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We present an experimental realization of a 16 element, temporal-array, photon-number-resolving (PNR) detector, which is a multiplexed single-photon detector that splits an input signal over multiple time-bins, and the time-bins are…
Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to…
Single-beam scanning microscopy (SBSM) is one of the most robust strategies for commercial optical systems. Although structured illumination combined with Fourier-domain spatial spectrum fusion can enhance SBSM resolution beyond the…
Superconducting nanowire single-photon detectors (SNSPDs) have been widely used to study the discrete nature of quantum states of light in the form of photon-counting experiments. We show that SNSPDs can also be used to study continuous…
Convolutional neural networks (CNNs) have gained tremendous success in solving complex inverse problems. The aim of this work is to develop a novel CNN framework to reconstruct video sequence of dynamic live cells captured using a…
Localized surface plasmons can confine light within a deep-subwavelength volume comparable to the scale of atoms and molecules, enabling ultrasensitive responses to near-field variations. On the other hand, this extreme localization also…
The spectral detection efficiency and the dark count rate of superconducting nanowire single-photon detectors (SNSPD) has been studied systematically on detectors made from thin NbN films with different chemical compositions. Reduction of…
We developed superconducting nanowire single-photon detectors with an optical cavity (OC-SNSPDs) for multichannel systems. For efficient coupling, the devices were installed in compact fiber-coupled packages after their substrate thickness…
Lensless digital holographic microscopy (LDHM) relies on interference between an unscattered reference wave and a weakly scattered object wave - an assumption that rapidly fails in turbid samples under multiple scattering. To overcome this…
In this paper we briefly review the state-of-the-art of intrinsic photon-number resolution (PNR) with superconducting nanowire single-photon detectors (SNSPDs) and will provide an overview of the various experimental techniques employed to…
Mid-infrared photothermal microscopy is a new chemical imaging technology in which a visible beam senses the photothermal effect induced by a pulsed infrared laser. This technology provides infrared spectroscopic information at sub-micron…
Near-infrared (NIR) hyperspectral imaging is widely used to reveal morphological and chemical information. However, conventional spectral imagers usually rely on costly focal plane arrays and suffer from data redundancy and inefficiencies…
Current crowding at bends of superconducting nanowire single-photon detectors is one of the main factors limiting the performance of meander-style detectors with large filling factors. In this paper, we propose a new concept to reduce…
A superconducting thin film with uniform properties is the key to realize nanowire superconducting single-photon detectors (SSPDs) with high performance and high yield. To investigate the uniformity of NbN films, we introduce and…
A superconducting nanowire single photon detector (SNSPD) system for telecommunication wavelength using a GM cryocooler was developed and its performance was verified. The cryocooler based SNSPD system can operate continuously with a 100 V…
Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an…
Magnetic resonance imaging (MRI) has revolutionized biomedical science by providing non-invasive, three-dimensional biological imaging. However, spatial resolution in conventional MRI systems is limited to tens of microns, which is…
Fourier ptychographic microscopy (FPM) is a powerful computational imaging modality that achieves high space-bandwidth product imaging for biomedical samples. However, its adoption is limited by slow data acquisition due to the need for…
Confocal and multi-photon microscopy are widely used for in-vivo fluorescence imaging of biological tissues such as the brain, offering non-invasive access up to ~1 mm depth without major loss in performance. A recently-developed…
Future astrophysics and cosmic microwave background space missions operating in the far-infrared to millimetre part of the spectrum will require very large arrays of ultra-sensitive detectors in combination with high multiplexing factors…