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Micro-Electro-Mechanical-Systems are complex structures, often involving nonlinearites of geometric and multiphysics nature, that are used as sensors and actuators in countless applications. Starting from full-order representations, we…

Dynamical Systems · Mathematics 2023-04-04 Giorgio Gobat , Stefania Fresca , Andrea Manzoni , Attilio Frangi

Quantitative comparison of the quality of photoacoustic image reconstruction algorithms remains a major challenge. No-reference image quality measures are often inadequate, but full-reference measures require access to an ideal reference…

Three-dimensional electrical capacitance tomography (3D-ECT) has shown promise for visualizing industrial multiphase flows. However, existing 3D-ECT approaches suffer from limited imaging resolution and lack assessment metrics, hampering…

Image and Video Processing · Electrical Eng. & Systems 2023-12-25 Shengnan Wang , Yi Li , Zhou Chen , Yunjie Yang

The challenge of translating vast, multimodal biological data into predictive and mechanistic understanding of cellular function is a central theme in modern biology. Virtual cells, or digital cellular twins, have emerged as a critical…

Quantitative Methods · Quantitative Biology 2025-09-24 Saurabh Bhardwaj , Gaurav Kumar , Haochen Yang , Shaurya Bhardwaj , Qun Wang , Minjie Shen , Yizhi Wang , Cristabelle Madona De Souza

Purpose: Digital twins are virtual interactive models of the real world, exhibiting identical behavior and properties. In surgical applications, computational analysis from digital twins can be used, for example, to enhance situational…

Axial piston pumps are indispensable power sources in high-stakes fluid power systems, including aerospace, marine, and heavy machinery applications. Their operational reliability is frequently compromised by compound faults that…

Fluid Dynamics · Physics 2026-03-17 Chang Dong , Jianfeng Tao , Chengliang Liu

Image-based computational fluid dynamics (CFD) has emerged as a powerful tool to study cardiovascular flows while 2D echocardiography (echo) is the most widely used non-invasive imaging modality for diagnosis of heart disease. Here, echo is…

The exploitation of large-scale population data has the potential to improve healthcare by discovering and understanding patterns and trends within this data. To enable high throughput analysis of cardiac imaging data automatically, a…

Image and Video Processing · Electrical Eng. & Systems 2019-01-14 Rahman Attar , Marco Pereanez , Ali Gooya , Xenia Alba , Le Zhang , Stefan K. Piechnik , Stefan Neubauer , Steffen E. Petersen , Alejandro F. Frangi

This work is motivated by personalized digital twins based on observations and physical models for treatment and prevention of Hypertension. The models commonly used are simplification of the real process and the aim is to make inference…

Methodology · Statistics 2022-01-19 Michail Spitieris , Ingelin Steinsland , Emma Ingestrom

The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostatic lesion (DIL) boost represents a significant advancement in…

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be…

Quantitative Methods · Quantitative Biology 2024-03-22 Lucas Böttcher , Luis L. Fonseca , Reinhard C. Laubenbacher

Real-time supercomputing performance analysis is a critical aspect of evaluating and optimizing computational systems in a dynamic user environment. The operation of supercomputers produce vast quantities of analytic data from multiple…

Medicine is moving from a curative discipline to a preventative discipline relying on personalised and precise treatment plans. The complex and multi level pathophysiological patterns of most diseases require a systemic medicine approach…

Computational Engineering, Finance, and Science · Computer Science 2020-07-21 Pietro Barbiero , Pietro Lió

In this study we present a novel computational model for unprecedented simulations of the whole cardiac electrophysiology. According to the heterogeneous electrophysiologic properties of the heart, the whole cardiac geometry is decomposed…

Medical Physics · Physics 2022-03-14 Giulio Del Corso , Roberto Verzicco , Francesco Viola

Human digital twin (HDT) is an emerging paradigm that bridges physical twins (PTs) with powerful virtual twins (VTs) for assisting complex task executions in human-centric services. In this paper, we study a two-timescale online…

Networking and Internet Architecture · Computer Science 2024-01-31 Yuye Yang , You Shi , Changyan Yi , Jun Cai , Jiawen Kang , Dusit Niyato , Xuemin , Shen

Digital Twin is an emerging technology that replicates real-world entities into a digital space. It has attracted increasing attention in the transportation field and many researchers are exploring its future applications in the development…

Robotics · Computer Science 2023-04-07 Zijin Wang , Ou Zheng , Liangding Li , Mohamed Abdel-Aty , Carolina Cruz-Neira , Zubayer Islam

We report a digital twin (DT) framework of electrical tomography (ET) to address the challenge of real-time quantitative multiphase flow imaging based on non-invasive and non-radioactive technologies. Multiphase flow is ubiquitous in…

Catheter ablation is currently the only curative treatment for scar-related ventricular tachycardias (VTs). However, not only are ablation procedures long, with relatively high risk, but success rates are punitively low, with frequent VT…

Digital twins (DTs), virtual simulated replicas of physical scenes, are transforming various industries. However, their potential in radio frequency (RF) sensing applications has been limited by the unidirectional nature of conventional RF…

Signal Processing · Electrical Eng. & Systems 2025-08-21 Xingyu Chen , Jianrong Ding , Kai Zheng , Xinmin Fang , Xinyu Zhang , Chris Xiaoxuan Lu , Zhengxiong Li

In Silico Clinical Trials (ISTC), i.e., clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce…

Artificial Intelligence · Computer Science 2021-06-22 Stefano Sinisi , Vadim Alimguzhin , Toni Mancini , Enrico Tronci , Federico Mari , Brigitte Leeners