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Generative models hold great promise for accelerating materials discovery, but their evaluation often overlooks the chemical validity and stability requirements crucial to real-world applications. Density Functional Theory (DFT) simulations…

Materials Science · Physics 2026-01-06 Elohan Veillon , Astrid Klipfel , Adlane Sayede , Zied Bouraoui

One of the main goals and challenges of materials discovery is to find the best candidates for each interest property or application. Machine learning rises in this context to efficiently optimize this search, exploring the immense…

Materials Science · Physics 2021-08-04 Gabriel R. Schleder , Bruno Focassio , Adalberto Fazzio

Despite recent advances, goal-directed generation of structured discrete data remains challenging. For problems such as program synthesis (generating source code) and materials design (generating molecules), finding examples which satisfy…

Machine Learning · Computer Science 2020-10-26 Amina Mollaysa , Brooks Paige , Alexandros Kalousis

We report a deep learning (DL) framework viz. deep autoencoder that autonomously discovers an appropriate order parameter from molecular dynamics (MD) simulation data to characterize the coil to globule phase transition of a polymer. The…

Materials Science · Physics 2021-02-25 Debjyoti Bhattacharya , Tarak K Patra

With the growing availability of data within various scientific domains, generative models hold enormous potential to accelerate scientific discovery. They harness powerful representations learned from datasets to speed up the formulation…

The functionality of catalysts, enzymes, and supramolecular assemblies emerges not from individual molecules alone, but from the subtle interplay between multiple components arranged in complex systems. Designing such systems is a grand…

Computational Physics · Physics 2026-04-15 Rhyan Barrett , Robin Curth , Julia Westermayr

Modern data-driven tools are transforming application-specific polymer development cycles. Surrogate models that can be trained to predict the properties of new polymers are becoming commonplace. Nevertheless, these models do not utilize…

The goal of structure-based drug discovery is to find small molecules that bind to a given target protein. Deep learning has been used to generate drug-like molecules with certain cheminformatic properties, but has not yet been applied to…

Quantitative Methods · Quantitative Biology 2022-01-27 Matthew Ragoza , Tomohide Masuda , David Ryan Koes

The use of machine learning algorithms is an attractive way to produce very fast detector simulations for scattering reactions that can otherwise be computationally expensive. Here we develop a factorised approach where we deal with each…

Data Analysis, Statistics and Probability · Physics 2022-07-26 D. Darulis , R. Tyson , D. G. Ireland , D. I. Glazier , B. McKinnon , P. Pauli

Polymers are a versatile class of materials with widespread industrial applications. Advanced computational tools could revolutionize their design, but their complex, multi-scale nature poses significant modeling challenges. Conventional…

In this paper, we propose a novel transfer learning approach called multi-modal cascade model with feature transfer for polymer property prediction.Polymers are characterized by a composite of data in several different formats, including…

Machine Learning · Statistics 2025-05-08 Kiichi Obuchi , Yuta Yahagi , Kiyohiko Toyama , Shukichi Tanaka , Kota Matsui

Engineering new glass compositions have experienced a sturdy tendency to move forward from (educated) trial-and-error to data- and simulation-driven strategies. In this work, we developed a computer program that combines data-driven…

Materials Science · Physics 2021-03-17 Daniel R. Cassar , Gisele G. dos Santos , Edgar D. Zanotto

Poly(ethylene terephthalate) (PET), a widely used thermoplastic in packaging, textiles, and engineering applications, is valued for its strength, clarity, and chemical resistance. Increasing environmental impact concerns and regulatory…

Soft Condensed Matter · Physics 2025-11-10 Chiho Kim , Wei Xiong , Akhlak Mahmood , Rampi Ramprasad , Huan Tran

Discovering materials with new structural chemistry is key to achieving transformative functionality. Generative artificial intelligence offers a scalable route to propose candidate crystal structures. We introduce a reliable low-cost proxy…

Ionizable lipids are essential in developing lipid nanoparticles (LNPs) for effective messenger RNA (mRNA) delivery. While traditional methods for designing new ionizable lipids are typically time-consuming, deep generative models have…

Machine Learning · Computer Science 2024-12-03 Jingyi Zhao , Yuxuan Ou , Austin Tripp , Morteza Rasoulianboroujeni , José Miguel Hernández-Lobato

A versatile and transferable coarse-grained (CG) model was developed to investigate the self-assembly of two ubiquitous methacrylate-based copolymers: poly(ethylene oxide-b-methylmethacrylate) (PEO-b-PMMA) and poly(ethylene…

Soft Condensed Matter · Physics 2018-05-29 Gerardo Campos-Villalobos , Flor R. Siperstein , Alessandro Patti

Computing atomic-scale properties of chemically disordered materials requires an efficient exploration of their vast configuration space. Traditional approaches such as Monte Carlo or Special Quasirandom Structures either entail sampling an…

Materials Science · Physics 2026-03-17 Maciej J. Karcz , Luca Messina , Eiji Kawasaki , Emeric Bourasseau

Over the past decade or two, the concept has emerged of using multiple types of weak interactions simultaneously to enhance the mechanical properties of elastomers. These weak interactions include physical entanglements, hydrogen bonds,…

Soft Condensed Matter · Physics 2022-11-14 Zhongtong Wang , Hongyi Cai , Meredith N. Silberstein

In recent years, promising deep learning based interatomic potential energy surface (PES) models have been proposed that can potentially allow us to perform molecular dynamics simulations for large scale systems with quantum accuracy.…

Computational Physics · Physics 2020-06-23 Yuzhi Zhang , Haidi Wang , Weijie Chen , Jinzhe Zeng , Linfeng Zhang , Han Wang , Weinan E

This paper develops a generative deep learning model for the synthesis of multiple-input multiple-output (MIMO) active sensing waveforms with desired properties, including constant modulus and a user-defined beampattern. The proposed…

Signal Processing · Electrical Eng. & Systems 2024-12-31 Vesa Saarinen , Robin Rajamäki , Visa Koivunen
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