistry simulations on NISQ devices is the Variational Quantum…

Quantum Physics · Physics 2022-09-27 Marita Oliv , Andrea Matic , Thomas Messerer , Jeanette Miriam Lorenz

Quantum mechanics has introduced a new theoretical framework for the study of molecules, enabling the prediction of properties and dynamics through the solution of the Schr\"odinger equation applied to these systems. However, solving this…

Variational quantum algorithms (VQAs) are promising methods that leverage noisy quantum computers and classical computing techniques for practical applications. In VQAs, the classical optimizers such as gradient-based optimizers are…

Quantum Physics · Physics 2021-06-22 Yudai Suzuki , Hiroshi Yano , Rudy Raymond , Naoki Yamamoto

Quantile regression (QR) is a powerful tool for estimating one or more conditional quantiles of a target variable $\mathrm{Y}$ given explanatory features $\boldsymbol{\mathrm{X}}$. A limitation of QR is that it is only defined for scalar…

Computation · Statistics 2023-06-05 Aviv A. Rosenberg , Sanketh Vedula , Yaniv Romano , Alex M. Bronstein

Quantum sensing exploits non-classical effects to overcome limitations of classical sensors, with applications ranging from gravitational-wave detection to nanoscale imaging. However, practical quantum sensors built on noisy…

Quantum Physics · Physics 2025-05-30 Ivana Nikoloska , Hamdi Joudeh , Ruud van Sloun , Osvaldo Simeone

Path integral control is an effective method in cancer drug treatment, providing a structured approach to handle the complexities and unpredictability of tumor behavior. Utilizing mathematical principles from physics, this technique…

Tissues and Organs · Quantitative Biology 2024-12-19 Jason Sonith