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Large language models (LLMs) have shown strong ability in generating rich representations across domains such as natural language processing and generation, computer vision, and multimodal learning. However, their application in biomedical…

Genomics · Quantitative Biology 2025-09-30 Luxuan Zhang , Douglas Jiang , Qinglong Wang , Haoqi Sun , Feng Tian

Gene studies are crucial for fields such as protein structure prediction, drug discovery, and cancer genomics, yet they face challenges in fully utilizing the vast and diverse information available. Gene studies require clean, factual…

Databases · Computer Science 2024-12-18 Yuwei Miao , Yuzhi Guo , Hehuan Ma , Jingquan Yan , Feng Jiang , Weizhi An , Jean Gao , Junzhou Huang

Evaluation of reasoning language models gained importance after it was observed that they can combine their existing capabilities into novel traces of intermediate steps before task completion and that the traces can sometimes help them to…

Machine Learning · Computer Science 2025-08-15 Petr Spelda , Vit Stritecky

Foundation models have established unified representations for natural language processing, yet this paradigm remains largely unexplored for tabular data. Existing methods face fundamental limitations: LLM-based approaches lack…

Computation and Language · Computer Science 2026-05-07 Minjie Qiang , Mingming Zhang , Xiaoyi Bao , Xing Fu , Yu Cheng , Weiqiang Wang , Zhongqing Wang , Ningtao Wang

This paper presents the Ensemble Nucleotide Byte-level Encoder-Decoder (ENBED) foundation model, analyzing DNA sequences at byte-level precision with an encoder-decoder Transformer architecture. ENBED uses a sub-quadratic implementation of…

Machine Learning · Computer Science 2024-08-26 Aditya Malusare , Harish Kothandaraman , Dipesh Tamboli , Nadia A. Lanman , Vaneet Aggarwal

Language models (LMs) built upon deep neural networks (DNNs) have recently demonstrated breakthrough effectiveness in software engineering tasks such as code generation, completion, and repair. This has paved the way for the emergence of…

Software Engineering · Computer Science 2025-01-06 Jingzhi Gong , Vardan Voskanyan , Paul Brookes , Fan Wu , Wei Jie , Jie Xu , Rafail Giavrimis , Mike Basios , Leslie Kanthan , Zheng Wang

The task of understanding and interpreting the complex information encoded within genomic sequences remains a grand challenge in biological research and clinical applications. In this context, recent advancements in large language model…

Genomics · Quantitative Biology 2024-09-25 Qihang Zhao , Chi Zhang , Weixiong Zhang

The use of machine learning (ML) based techniques has become increasingly popular in the field of bioacoustics over the last years. Fundamental requirements for the successful application of ML based techniques are curated, agreed upon,…

The Basic Local Alignment Search Tool (BLAST) is currently the most popular method for searching databases of biological sequences. BLAST compares sequences via similarity defined by a weighted edit distance, which results in it being…

Biomolecules · Quantitative Biology 2020-10-29 Amir Shanehsazzadeh , David Belanger , David Dohan

The evaluation of ranking tasks remains a significant challenge in natural language processing (NLP), particularly due to the lack of direct labels for results in real-world scenarios. Benchmark datasets play a crucial role in providing…

Information Retrieval · Computer Science 2025-03-04 Yan Wang , Lingfei Qian , Xueqing Peng , Jimin Huang , Dongji Feng

We are now witnessing significant progress of deep learning methods in a variety of tasks (or datasets) of proteins. However, there is a lack of a standard benchmark to evaluate the performance of different methods, which hinders the…

Machine Learning · Computer Science 2022-09-20 Minghao Xu , Zuobai Zhang , Jiarui Lu , Zhaocheng Zhu , Yangtian Zhang , Chang Ma , Runcheng Liu , Jian Tang

Machine Learning-guided solutions for protein learning tasks have made significant headway in recent years. However, success in scientific discovery tasks is limited by the accessibility of well-defined and labeled in-domain data. To tackle…

Machine Learning · Computer Science 2023-01-06 Ria Vinod , Pin-Yu Chen , Payel Das

Effective processing, interpretation, and management of sensor data have emerged as a critical component of cyber-physical systems. Traditionally, processing sensor data requires profound theoretical knowledge and proficiency in…

Artificial Intelligence · Computer Science 2025-04-01 Pengrui Quan , Xiaomin Ouyang , Jeya Vikranth Jeyakumar , Ziqi Wang , Yang Xing , Mani Srivastava

Entity Matching (EM)--the task of determining whether two data records refer to the same real-world entity--is a core task in data integration. Recent advances in deep learning have set a new standard for EM, particularly through…

Databases · Computer Science 2026-03-18 Nicholas Pulsone , Roee Shraga , Gregory Goren

Named entity recognition (NER) is a widely studied task in natural language processing. Recently, a growing number of studies have focused on the nested NER. The span-based methods, considering the entity recognition as a span…

Computation and Language · Computer Science 2021-06-22 Zeqi Tan , Yongliang Shen , Shuai Zhang , Weiming Lu , Yueting Zhuang

Ontology matching (OM) plays an essential role in enabling semantic interoperability and integration across heterogeneous knowledge sources, particularly in the biomedical domain which contains numerous complex concepts related to diseases…

Artificial Intelligence · Computer Science 2026-04-03 Yiping Song , Jiaoyan Chen , Renate A. Schmidt

Large Language Models (LLMs) have achieved remarkable progress in recent years, driving their adoption across a wide range of domains, including computer security. In reverse engineering, LLMs are increasingly applied to critical tasks such…

Cryptography and Security · Computer Science 2026-05-01 Jun Yeon Won , Xin Jin , Shiqing Ma , Zhiqiang Lin

Feature embedding methods have been proposed in literature to represent sequences as numeric vectors to be used in some bioinformatics investigations, such as family classification and protein structure prediction. Recent theoretical…

Semantically meaningful sentence embeddings are important for numerous tasks in natural language processing. To obtain such embeddings, recent studies explored the idea of utilizing synthetically generated data from pretrained language…

Computation and Language · Computer Science 2022-08-31 Taehee Kim , ChaeHun Park , Jimin Hong , Radhika Dua , Edward Choi , Jaegul Choo
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