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Adhesion-independent migration is a prominent mode of cell motility in confined environments, yet the physical principles that guide such movement remain incompletely understood. We present a phase-field model for simulating the motility of…

Vascular networks exhibit a remarkable diversity of architectures and transport mechanisms across biological systems. Inspired by embolism propagation in plant xylem, where air invades water-filled conduits under negative pressure, we study…

Fluid Dynamics · Physics 2026-01-30 Ludovic Jami , François-Xavier Gauci , Céline Cohen , Xavier Noblin , Ludovic Keiser

Diffusive transport of small molecules within the internal structures of biological and synthetic material systems is complex because the crowded environment presents chemical and physical barriers to mobility. We explored this mobility…

Soft Condensed Matter · Physics 2020-09-29 Rajarshi Guha , Subhadip Ghosh , Darrell Velegol , Peter J. Butler , Ayusman Sen , Jennifer L. Ross

The cytoskeleton of eukaryotic cells provides mechanical support and governs intracellular transport. These functions rely on the complex mechanical properties of networks of semiflexible protein filaments. Recent theoretical interest has…

Soft Condensed Matter · Physics 2012-11-01 M. Atakhorrami , G. H. Koenderink , J. F. Palierne , F. C. MacKintosh , C. F. Schmidt

Slime mould of Physarum polycephalum is a large cell exhibiting rich spatial non-linear electrical characteristics. We exploit the electrical properties of the slime mould to implement logic gates using a flexible hardware platform designed…

Emerging Technologies · Computer Science 2016-07-11 Simon Harding , Jan Koutnik , Klaus Greff , Jurgen Schmidhuber , Andy Adamatzky

Slime mould plasmodia can adjust their behaviour in response to chemical trails left by themselves and other Physarum plasmodia. This simple feedback process increases their foraging efficiency. We still do not know whether other factors…

Populations and Evolution · Quantitative Biology 2019-05-17 Eilidh Stirrup , David Lusseau

Slime mould Physarum polycephalum is a large single cell visible by unaided eye. We design a slime mould implementation of a tactile hair, where the slime mould responds to repeated deflection of hair by an immediate high-amplitude spike…

Emerging Technologies · Computer Science 2013-06-13 Andrew Adamatzky

How do the topology and geometry of a tubular network affect the spread of particles within fluid flows? We investigate patterns of effective dispersion in the hierarchical, biological transport network formed by Physarum polycephalum. We…

Biological Physics · Physics 2016-11-28 Sophie Marbach , Karen Alim , Natalie Andrew , Anne Pringle , Michael P. Brenner

Cells control the size and organization of biomolecular condensates formed by liquid-liquid phase separation (LLPS), but multiple mechanisms likely contribute to this control and remain to be fully elucidated. Here we propose a…

Biological Physics · Physics 2026-04-10 Le Qiao , Peter Gispert , Lukas S. Stelzl , Friederike Schmid

Living cells move thanks to assemblies of actin filaments and myosin motors that range from very organized striated muscle tissue to disordered intracellular bundles. The mechanisms powering these disordered structures are debated, and all…

Biological Physics · Physics 2017-09-26 Martin Lenz

In recent years the functionality of synthetic active microparticles has edged even closer to that of their biological counterparts. However, we still lack the understanding needed to recreate at the microscale key features of autonomous…

Soft Condensed Matter · Physics 2024-10-28 Philipp W. A. Schönhöfer , Sharon C. Glotzer

Transport networks are crucial for the functioning of natural and technological systems. We study a mathematical model of vascular network adaptation, where the network structure dynamically adjusts to changes in blood flow and pressure.…

Adaptation and Self-Organizing Systems · Physics 2023-06-01 Konstantin Klemm , Erik Andreas Martens

Slime mould \emph{Physarum polycephalum} is a large single cell capable for distributed sensing, concurrent information processing, parallel computation and decentralised actuation. The ease of culturing and experimenting with Physarum…

Emerging Technologies · Computer Science 2015-12-29 Andrew Adamatzky

The investigation of collective behaviour in dense assemblies of self-propelled active particles has been motivated by a wide range of biological phenomena. Of particular interest are dynamical transitions of cellular and sub-cellular…

Soft Condensed Matter · Physics 2023-12-05 Yagyik Goswami , G. V. Shivashankar , Srikanth Sastry

We study the mobilization of an oil droplet in a deformable, actuated constricted tube subjected to two different actuation mechanisms: hydrodynamic actuation (oscillatory body force in the fluid) and dynamic wall actuation (oscillatory…

Fluid Dynamics · Physics 2026-03-26 Sthavishtha R. Bhopalam , Ruben Juanes , Hector Gomez

Biological locomotion in nature is often achieved by the interaction between a flexible body and its surrounding medium. The interaction of a flexible body with granular media is less understood compared with viscous fluids partially due to…

Fluid Dynamics · Physics 2017-08-03 Zhiwei Peng , Yang Ding , Kyle Pietrzyk , Gwynn J. Elfring , On Shun Pak

We study transport in synthetic, bi-disperse porous structures, with arrays of microchannels interconnected by a nanoporous layer. These structures are inspired by the xylem tissue in vascular plants, in which sap water travels from the…

Soft Condensed Matter · Physics 2024-07-23 Olivier Vincent , Théo Tassin , Erik J. Huber , Abraham D. Stroock

Many active fluid systems encountered in biology are set in total geometric confinement. Cytoplasmic streaming in plant cells is a prominent and ubiquitous example, in which cargo-carrying molecular motors move along polymer filaments and…

Soft Condensed Matter · Physics 2013-01-10 Francis G. Woodhouse , Raymond E. Goldstein

Plasmodium of \emph{Physarum polycephalum} is a single huge (visible by naked eye) cell with myriad of nuclei. The plasmodium is a promising substrate for non-classical, nature-inspired, computing devices. It is capable for approximation of…

Robotics · Computer Science 2010-11-23 Andrew Adamatzky

We experimentally, numerically and analytically explore the diffusive transport of active colloidal particles with sensory delay, navigating motility landscapes in which the self-propulsion speed depends on space. We show how the transport…

Statistical Mechanics · Physics 2026-04-29 Adrià Garcés , Ueli Töpfer , Lucio Isa , Demian Levis , Ignacio Pagonabarraga
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