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Supercomputers are complex, dynamic systems that serve thousands of users and are built with thousands of compute nodes. Due to the vast amounts of system and performance data needed to accurately capture their status, supercomputers…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-03-31 Elena Baskakova , William Bergeron , Matthew Hubbell , Hayden Jananthan , Jeremy Kepner

The growing importance of real-time simulation in the medical field has exposed the limitations and bottlenecks inherent in the digital representation of complex biological systems. This paper presents a novel methodology aimed at advancing…

Machine Learning · Computer Science 2024-12-17 Lucas Tesán , David González , Pedro Martins , Elías Cueto

Recently there has been a surge of interest in developing Digital Twins of process flows in healthcare to better understand bottlenecks and areas of improvement. A key challenge is in the validation process. We describe a work in progress…

Artificial Intelligence · Computer Science 2023-03-10 Muhammad Aurangzeb Ahmad , Vijay Chickarmane , Farinaz Sabz Ali Pour , Nima Shariari , Taposh Dutta Roy

Digital twin technology has a huge potential for widespread applications in different industrial sectors such as infrastructure, aerospace, and automotive. However, practical adoptions of this technology have been slower, mainly due to a…

Machine Learning · Statistics 2020-06-16 Souvik Chakraborty , Sondipon Adhikari

Objective: Modern medicine needs to shift from a wait and react, curative discipline to a preventative, interdisciplinary science aiming at providing personalised, systemic and precise treatment plans to patients. The aim of this work is to…

Machine Learning · Statistics 2020-09-18 Pietro Barbiero , Ramon Viñas Torné , Pietro Lió

Cognitive Twins (CT) are proposed as Digital Twins (DT) with augmented semantic capabilities for identifying the dynamics of virtual model evolution, promoting the understanding of interrelationships between virtual models and enhancing the…

Systems and Control · Electrical Eng. & Systems 2020-01-15 Jinzhi Lu , Xiaochen Zheng , Ali Gharaei , Kostas Kalaboukas , Dimitris Kiritsis

Recent technological advances have expanded the availability of high-throughput biological datasets, enabling the reliable design of digital twins of biomedical systems or patients. Such computational tools represent key reaction networks…

Quantitative Methods · Quantitative Biology 2025-09-03 Clémence Métayer , Annabelle Ballesta , Julien Martinelli

Numerical simulations can model the physical processes that govern cardiovascular device deployment. When such simulations incorporate digital twins; computational models of patient-specific anatomy, they can expedite and de-risk the device…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Karim Kadry , Shreya Gupta , Farhad R. Nezami , Elazer R. Edelman

Cardiovascular disease is the leading global cause of mortality, with coronary artery disease (CAD) as its most prevalent form, necessitating early risk prediction. While 3D coronary artery digital twins reconstructed from imaging offer…

A central problem in biomechanical studies of personalised human left ventricular (LV) modelling is estimating the material properties and biophysical parameters from in-vivo clinical measurements in a time frame suitable for use within a…

Applications · Statistics 2019-05-16 Vinny Davies , Umberto Noè , Alan Lazarus , Hao Gao , Benn Macdonald , Colin Berry , Xiaoyu Luo , Dirk Husmeier

The digital twin concept represents an appealing opportunity to advance condition-based and predictive maintenance paradigms for civil engineering systems, thus allowing reduced lifecycle costs, increased system safety, and increased system…

Numerical Analysis · Mathematics 2023-11-10 Matteo Torzoni , Marco Tezzele , Stefano Mariani , Andrea Manzoni , Karen E. Willcox

Ultrasound is well-established as an imaging modality for diagnostic and interventional purposes. However, the image quality varies with operator skills as acquiring and interpreting ultrasound images requires extensive training due to the…

The substantial computational cost of high-fidelity models in numerical hemodynamics has, so far, relegated their use mainly to offline treatment planning. New breakthroughs in data-driven architectures and optimization techniques for fast…

Current methodologies typically integrate biophysical brain models with functional magnetic resonance imaging(fMRI) data - while offering millimeter-scale spatial resolution (0.5-2 mm^3 voxels), these approaches suffer from limited temporal…

Neurons and Cognition · Quantitative Biology 2025-07-17 Yubo Hou , Zhengxin Zhang , Ziyi Wang , Wenlian Lu , Jianfeng Feng , Taiping Zeng

Virtual Imaging Trials (VIT) offer a cost-effective and scalable approach for evaluating medical imaging technologies. Computational phantoms, which mimic real patient anatomy and physiology, play a central role in VITs. However, the…

Digital Twins (DTs) are virtual representations of physical objects or processes that can collect information from the real environment to represent, validate, and replicate the physical twin's present and future behavior. The DTs are…

Networking and Internet Architecture · Computer Science 2023-05-26 S M Mostaq Hossain , Sohag Kumar Saha , Shampa Banik , Trapa Banik

Recently, significant efforts have been made to create Health Digital Twins (HDTs), digital twins for clinical applications. Heart modeling is one of the fastest-growing fields, which favors the effective application of HDTs. The clinical…

Neurons and Cognition · Quantitative Biology 2024-03-21 Zofia Rudnicka , Klaudia Proniewska , Mark Perkins , Agnieszka Pregowska

Different from traditional offline channel modeling, digital twin online channel modeling can sense and accurately characterize dynamic wireless channels in real time, and can therefore greatly assist 6G network optimization. This article…

Systems and Control · Electrical Eng. & Systems 2025-01-16 Junling Li , Cheng-Xiang Wang , Chen Huang , Tianrun Qi , Tong Wu

Electroanatomical mapping is a technique used in cardiology to create a detailed 3D map of the electrical activity in the heart. It is useful for diagnosis, treatment planning and real time guidance in cardiac ablation procedures to treat…

Image and Video Processing · Electrical Eng. & Systems 2023-11-29 Sunil Mathew , Jasbir Sra , Daniel B. Rowe

When they occur, azimuthal thermoacoustic oscillations can detrimentally affect the safe operation of gas turbines and aeroengines. We develop a real-time digital twin of azimuthal thermoacoustics of a hydrogen-based annular combustor. The…

Fluid Dynamics · Physics 2024-12-25 Andrea Nóvoa , Nicolas Noiray , James R. Dawson , Luca Magri
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