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Pseudo-healthy synthesis is the task of creating a subject-specific `healthy' image from a pathological one. Such images can be helpful in tasks such as anomaly detection and understanding changes induced by pathology and disease. In this…

Image and Video Processing · Electrical Eng. & Systems 2021-06-21 Tian Xia , Agisilaos Chartsias , Sotirios A. Tsaftaris

For measuring the strength of visually-observed subpopulation differences, the Population Difference Criterion is proposed to assess the statistical significance of visually observed subpopulation differences. It addresses the following…

Methodology · Statistics 2023-09-21 Xi Yang , Jan Hannig , Katherine A. Hoadley , Iain Carmichael , J. S. Marron

Medical image segmentation plays an important role in clinical decision making, treatment planning, and disease tracking. However, it still faces two major challenges. On the one hand, there is often a ``soft boundary'' between foreground…

Image and Video Processing · Electrical Eng. & Systems 2024-12-12 Mengqi Lei , Haochen Wu , Xinhua Lv , Xin Wang

In biomedical Subgroup Discovery, practitioners are interested in discovering interpretable and homogeneous subgroups within a group of patients. In this paper, assuming that healthy subjects (i.e., controls) share common but irrelevant…

Machine Learning · Computer Science 2026-05-21 Robin Louiset , Edouard Duchesnay , Benoit Dufumier , Antoine Grigis , Pietro Gori

The existing barely-supervised medical image segmentation (BSS) methods, adopting a registration-segmentation paradigm, aim to learn from data with very few annotations to mitigate the extreme label scarcity problem. However, this paradigm…

Computer Vision and Pattern Recognition · Computer Science 2024-07-09 Junming Su , Zhiqiang Shen , Peng Cao , Jinzhu Yang , Osmar R. Zaiane

Although self-supervised learning enables us to bootstrap the training by exploiting unlabeled data, the generic self-supervised methods for natural images do not sufficiently incorporate the context. For medical images, a desirable method…

Image and Video Processing · Electrical Eng. & Systems 2022-07-08 Li Sun , Ke Yu , Kayhan Batmanghelich

Identifying subtle phenotypic variations in cellular images is critical for advancing biological research and accelerating drug discovery. These variations are often masked by the inherent cellular heterogeneity, making it challenging to…

Computer Vision and Pattern Recognition · Computer Science 2026-01-28 Anis Bourou , Biel Castaño Segade , Thomas Boyer , Valérie Mezger , Auguste Genovesio

Deep neural two-sample tests have recently shown strong power for detecting distributional differences between groups, yet their black-box nature limits interpretability and practical adoption in biomedical analysis. Moreover, most existing…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Masoumeh Javanbakhat , Piotr Komorowski , Dilyara Bareeva , Wei-Chang Lai , Wojciech Samek , Christoph Lippert

Image retargeting is the task of making images capable of being displayed on screens with different sizes. This work should be done so that high-level visual information and low-level features such as texture remain as intact as possible to…

Computer Vision and Pattern Recognition · Computer Science 2019-10-18 Mahdi Ahmadi , Nader Karimi , Shadrokh Samavi

Supervised learning method requires a large volume of annotated datasets. Collecting such datasets is time-consuming and expensive. Until now, very few annotated COVID-19 imaging datasets are available. Although self-supervised learning…

Image and Video Processing · Electrical Eng. & Systems 2020-12-14 Li Sun , Ke Yu , Kayhan Batmanghelich

AI models for medical diagnosis often exhibit uneven performance across patient populations due to heterogeneity in disease prevalence, imaging appearance, and clinical risk profiles. Existing algorithmic fairness approaches typically seek…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Gelei Xu , Yuying Duan , Jun Xia , Ruining Deng , Wei Jin , Yiyu Shi

Different visual patterns appear with different frequencies in the world: e.g., beach balls appear on sand more often than they do on a road. These statistics are reflected in vision datasets, and as a result trained models more easily…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Xinran Liang , Esin Tureci , Prachi Sinha , Ye Zhu , Vikram V. Ramaswamy , Olga Russakovsky

Fully supervised segmentation methods require a large training cohort of already segmented images, providing information at the pixel level of each image. We present a method to automatically segment and model pathologies in medical images,…

Computer Vision and Pattern Recognition · Computer Science 2019-08-22 Simon Andermatt , Antal Horváth , Simon Pezold , Philippe Cattin

Medical images are often used to detect and characterize pathology and disease; however, automatically identifying and segmenting pathology in medical images is challenging because the appearance of pathology across diseases varies widely.…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Jacob C. Reinhold , Yufan He , Shizhong Han , Yunqiang Chen , Dashan Gao , Junghoon Lee , Jerry L. Prince , Aaron Carass

In pathology image analysis, obtaining and maintaining high-quality annotated samples is an extremely labor-intensive task. To overcome this challenge, mixing-based methods have emerged as effective alternatives to traditional preprocessing…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Tianyi Zhang , Zhiling Yan , Chunhui Li , Nan Ying , Yanli Lei , Yunlu Feng , Yu Zhao , Guanglei Zhang

We study the problem of understanding where two populations differ within a feature space, which we formalize in the concept of a differential subgroup: a subset of individuals from both populations who, despite sharing similar…

Machine Learning · Computer Science 2026-05-01 Sascha Xu , Jilles Vreeken

While human observers are able to cope with variations in color and appearance of histological stains, digital pathology algorithms commonly require a well-normalized setting to achieve peak performance, especially when a limited amount of…

Computer Vision and Pattern Recognition · Computer Science 2017-08-15 Daniel Bug , Steffen Schneider , Anne Grote , Eva Oswald , Friedrich Feuerhake , Julia Schüler , Dorit Merhof

We propose Context Diffusion, a diffusion-based framework that enables image generation models to learn from visual examples presented in context. Recent work tackles such in-context learning for image generation, where a query image is…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Ivona Najdenkoska , Animesh Sinha , Abhimanyu Dubey , Dhruv Mahajan , Vignesh Ramanathan , Filip Radenovic

The lack of large labeled medical imaging datasets, along with significant inter-individual variability compared to clinically established disease classes, poses significant challenges in exploiting medical imaging information in a…

Computer Vision and Pattern Recognition · Computer Science 2022-09-27 Matteo Ferrante , Tommaso Boccato , Simeon Spasov , Andrea Duggento , Nicola Toschi

Segmentation of pathological images is essential for accurate disease diagnosis. The quality of manual labels plays a critical role in segmentation accuracy; yet, in practice, the labels between pathologists could be inconsistent, thus…

Image and Video Processing · Electrical Eng. & Systems 2021-04-07 Li Xiao , Yinhao Li , Luxi Qv , Xinxia Tian , Yijie Peng , S. Kevin Zhou
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