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While neural networks have been successfully applied to many natural language processing tasks, they come at the cost of interpretability. In this paper, we propose a general methodology to analyze and interpret decisions from a neural…

Computation and Language · Computer Science 2017-01-11 Jiwei Li , Will Monroe , Dan Jurafsky

Pretrained language models (LMs) encode implicit representations of knowledge in their parameters. However, localizing these representations and disentangling them from each other remains an open problem. In this work, we investigate…

Computation and Language · Computer Science 2024-10-16 Deniz Bayazit , Negar Foroutan , Zeming Chen , Gail Weiss , Antoine Bosselut

Protein language models (PLMs) learn contextual representations from protein sequences and are profoundly impacting various scientific disciplines spanning protein design, drug discovery, and structural predictions. One particular research…

Quantitative Methods · Quantitative Biology 2024-02-07 Andreas Dounas , Tudor-Stefan Cotet , Alexander Yermanos

Neural language models (LMs) have been extensively trained on vast corpora to store factual knowledge about various aspects of the world described in texts. Current technologies typically employ knowledge editing methods or specific prompts…

Computation and Language · Computer Science 2024-05-14 Yuchen Cai , Ding Cao , Rongxi Guo , Yaqin Wen , Guiquan Liu , Enhong Chen

KEPLMs are pre-trained models that utilize external knowledge to enhance language understanding. Previous language models facilitated knowledge acquisition by incorporating knowledge-related pre-training tasks learned from relation triples…

Computation and Language · Computer Science 2024-03-19 Junbing Yan , Chengyu Wang , Taolin Zhang , Xiaofeng He , Jun Huang , Longtao Huang , Hui Xue , Wei Zhang

Numerous cellular functions rely on protein$\unicode{x2013}$protein interactions. Efforts to comprehensively characterize them remain challenged however by the diversity of molecular recognition mechanisms employed within the proteome. Deep…

Biomolecules · Quantitative Biology 2023-12-08 Julia R. Rogers , Gergő Nikolényi , Mohammed AlQuraishi

Entities, as important carriers of real-world knowledge, play a key role in many NLP tasks. We focus on incorporating entity knowledge into an encoder-decoder framework for informative text generation. Existing approaches tried to index,…

Computation and Language · Computer Science 2023-04-25 Zhihan Zhang , Wenhao Yu , Chenguang Zhu , Meng Jiang

Large language models (LLMs) have demonstrated dominating performance in many NLP tasks, especially on generative tasks. However, they often fall short in some information extraction tasks, particularly those requiring domain-specific…

Computation and Language · Computer Science 2023-09-22 Junyi Bian , Jiaxuan Zheng , Yuyi Zhang , Shanfeng Zhu

Neural network interpretability is a vital component for applications across a wide variety of domains. In such cases it is often useful to analyze a network which has already been trained for its specific purpose. In this work, we develop…

Machine Learning · Computer Science 2019-11-19 Lawrence Phillips , Garrett Goh , Nathan Hodas

Exponential growth in Electronic Healthcare Records (EHR) has resulted in new opportunities and urgent needs for discovery of meaningful data-driven representations and patterns of diseases in Computational Phenotyping research. Deep…

Machine Learning · Statistics 2015-12-14 Zhengping Che , Sanjay Purushotham , Robinder Khemani , Yan Liu

Inferring the structural properties of a protein from its amino acid sequence is a challenging yet important problem in biology. Structures are not known for the vast majority of protein sequences, but structure is critical for…

Machine Learning · Computer Science 2019-10-17 Tristan Bepler , Bonnie Berger

For natural language understanding tasks, either machine reading comprehension or natural language inference, both semantics-aware and inference are favorable features of the concerned modeling for better understanding performance. Thus we…

Computation and Language · Computer Science 2020-04-29 Shuailiang Zhang , Hai Zhao , Junru Zhou

Despite the remarkable evolution of deep neural networks in natural language processing (NLP), their interpretability remains a challenge. Previous work largely focused on what these models learn at the representation level. We break this…

Computation and Language · Computer Science 2018-12-27 Fahim Dalvi , Nadir Durrani , Hassan Sajjad , Yonatan Belinkov , Anthony Bau , James Glass

The predictive power of neural networks often costs model interpretability. Several techniques have been developed for explaining model outputs in terms of input features; however, it is difficult to translate such interpretations into…

Machine Learning · Computer Science 2017-08-17 Benjamin J. Lengerich , Sandeep Konam , Eric P. Xing , Stephanie Rosenthal , Manuela Veloso

The proliferation of deep neural networks in various domains has seen an increased need for interpretability of these models. Preliminary work done along this line and papers that surveyed such, are focused on high-level representation…

Computation and Language · Computer Science 2022-08-17 Hassan Sajjad , Nadir Durrani , Fahim Dalvi

Large Language Models (LLMs) have revolutionized the field of natural language processing, but they fall short in comprehending biological sequences such as proteins. To address this challenge, we propose InstructProtein, an innovative LLM…

Biomolecules · Quantitative Biology 2023-10-06 Zeyuan Wang , Qiang Zhang , Keyan Ding , Ming Qin , Xiang Zhuang , Xiaotong Li , Huajun Chen

Machine learning is capable of discriminating phases of matter, and finding associated phase transitions, directly from large data sets of raw state configurations. In the context of condensed matter physics, most progress in the field of…

Statistical Mechanics · Physics 2017-12-06 Pedro Ponte , Roger G. Melko

Multilingual neural machine translation with a single model has drawn much attention due to its capability to deal with multiple languages. However, the current multilingual translation paradigm often makes the model tend to preserve the…

Computation and Language · Computer Science 2021-07-15 Wanying Xie , Yang Feng , Shuhao Gu , Dong Yu

Protein language models (PLMs) learn probability distributions over natural protein sequences. By learning from hundreds of millions of natural protein sequences, protein understanding and design capabilities emerge. Recent works have shown…

Quantitative Methods · Quantitative Biology 2026-02-27 Timothy Fei Truong , Tristan Bepler

Learning word representations has recently seen much success in computational linguistics. However, assuming sequences of word tokens as input to linguistic analysis is often unjustified. For many languages word segmentation is a…

Computation and Language · Computer Science 2013-09-19 Grzegorz Chrupała