Related papers: Community recommendations on cryoEM data archiving…
The second workshop on the HEP Analysis Ecosystem took place 23-25 May 2022 at IJCLab in Orsay, to look at progress and continuing challenges in scaling up HEP analysis to meet the needs of HL-LHC and DUNE, as well as the very pressing…
Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational diversity of dynamic biomolecular complexes, often requiring…
Electrospray ion beam deposition (ESIBD) is the intact, chemically selective deposition of molecular ions on surfaces in vacuum. Here, we present a general method and dedicated instrumentation for ESIBD-based cryoEM sample preparation of…
This record contains the proceedings of the 2020 Workshop on Assessing, Explaining, and Conveying Robot Proficiency for Human-Robot Teaming, which was held in conjunction with the 2020 ACM/IEEE International Conference on Human-Robot…
Cloud solutions are increasingly used for a plethora of purposes, including solving memory-intensive and computation-intensive problems. Ensuring the reliability, availability, scalability, and security of cloud solutions, as networked…
Laser flash melting and revitrification experiments have recently improved the time resolution of cryo-electron microscopy (cryo-EM) to the microsecond timescale, making it fast enough to observe many of the protein motions that are…
Constructing of molecular structural models from Cryo-Electron Microscopy (Cryo-EM) density volumes is the critical last step of structure determination by Cryo-EM technologies. Methods have evolved from manual construction by structural…
Cryo-electron microscopy can now routinely deliver atomic resolution structures for a variety of biological systems. The relevance and value of these structures is directly related to their ability to help rationalize experimental…
Background: Single-particle cryo-electron microscopy (cryo-EM) has become a popular tool for structural determination of biological macromolecular complexes. High-resolution cryo-EM reconstruction often requires hundreds of thousands of…
Single particle cryo-electron microscopy has become a critical tool in structural biology over the last decade, able to achieve atomic scale resolution in three dimensional models from hundreds of thousands of (noisy) two-dimensional…
Cryo-electron microscopy (cryo-EM), the subject of the 2017 Nobel Prize in Chemistry, is a technology for determining the 3-D structure of macromolecules from many noisy 2-D projections of instances of these macromolecules, whose…
Cryo-electron microscopy (cryo-EM) has become a major experimental technique to determine the structures of large protein complexes and molecular assemblies, as evidenced by the 2017 Nobel Prize. Although cryo-EM has been drastically…
Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling near-atomic-level visualization of biomolecular assemblies. However, the exponential growth in cryo-EM data throughput and complexity, coupled with diverse…
The computational pipelines of single-particle cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) include an early particle-picking stage, in which a micrograph or tomogram is scanned to extract candidate particles,…
Cloud computing is a cost-effective way for start-up life sciences laboratories to store and manage their data. However, in many instances the data stored over the cloud could be redundant which makes cloud-based data management inefficient…
Cryo-Electron Microscopy (cryo-EM) has become an extremely powerful method for resolving structural details of large biomolecular complexes. However, challenging problems in single-particle methods remain open because of (1) the low…
We review the results of the 1st Extreme Ultraviolet (EUV) Light Sources Code Comparison Workshop, which was held online on 3rd November 2020. The goal of this workshop was to provide a platform for specialists in EUV light source plasma…
A document has recently been posted on the arXiv [1], describing analytical formulas and results of particle tracking simulations, for precision tests of numerical integration algorithms for an EDM (electric dipole moment) storage ring. In…
Macromolecules change their shape (conformation) in the process of carrying out their functions. The imaging by cryo-electron microscopy of rapidly-frozen, individual copies of macromolecules (single particles) is a powerful and general…
Using Machine Learning and Deep Learning to predict cognitive tasks from electroencephalography (EEG) signals has been a fast-developing area in Brain-Computer Interfaces (BCI). However, during the COVID-19 pandemic, data collection and…