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We report a simple, rapid, and quantitative wide-field technique to measure the optical extinction $\sigma_{\rm ext}$ and scattering $\sigma_{\rm sca}$ cross-section of single nanoparticles using wide-field microscopy enabling simultaneous…

Materials Science · Physics 2013-04-05 Lukas M Payne , Wolfgang Langbein , Paola Borri

We present a new, high-speed technique to track the three-dimensional translation and rotation of non-spherical colloidal particles. We capture digital holograms of micrometer-scale silica rods and sub-micrometer-scale Janus particles…

There is considerable evidence that action potentials are accompanied by "intrinsic optical signals", such as a nanometer-scale motion of the cell membrane. Here we present ChiSCAT, a technically simple imaging scheme that detects such…

Fluid flow through intricate confining geometries often exhibits complex behaviors, certainly in porous materials, e.g. in groundwater flows or the operation of filtration devices and porous catalysts. However, it has remained extremely…

This paper addresses the task of tracking Lissajous trajectories in the presence of quantized positioning sensors. To do so, theoretical results on tracking of continuous time periodic signals in the presence of output quantization are…

Systems and Control · Electrical Eng. & Systems 2024-04-09 Matheus Lohse , Rafael S. Castro , Aurelio T. Salton , Minyue Fu

Comprehensive characterization of nanomaterials for medical applications is a challenging and complex task due to the multitude of parameters which need to be taken into consideration in a broad range of conditions. Routine methods such as…

This work addresses the critical problem of tracking fast-moving objects through strongly scattering media in a low-light environment. Different from existing approaches that use frame-based cameras with fixed exposure times, which trade…

Computer Vision and Pattern Recognition · Computer Science 2026-04-29 Yuqing Cao , Shuo Zhu , Rongzhou Chen , Jingyan Chen , Ni Chen , Edmund Y. Lam

Magnetic nanoparticles offer unique potential for various technological, biomedical, or environmental applications thanks to the size-, shape- and material-dependent tunability of their magnetic properties. To optimize particles for a…

Microparticles ranging from sub-microns to millimeter in size are a common form of matter in magnetic fusion environment, and they are highly mobile due to their small mass. Different forces in addition to gravity can affect their motion…

Instrumentation and Detectors · Physics 2018-08-01 Pinghan Chu , Bradley T. Wolfe , Zhehui Wang

Optical sensing is one of the key-enablers of modern diagnostics. Especially label-free imaging modalities hold great promise as they eliminate labeling procedures prior to analysis. However, scattering signals of nanometric particles scale…

Optics · Physics 2021-02-03 Unai Ortiz-Orruño , Ala Jo , Hakho Lee , Niek F. van Hulst , Matz Liebel

Interferometric methods for detecting the motion of a levitated nanoparticle provide a route to the quantum ground state, but such methods are currently limited by mode mismatch between the reference beam and the dipolar field scattered by…

Ultrasensitive optical detection of nanometer-scaled particles is highly desirable for applications in early-stage diagnosis of human diseases, environmental monitoring, and homeland security, but remains extremely difficult due to ultralow…

Most methods for optical visualization beyond the diffraction limit rely on fluorescence emission by molecular tags. Here, we report a method for visualization of nanostructures down to a few nanometers using a conventional bright-field…

Label-free imaging of rapidly moving, sub-diffraction sized structures has important applications in both biology and material science, as it removes the limitations associated with fluorescence tagging. However, unlabeled nanoscale…

Monitoring chemical reactions in solutions at the scale of individual entities is challenging: single particle detection requires small confocal volumes which are hardly compatible with Brownian motion, particularly when long integration…

Single-molecule microscopy has become an indispensable tool for biochemical analysis. The capability of characterizing distinct properties of individual molecules without averaging has provided us with a different perspective for the…

Applied Physics · Physics 2020-05-21 Miao-Hsuan Chien , Silvan Schmid

Accurate detection and characterization of nanoparticles within confined spaces is crucial for applications ranging from nanofluidics to biotechnology. We present a novel approach that combines interferometric scattering (iSCAT) detection…

Particle tracking is a key to single-particle-level confocal microscopy observation of colloidal suspensions, emulsions, and granular matter. The conventional tracking method has not been able to provide accurate information on the size of…

Soft Condensed Matter · Physics 2013-01-31 Mathieu Leocmach , Hajime Tanaka

Interferometric particle imaging is a widely used optical measuring technique for the sizing of poly-dispersed spherical particles like droplets and bubbles. In its conventional approach, the method is limited to forward-scattering angles…

Fluid Dynamics · Physics 2023-03-29 Christian Sax , Maximilian Dreisbach , Jochen Kriegseis