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Protein language models are a powerful tool for learning protein representations through pre-training on vast protein sequence datasets. However, traditional protein language models lack explicit structural supervision, despite its…

Biomolecules · Quantitative Biology 2024-02-09 Zuobai Zhang , Jiarui Lu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

The application of deep learning methods, particularly foundation models, in biological research has surged in recent years. These models can be text-based or trained on underlying biological data, especially omics data of various types.…

Artificial Intelligence · Computer Science 2024-12-06 Yoav Kan-Tor , Michael Morris Danziger , Eden Zohar , Matan Ninio , Yishai Shimoni

Discovery gene-disease links is important in biology and medicine areas, enabling disease identification and drug repurposing. Machine learning approaches accelerate this process by leveraging biological knowledge represented in ontologies…

Machine Learning · Computer Science 2025-04-14 Catarina Canastra , Cátia Pesquita

With the recent proliferation of large language models (LLMs), such as Generative Pre-trained Transformers (GPT), there has been a significant shift in exploring human and machine comprehension of semantic language meaning. This shift calls…

Computation and Language · Computer Science 2023-10-18 Yuhong Zhang , Qin Li , Sujal Nahata , Tasnia Jamal , Shih-kuen Cheng , Gert Cauwenberghs , Tzyy-Ping Jung

Large Language Models (LLMs) have been increasingly studied as neural knowledge bases for supporting knowledge-intensive applications such as question answering and fact checking. However, the structural organization of their knowledge…

Machine Learning · Computer Science 2026-01-16 Utkarsh Sahu , Zhisheng Qi , Mahantesh Halappanavar , Nedim Lipka , Ryan A. Rossi , Franck Dernoncourt , Yu Zhang , Yao Ma , Yu Wang

Bayesian models of cognition hypothesize that human brains make sense of data by representing probability distributions and applying Bayes' rule to find the best explanation for available data. Understanding the neural mechanisms underlying…

Neural and Evolutionary Computing · Computer Science 2021-07-02 Milad Kharratzadeh , Thomas R. Shultz

Recursive neural networks (RvNN) have been shown useful for learning sentence representations and helped achieve competitive performance on several natural language inference tasks. However, recent RvNN-based models fail to learn simple…

Computation and Language · Computer Science 2021-04-13 Atul Sahay , Ayush Maheshwari , Ritesh Kumar , Ganesh Ramakrishnan , Manjesh Kumar Hanawal , Kavi Arya

Text representations using neural word embeddings have proven effective in many NLP applications. Recent researches adapt the traditional word embedding models to learn vectors of multiword expressions (concepts/entities). However, these…

Computation and Language · Computer Science 2018-12-21 Walid Shalaby , Wlodek Zadrozny , Hongxia Jin

It is very useful to integrate human knowledge and experience into traditional neural networks for faster learning speed, fewer training samples and better interpretability. However, due to the obscured and indescribable black box model of…

Machine Learning · Computer Science 2018-10-02 Guangming Shi , Zhongqiang Zhang , Dahua Gao , Xuemei Xie , Yihao Feng , Xinrui Ma , Danhua Liu

In large language models (LLMs), certain \emph{neurons} can store distinct pieces of knowledge learned during pretraining. While factual knowledge typically appears as a combination of \emph{relations} and \emph{entities}, it remains…

My doctoral research focuses on understanding semantic knowledge in neural network models trained solely to predict natural language (referred to as language models, or LMs), by drawing on insights from the study of concepts and categories…

Computation and Language · Computer Science 2021-11-05 Kanishka Misra

Proteins play a vital role in biological processes and are indispensable for living organisms. Accurate representation of proteins is crucial, especially in drug development. Recently, there has been a notable increase in interest in…

Biomolecules · Quantitative Biology 2026-05-28 Dan Kalifa , Uriel Singer , Kira Radinsky

Language models' (LMs) proficiency in handling deterministic symbolic reasoning and rule-based tasks remains limited due to their dependency implicit learning on textual data. To endow LMs with genuine rule comprehension abilities, we…

Computation and Language · Computer Science 2024-03-12 Yixuan Weng , Minjun Zhu , Fei Xia , Bin Li , Shizhu He , Kang Liu , Jun Zhao

In recent years, substantial advancements have been made in the development of large language models, achieving remarkable performance across diverse tasks. To evaluate the knowledge ability of language models, previous studies have…

Computation and Language · Computer Science 2024-05-30 Xunjian Yin , Xu Zhang , Jie Ruan , Xiaojun Wan

The goal of text generation is to make machines express in human language. It is one of the most important yet challenging tasks in natural language processing (NLP). Since 2014, various neural encoder-decoder models pioneered by Seq2Seq…

Computation and Language · Computer Science 2022-01-25 Wenhao Yu , Chenguang Zhu , Zaitang Li , Zhiting Hu , Qingyun Wang , Heng Ji , Meng Jiang

Neural networks are becoming a popular tool for solving many real-world problems such as object recognition and machine translation, thanks to its exceptional performance as an end-to-end solution. However, neural networks are complex…

Machine Learning · Computer Science 2020-09-29 Guoliang Dong , Jingyi Wang , Jun Sun , Yang Zhang , Xinyu Wang , Ting Dai , Jin Song Dong , Xingen Wang

Knowledge-enhanced neural machine reasoning has garnered significant attention as a cutting-edge yet challenging research area with numerous practical applications. Over the past few years, plenty of studies have leveraged various forms of…

Artificial Intelligence · Computer Science 2023-02-08 Tanmoy Chowdhury , Chen Ling , Xuchao Zhang , Xujiang Zhao , Guangji Bai , Jian Pei , Haifeng Chen , Liang Zhao

Interpretability and explainability of neural networks is continuously increasing in importance, especially within safety-critical domains and to provide the social right to explanation. Concept based explanations align well with how humans…

Machine Learning · Computer Science 2023-09-11 Rishabh Jain

Background: Identification of the interactions and regulatory relations between biomolecules play pivotal roles in understanding complex biological systems and the mechanisms underlying diverse biological functions. However, the collection…

Computation and Language · Computer Science 2025-04-24 Gilchan Park , Byung-Jun Yoon , Xihaier Luo , Vanessa López-Marrero , Shinjae Yoo , Shantenu Jha

Deep Learning and Machine Learning based models have become extremely popular in text processing and information retrieval. However, the non-linear structures present inside the networks make these models largely inscrutable. A significant…

Information Retrieval · Computer Science 2026-03-12 Sourav Saha , Debapriyo Majumdar , Mandar Mitra
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