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Obtaining 3D information from a single X-ray exposure at high-brilliance sources, such as X-ray free-electron lasers (XFELs) [1] or diffraction-limited storage rings [2], allows the study of fast dynamical processes in their native…

The classical method of determining the atomic structure of complex molecules by analyzing diffraction patterns is currently undergoing drastic developments. Modern techniques for producing extremely bright and coherent X-ray lasers allow a…

Biomolecules · Quantitative Biology 2015-10-12 Tomas Ekeberg , Stefan Engblom , Jing Liu

We introduce a single-frame diffractive imaging method called randomized probe imaging (RPI). In RPI, a sample is illuminated by a structured probe field containing speckles smaller than the sample's typical feature size. Quantitative…

Single-pixel imaging (SPI) offers a cost-effective route to hyperspectral acquisition but struggles to recover high-fidelity spatial and spectral details under extremely low sampling rates, a severely ill-posed inverse problem. While deep…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Hao Zhang , Bilige Xu , Lichen Wei , Xu Ma , Wenyi Ren

Coherent diffraction imaging (CDI) of single molecules at atomic resolution is a major goal for the x-ray free electron lasers (XFELs). However, during an imaging pulse, the fast laser-induced ionization may strongly affect the recorded…

Mesoscale and Nanoscale Physics · Physics 2015-06-05 Zoltan Jurek , Robert Thiele , Beata Ziaja , Robin Santra

We solve the orientation recovery of a tumbling protein in the gas phase from single-event measurements of the spatial positions of its ions after an X-ray laser induced explosion. We simulate diffracted X-ray signal and ion dynamics under…

Chemical Physics · Physics 2026-03-26 Tomas André , Alfredo Bellisario , Nicusor Timneanu , Carl Caleman

Single-pixel imaging, originally developed in light optics, facilitates fast three-dimensional sample reconstruction, as well as probing with light wavelengths undetectable by conventional multi-pixel detectors. However, the spatial…

Single-pixel imaging has emerged as a key technique in fluorescence microscopy, where fast acquisition and reconstruction are crucial. In this context, images are reconstructed from linearly compressed measurements. In practice, total…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Serban C. Tudosie , Valerio Gandolfi , Shivaprasad Varakkoth , Andrea Farina , Cosimo D'Andrea , Simon Arridge

Single-pixel imaging (SPI) is an emerging technique which has attracts wide attention in various research fields. However, restricted by the low reconstruction quality and large amount of measurements, the practical application is still in…

Image and Video Processing · Electrical Eng. & Systems 2018-11-09 Chao Deng , Xuemei Hu , Xiaoxu Li , Jinli Suo , Zhili Zhang , Qionghai Dai

Cryogenic electron microscopy (cryo-EM) provides images from different copies of the same biomolecule in arbitrary orientations. Here, we present an end-to-end unsupervised approach that learns individual particle orientations from cryo-EM…

Image and Video Processing · Electrical Eng. & Systems 2021-07-08 Youssef S. G. Nashed , Frederic Poitevin , Harshit Gupta , Geoffrey Woollard , Michael Kagan , Chuck Yoon , Daniel Ratner

The ill-posed problem of phase retrieval in optics, using one or more intensity measurements, has a multitude of applications using electromagnetic or matter waves. Many phase retrieval algorithms are computed on pixel arrays using discrete…

Image and Video Processing · Electrical Eng. & Systems 2022-09-21 J. A. Pollock , K. S. Morgan , L. C. P. Croton , M. K. Croughan , G. Ruben , N. Yagi , H. Sekiguchi , M. J. Kitchen

Machine learning methods are being introduced at all stages of data reconstruction and analysis in various high-energy physics experiments. We present the development and application of convolutional neural networks with modified…

Instrumentation and Detectors · Physics 2025-04-25 Kalina Dimitrova , Venelin Kozhuharov , Peicho Petkov

In recent years X-ray Free Electron Lasers (XFELs) proved to be unmatched sources of ultrashort pulses of spatially coherent quasimonochromatic X-ray radiation. Diagnostics of XFEL emission properties, in particular pulse duration, spectrum…

The advent of isolated and intense sub-femtosecond X-ray pulses enables tracking of quantummechanical motion of electrons in molecules and solids. The combination of X-ray spectroscopy and diffraction imaging is a powerful approach to…

Diffraction imaging of non-equilibrium dynamics at atomic resolution is becoming possible with X-ray free-electron lasers. However, there are unresolved problems with applying this method to objects that are confined in only one dimension.…

Strongly Correlated Electrons · Physics 2018-02-19 Kenneth R. Beyerlein

We present a method to learn single-view reconstruction of the 3D shape, pose, and texture of objects from categorized natural images in a self-supervised manner. Since this is a severely ill-posed problem, carefully designing a training…

Computer Vision and Pattern Recognition · Computer Science 2019-11-21 Hiroharu Kato , Tatsuya Harada

This paper introduces Spectral Incoherent Diffractive Imaging (SIDI) as a novel method for achieving dark-field imaging of nanostructures with heterogeneous oxidation states. With SIDI, shifts in photoemission profiles can be spatially…

Optics · Physics 2023-12-25 Tamme Wollweber , Kartik Ayyer

Single-molecule force spectroscopy (smFS) is a powerful approach to studying molecular self-organization. However, the coupling of the molecule with the ever-present experimental device introduces artifacts, that complicates the…

Chemical Physics · Physics 2023-04-25 Lars Dingeldein , Pilar Cossio , Roberto Covino

X-ray free-electron lasers (XFELs) are the only sources currently able to produce bright few-fs pulses with tunable photon energies from 100 eV to more than 10 keV. Due to the stochastic SASE operating principles and other technical issues…

We introduce the EMC algorithm for reconstructing a particle's 3D diffraction intensity from very many photon shot-noise limited 2D measurements, when the particle orientation in each measurement is unknown. The algorithm combines a…

Data Analysis, Statistics and Probability · Physics 2010-03-04 Duane Ne-Te Loh , Veit Elser