3D diffractive imaging of nanoparticle ensembles using an X-ray laser
Abstract
We report the 3D structure determination of gold nanoparticles (AuNPs) by X-ray single particle imaging (SPI). Around 10 million diffraction patterns from gold nanoparticles were measured in less than 100 hours of beam time, more than 100 times the amount of data in any single prior SPI experiment, using the new capabilities of the European X-ray free electron laser which allow measurements of 1500 frames per second. A classification and structural sorting method was developed to disentangle the heterogeneity of the particles and to obtain a resolution of better than 3 nm. With these new experimental and analytical developments, we have entered a new era for the SPI method and the path towards close-to-atomic resolution imaging of biomolecules is apparent.
Cite
@article{arxiv.2007.13597,
title = {3D diffractive imaging of nanoparticle ensembles using an X-ray laser},
author = {Kartik Ayyer and P. Lourdu Xavier and Johan Bielecki and Zhou Shen and Benedikt J. Daurer and Amit K. Samanta and Salah Awel and Richard Bean and Anton Barty and Tomas Ekeberg and Armando D. Estillore and Klaus Giewekemeyer and Mark S. Hunter and Richard A. Kirian and Henry Kirkwood and Yoonhee Kim and Jayanath Koliyadu and Holger Lange and Romain Letruin and Jannik Lübke and Andrew J. Morgan and Nils Roth and Tokushi Sato and Marcin Sikorski and Florian Schulz and John C. H. Spence and Patrik Vagovic and Tamme Wollweber and Lena Worbs and Oleksandr Yefanov and Yulong Zhuang and Filipe R. N. C. Maia and Daniel A. Horke and Jochen Küpper and N. Duane Loh and Adrian P. Mancuso and Henry N. Chapman},
journal= {arXiv preprint arXiv:2007.13597},
year = {2020}
}
Comments
25 pages, 5 main figures, 6 supplementary figures, 2 supplementary movies (link in document)