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A general framework to describe a vast majority of biology-inspired systems is to model them as stochastic processes in which multiple couplings are in play at the same time. Molecular motors, chemical reaction networks, catalytic enzymes,…

Statistical Mechanics · Physics 2020-11-25 Daniel M. Busiello , Deepak Gupta , Amos Maritan

The classical theory of chemical reactions can be understood in terms of diffusive barrier crossing, where the rate of a reaction is determined by the inverse of the mean first passage time (FPT) to cross a free energy barrier. Whenever a…

Statistical Mechanics · Physics 2019-11-22 David Hartich , Aljaz Godec

Autocatalytic processes underlie diverse systems in which replication is triggered at interfaces, including heterogeneous catalysis on solid substrates, enzyme activity at membranes, viral infections, biofilm growth, and spatially…

Chemical Physics · Physics 2026-04-24 Denis S. Grebenkov

We have a general knowledge of the principles by which catalysts accelerate the rate of chemical reactions but no precise understanding of the geometrical and physical constraints to which their design is subject. To analyze these…

Biomolecules · Quantitative Biology 2019-11-11 Olivier Rivoire

This chapter presents, from a quantum-mechanical point of view, a tutorial discussion of elementary collision processes in the bulk of a gas discharge. Instead of merely listing kitchen-made cross section formulae and unrelated cross…

Plasma Physics · Physics 2008-10-14 Franz X. Bronold , H. Fehske

Many biological molecular motors and machines are driven by chemical reactions that occur in specific catalytic sites. We study whether the arrival of molecules to such an active site can be accelerated by the presence of a nearby inactive…

Statistical Mechanics · Physics 2025-01-06 Hila Katznelson , Saar Rahav

Explaining the origin of life requires us to explain how self-replication arises. To be specific, how can a self-replicating entity develop spontaneously from a chemical reaction system in which no reaction is self-replicating? Previously…

Adaptation and Self-Organizing Systems · Physics 2020-12-18 Yu Liu , David Sumpter

Kinetics of the first order phase transition has been investigated. The case when the droplets sizes have a limit value is considered. An analytical theory for such process has been constructed and all main characteristics of the process…

Statistical Mechanics · Physics 2007-05-23 V. Kurasov

This paper develops some basic principles to study autocatalytic networks and exploit their structural properties in order to characterize their inherent fundamental limits and tradeoffs. In a dynamical system with autocatalytic structure,…

Systems and Control · Computer Science 2017-06-30 Milad Siami , Nader Motee , Gentian Buzi , Bassam Bamieh , Mustafa Khammash , John C. Doyle

We investigate the catalytic reactions model used in cell modeling. The reaction kinetic is defined through the energies of different species of molecules following random independent distribution. The related statistical physics model has…

Other Quantitative Biology · Quantitative Biology 2015-06-12 David B. Saakian , Laurent Schwartz

Classical theories of chemical kinetics assume independent reactions in dilute solutions, whose rates are determined by mean concentrations. In condensed matter, strong interactions alter chemical activities and create inhomogeneities that…

Materials Science · Physics 2013-04-17 Martin Z. Bazant

A theory of aging based on the principles of the kinetics of chemical reactions and the rules of natural selection of organisms is proposed. The theory is based on a hypothesis that the biochemical processes in the organism can be described…

Populations and Evolution · Quantitative Biology 2024-01-09 Alexey Kondyurin

Protein function often involves changes between different conformations. Central questions are how these conformational changes are coupled to the binding or catalytic processes during which they occur, and how they affect the catalytic…

Biomolecules · Quantitative Biology 2012-05-11 Thomas R. Weikl , David D. Boehr

Thermal operations are a generic description for allowed state transitions under thermodynamic restrictions. However, the quest for simpler methods to encompass all these processes remains unfulfilled. We resolve this challenge through the…

Quantum Physics · Physics 2024-10-16 Jeongrak Son , Nelly H. Y. Ng

A stochastic model for the dynamics of enzymatic catalysis in explicit, effective solvents under physiological conditions is presented. Analytically-computed first passage time densities of a diffusing particle in a spherical shell with…

Biomolecules · Quantitative Biology 2015-06-04 Jeremy Schofield , Paul Inder , Raymond Kapral

Non-ideal deterministic system "tank with liquid-electric motor" is studied. Two delay-approximation models are considered. Impact of the delay on the emergence, evolution and disappearance of regular and chaotic limit sets (attractors) of…

Chaotic Dynamics · Physics 2025-12-16 I. A. Seit-Dzhelil , A. Yu. Shvets

Phase transitions, such as the freezing of water and the magnetisation of a ferromagnet upon lowering the ambient temperature, are familiar physical phenomena. Interestingly, such a collective change of behaviour at a phase transition is…

Biological Physics · Physics 2018-10-26 Chiu Fan Lee , Jean David Wurtz

Motor enzymes are remarkable molecular machines that use the energy derived from the hydrolysis of a nucleoside triphosphate to generate mechanical movement, achieved through different steps that constitute their kinetic cycle. These…

Subcellular Processes · Quantitative Biology 2014-09-05 Luca Ciandrini , M. Carmen Romano , A. Parmeggiani

We introduce a simple model of heterogeneous catalysis on a disordered surface which consists of two types of randomly distributed sites with different adsorption rates. Disorder can create a reactive steady state in situations where the…

Condensed Matter · Physics 2009-10-28 L. Frachebourg , P. L. Krapivsky , S. Redner

We demonstrate that autocatalytic reactions, where a product catalyzes its own formation, can be significantly accelerated when the product molecules are indistinguishable from each other. This ``combinatorial enhancement," analogous to the…

Statistical Mechanics · Physics 2025-03-19 Nanako Hirano , Akira Yoshida , Takenobu Nakamura , Naoko Nakagawa