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About 90 percent of people with Parkinson's disease (PD) experience decreased functional communication due to the presence of voice and speech disorders associated with dysarthria that can be characterized by monotony of pitch (or…

Computers and Society · Computer Science 2016-12-23 Harishchandra Dubey , Jon C. Goldberg , Mohammadreza Abtahi , Leslie Mahler , Kunal Mankodiya

Objective: This study aimed to evaluate which voice features can predict health deterioration in patients with chronic HF. Background: Heart failure (HF) is a chronic condition with progressive deterioration and acute decompensations, often…

Parkinson's disease is a neurodegenerative disorder that can be very tricky to diagnose and treat. Such early symptoms can include tremors, wheezy breathing, and changes in voice quality as critical indicators of neural damage. Notably,…

Sound · Computer Science 2025-11-20 Abishek Karthik , Pandiyaraju V , Dominic Savio M , Rohit Swaminathan S

Speech quality is one of the main foci of speech-related research, where it is frequently studied with speech intelligibility, another essential measurement. Band-level perceptual speech intelligibility, however, has been studied…

Audio and Speech Processing · Electrical Eng. & Systems 2025-11-05 Junyi Fan , Donald S. Williamson

Speaker embeddings are widely used in speaker verification systems and other applications where it is useful to characterise the voice of a speaker with a fixed-length vector. These embeddings tend to be treated as "black box" encodings,…

Sound · Computer Science 2025-10-21 Mark Huckvale

Using speech samples as a biomarker is a promising avenue for detecting and monitoring the progression of Parkinson's disease (PD), but there is considerable disagreement in the literature about how best to collect and analyze such data.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-07-24 Peter Plantinga , Briac Cordelle , Dominique Louër , Mirco Ravanelli , Denise Klein

Falls are detrimental to people with Parkinson's Disease (PD) because of the potentially severe consequences to the patients' quality of life. While many studies have attempted to predict falls/non-falls, this study aimed to determine…

Applications · Statistics 2019-10-07 Sarini Abdullah , James McGree , Nicole White , Kerrie Mengersen , Graham Kerr

Parkinson's disease is a neurodegenerative disorder characterized by the presence of different motor impairments. Information from speech, handwriting, and gait signals have been considered to evaluate the neurological state of the…

Audio and Speech Processing · Electrical Eng. & Systems 2020-06-14 J. C. Vasquez-Correa , T. Bocklet , J. R. Orozco-Arroyave , E. Nöth

Parkinson disease (PD)'s speech recognition is an effective way for its diagnosis, which has become a hot and difficult research area in recent years. As we know, there are large corpuses (segments) within one subject. However, too large…

Sound · Computer Science 2021-11-18 Yiwen Wang , Fan Li , Xiaoheng Zhang , Pin Wang , Yongming Li

Parkinsons disease (PD) diagnosis is challenging due to subtle early clinical signs. F-DOPA PET is commonly used for early PD diagnosis. We explore the potential of machine-learning (ML) based EEG features extracted from single-channel EEG…

Neurons and Cognition · Quantitative Biology 2023-08-08 Lior Molcho , Neta B. Maimon , Neomi Hezi , Talya Zeimer , Nathan Intrator , Tanya Gurevich

PD is linked to faster brain aging. Sex is recognized as an important factor in PD, such that males are twice as likely as females to have the disease and have more severe symptoms and a faster progression rate. Despite previous research,…

Neurons and Cognition · Quantitative Biology 2023-09-20 Iman Beheshti , Samuel Booth , Ji Hyun Ko

Parkinsons disease (PD) is a debilitating motor system disorder characterized by progressive loss of movement, tremors, and speech slurring. PD is due to the loss of dopamine-producing brain cells, and symptoms only worsen over time, making…

Neurons and Cognition · Quantitative Biology 2014-05-07 Pooja Chandrashekar

This article focuses on the research tool for investigating the fundamental frequencies of voiced sounds. We introduce an objective and informative measurement method of pitch extractors' response to frequency-modulated tones. The method…

Hypernasality is a common characteristic symptom across many motor-speech disorders. For voiced sounds, hypernasality introduces an additional resonance in the lower frequencies and, for unvoiced sounds, there is reduced articulatory…

Audio and Speech Processing · Electrical Eng. & Systems 2020-09-14 Michael Saxon , Ayush Tripathi , Yishan Jiao , Julie Liss , Visar Berisha

Assessment of voice signals has long been performed with the assumption of periodicity as this facilitates analysis. Near periodicity of normal voice signals makes short-time harmonic modeling an appealing choice to extract vocal feature…

Audio and Speech Processing · Electrical Eng. & Systems 2022-02-10 Takeshi Ikuma , Andrew J. McWhorter , Lacey Adkins , Melda Kunduk

Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing…

Neurons and Cognition · Quantitative Biology 2026-04-01 Siyuan Du , Siyi Li , Shuwei Bai , Ang Li , Haolin Li , Mingqing Xiao , Yang Pan , Dongsheng Li , Weidi Xie , Yanfeng Wang , Ya Zhang , Chencheng Zhang , Jiangchao Yao

Recent advances in speech foundation models (SFMs) have enabled the direct processing of spoken language from raw audio, bypassing intermediate textual representations. This capability allows SFMs to be exposed to, and potentially respond…

Audio and Speech Processing · Electrical Eng. & Systems 2025-10-30 Harm Lameris , Shree Harsha Bokkahalli Satish , Joakim Gustafson , Éva Székely

Parkinson's disease (PD) is a slowly progressing neurodegenerative disease with early manifestation of motor signs. Objective measurements of motor signs are of vital importance for diagnosing, monitoring and developing disease modifying…

Dementia affects cognitive functions of adults, including memory, language, and behaviour. Standard diagnostic biomarkers such as MRI are costly, whilst neuropsychological tests suffer from sensitivity issues in detecting dementia onset.…

Computation and Language · Computer Science 2023-12-27 Dimitris Gkoumas , Bo Wang , Adam Tsakalidis , Maria Wolters , Arkaitz Zubiaga , Matthew Purver , Maria Liakata

This study examines pitch contours as a unifying semantic construct prevalent across various audio domains including music, speech, bioacoustics, and everyday sounds. Analyzing pitch contours offers insights into the universal role of pitch…

Audio and Speech Processing · Electrical Eng. & Systems 2025-03-26 Jakob Abeßer , Simon Schwär , Meinard Müller