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Protein fitness optimization is inherently a discrete combinatorial problem, yet most learning-based approaches rely on continuous representations and are primarily evaluated through predictive accuracy. We introduce Q-BIOLAT, a framework…

Machine Learning · Computer Science 2026-03-31 Truong-Son Hy

Many computationally hard problems can be encoded in quantum Hamiltonians. The solution to these problems is given by the ground states of these Hamiltonians. A state-of-the-art algorithm for finding the ground state of a Hamiltonian is the…

Imaginary Time Evolution (QITE) approximates this evolution on quantum hardware but suffers from high circuit depth and numerous measurements. In this work we introduce Adaptive-time Compressed QITE (ACQ), a novel algorithm that reduces…

Quadratic unconstrained binary optimization (QUBO) has become the standard format for optimization using quantum computers, i.e., for both the quantum approximate optimization algorithm (QAOA) and quantum annealing (QA). We present a…

Quantum Physics · Physics 2022-04-26 Thomas Gabor , Marian Lingsch Rosenfeld , Sebastian Feld , Claudia Linnhoff-Popien

Variational Quantum optimization algorithms, such as the Variational Quantum Eigensolver (VQE) or the Quantum Approximate Optimization Algorithm (QAOA), are among the most studied quantum algorithms. In our work, we evaluate and improve an…

Quantum Physics · Physics 2022-10-24 David Winderl , Nicola Franco , Jeanette Miriam Lorenz

Quantum optimization methods use a continuous degree-of-freedom of quantum states to heuristically solve combinatorial problems, such as the MAX-CUT problem, which can be attributed to various NP-hard combinatorial problems. This paper…

Quantum Physics · Physics 2025-01-15 Ruho Kondo , Yuki Sato , Rudy Raymond , Naoki Yamamoto

A probabilistic imaginary-time evolution (PITE) method was proposed as a nonvariational method to obtain a ground state on a quantum computer. In this formalism, the success probability of obtaining all imaginary-time evolution operators…

Quantum Physics · Physics 2022-12-29 Hirofumi Nishi , Taichi Kosugi , Yusuke Nishiya , Yu-ichiro Matsushita

We give a quantum algorithm to exactly solve certain problems in combinatorial optimization, including weighted MAX-2-SAT as well as problems where the objective function is a weighted sum of products of Ising variables, all terms of the…

Quantum Physics · Physics 2018-07-20 M. B. Hastings

We introduce SamBa-GQW, a novel quantum algorithm for solving binary combinatorial optimization problems of arbitrary degree with no use of any classical optimizer. The algorithm is based on a continuous-time quantum walk on the solution…

Quantum Physics · Physics 2025-09-19 Ugo Nzongani , Dylan Laplace Mermoud , Giuseppe Di Molfetta , Andrea Simonetto

In this note, we describe an experiment on portfolio optimization using the Quadratic Unconstrained Binary Optimization (QUBO) formulation. The dataset we use is taken from a real-world problem for which a classical solution is currently…

This paper introduces a non-variational quantum algorithm designed to solve a wide range of combinatorial optimisation problems, including constrained and non-binary problems. The algorithm leverages an engineered interference process…

Quantum Physics · Physics 2024-08-02 Tavis Bennett , Lyle Noakes , Jingbo Wang

Computing the partition function $Z$ of a discrete graphical model is a fundamental inference challenge. Since this is computationally intractable, variational approximations are often used in practice. Recently, so-called gauge…

Machine Learning · Statistics 2018-03-06 Sungsoo Ahn , Michael Chertkov , Jinwoo Shin , Adrian Weller

Quadratic Unconstrained Binary Optimization (QUBO) is a standard NP-hard optimization problem. Recently, it has gained renewed interest through quantum computing, as QUBOs directly reduce to the Ising model, on which quantum annealing…

Quantum Physics · Physics 2026-03-16 Katalin Friedl , Levente Gegő , László Kabódi , Viktória Nemkin

Quadratic Unconstrained Binary Optimization (QUBO) sits at the heart of many industries and academic fields such as logistics, supply chain, finance, pharmaceutical science, chemistry, IT, and energy sectors, among others. These problems…

Quantum Physics · Physics 2025-12-02 Chia-Tso Lai , Carsten Blank , Peter Schmelcher , Rick Mukherjee

We propose and evaluate a quantum-inspired algorithm for solving Quadratic Unconstrained Binary Optimization (QUBO) problems, which are mathematically equivalent to finding ground states of Ising spin-glass Hamiltonians. The algorithm…

Artificial Intelligence · Computer Science 2025-10-24 Max B. Zhao , Fei Li

We aim to advance the state-of-the-art in Quadratic Unconstrained Binary Optimization formulation with a focus on cryptography algorithms. As the minimal QUBO encoding of the linear constraints of optimization problems emerges as the…

Cryptography and Security · Computer Science 2026-04-16 Gregory Morse , Tamás Kozsik , Oskar Mencer , Peter Rakyta

Diagnosing the minimal set of faults capable of explaining a set of given observations, e.g., from sensor readouts, is a hard combinatorial optimization problem usually tackled with artificial intelligence techniques. We present the mapping…

A major challenge in machine learning is the computational expense of training these models. Model training can be viewed as a form of optimization used to fit a machine learning model to a set of data, which can take up significant amount…

Machine Learning · Computer Science 2021-11-16 Prasanna Date , Thomas Potok

Pauli Correlation Encoding (PCE) is as a qubit-efficient variational approach to combinatorial optimization problems. The method offers a polynomial reduction in qubit count and a super-polynomial suppression of barren plateaus. Here, we…

Variational Quantum Algorithms (VQAs) provide a promising framework for tackling complex optimization problems on near-term quantum hardware. Here, we demonstrate that hybrid qubit--qumode quantum devices offer an efficient route to solving…

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