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Superheated perfluorocarbon nanodroplets are emerging ultrasound imaging contrast agents boasting biocompatible components, unique phase-change dynamics, and therapeutic loading capabilities. Upon exposure to a sufficiently high intensity…
Drug delivery devices based on nanocomposite membranes containing thermoresponsive nanogels and superparamagnetic nanoparticles have been demonstrated to provide reversible, on-off drug release upon application (and removal) of an…
The prompt identification of pancreatic cancer symptoms is an ongoing clinical challenge, often leading to late diagnosis and poor prognosis. Tumor 'hijacking' of the pancreatic stromal structure limits the uptake of systemic…
Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off…
Among the various molecular imaging modalities, ultrasound imaging benefits from its real-time, nonionizing, and cost-effective nature. Despite its benefits, there is a dearth of methods to visualize two or more populations of contrast…
Perfluorohexane is a biocompatible material that serves as a liquid core for acoustically-responsive agents in biomedical applications. Despite its relatively widespread usage, there is a lack of experimental data determining its…
Ultrasound-vaporizable microdroplets can be exploited for targeted drug delivery. However, it requires customized microfluidic techniques able to produce monodisperse, capillary-sized and biocompatible multiple emulsions. Recent development…
A key challenge in drug delivery systems is the real time monitoring of delivered drug and subsequent response. Recent advancement in nanotechnology has enabled the design and preclinical implementation of novel drug delivery systems (DDS)…
Fluorosurfactant-stabilized microdroplets hold significant promise for a wide range of applications, owing to their biological and chemical inertness. However, conventional synthetic routes for fluorosurfactants typically require multiple…
The dynamics of polarized fluorescence in reduced nicotinamide adenine dinucleotide (NADH) at 436~nm under two-photon excitation at 720~nm by femtosecond laser pulses in alcohol dehydrogenase (ADH)-containing buffer solution has been…
The dynamics of polarized fluorescence in NADH at 460 nm under two-photon excitation at 720 nm by femtosecond laser pulses in water-methanol solutions has been studied experimentally and theoretically as a function of methanol…
Thermoresponsive hydrogels have been studied intensively for creating smart drug carriers and controlled drug delivery. Understanding the drug release kinetics and corresponding transport mechanisms of nanoparticles (NPs) in a…
The integration of magnetic nanoparticles within fibrillar structures represents an interesting avenue for the remotely controlled release of therapeutic agents. This work presents a novel drug release platform based on electrospun magnetic…
Unprecedentedly massive electrorheology has been reported for dilute graphene nanoflakes based ER fluids that have been engineered as novel, readily synthesizable polymeric gels. Polyethylene glycol based graphene gels have been synthesized…
Mechanisms for non-invasive target drug delivery using microbubbles and ultrasound have attracted growing interest. Microbubbles can be loaded with a therapeutic payload and tracked via ultrasound imaging to selectively release their…
Drug delivery systems represent a promising strategy to treat cancer and to overcome the side effects of chemotherapy. In particular, polymeric nanocontainers have attracted major interest because of their structural and morphological…
Nanoprecipitation, the rapid solvent-displacement route to nanoscale phase separation, has matured from a simple batch operation into a versatile platform for nanomaterial synthesis. This review synthesizes recent progress in…
On-demand controlled drug delivery is essential for the treatment of a wide range of chronic diseases. As the drug is released at the time when required, its efficacy is boosted and the side effects are minimized. However, so far, drug…
Block copolymers often create droplets when placed on a substrate. Such nanostructured droplets can be arranged into regular microstructured arrays, thereby forming hierarchically organized materials that can be used in microelectronics,…
The ability to induce regions of high and low ionic concentration adjacent to a permeselective membrane or nanochannel subject to an externally applied electric field (a phenomenon termed concentration-polarization) has been used for a…