A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery

Todd Hoare; Jesus Santamaria; Gerardo F. Goya; Silvia Irusta; Debora Lin; Samantha Lau; Robert Padera; Robert Langer; Daniel S. Kohane

A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery

Materials Science 2011-03-25 v1

Authors: Todd Hoare , Jesus Santamaria , Gerardo F. Goya , Silvia Irusta , Debora Lin , Samantha Lau , Robert Padera , Robert Langer , Daniel S. Kohane

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Abstract

Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve "on-demand" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the "on" pulse. The membranes were non-cytotoxic, biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantation.

Keywords

nanocomposite membrane drug delivery magnetic triggering thermosensitive nanogels magnetite nanoparticles on-demand release biocompatibility

Cite

@article{arxiv.1103.4711,
  title  = {A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery},
  author = {Todd Hoare and Jesus Santamaria and Gerardo F. Goya and Silvia Irusta and Debora Lin and Samantha Lau and Robert Padera and Robert Langer and Daniel S. Kohane},
  journal= {arXiv preprint arXiv:1103.4711},
  year   = {2011}
}

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12 pages, 4 figures

A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery

Abstract

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