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Tandem mass spectrometry has played a pivotal role in advancing proteomics, enabling the high-throughput analysis of protein composition in biological tissues. Many deep learning methods have been developed for \emph{de novo} peptide…

Quantitative Methods · Quantitative Biology 2024-11-01 Jingbo Zhou , Shaorong Chen , Jun Xia , Sizhe Liu , Tianze Ling , Wenjie Du , Yue Liu , Jianwei Yin , Stan Z. Li

Recent work has shown that generation from a prompted or fine-tuned language model can perform well at semantic parsing when the output is constrained to be a valid semantic representation. We introduce BenchCLAMP, a Benchmark to evaluate…

Computation and Language · Computer Science 2024-01-11 Subhro Roy , Sam Thomson , Tongfei Chen , Richard Shin , Adam Pauls , Jason Eisner , Benjamin Van Durme

Deep neural networks (DNNs) have proven successful in a wide variety of applications such as speech recognition and synthesis, computer vision, machine translation, and game playing, to name but a few. However, existing deep neural network…

Machine Learning · Computer Science 2022-08-08 Ramit Pahwa

There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Genomics · Quantitative Biology 2024-10-29 Wang Liang

Deep neural networks (DNNs) are known for extracting useful information from large amounts of data. However, the representations learned in DNNs are typically hard to interpret, especially in dense layers. One crucial issue of the classical…

Neural and Evolutionary Computing · Computer Science 2021-05-06 Yuyang Gao , Giorgio A. Ascoli , Liang Zhao

We propose Diverse Embedding Neural Network (DENN), a novel architecture for language models (LMs). A DENNLM projects the input word history vector onto multiple diverse low-dimensional sub-spaces instead of a single higher-dimensional…

Computation and Language · Computer Science 2015-04-17 Kartik Audhkhasi , Abhinav Sethy , Bhuvana Ramabhadran

Model editing aims to correct errors and outdated knowledge in the Large language models (LLMs) with minimal cost. Prior research has proposed a variety of datasets to assess the effectiveness of these model editing methods. However, most…

Computation and Language · Computer Science 2025-05-27 Li Zeng , Zeming Liu , Chong Feng , Heyan Huang , Yuhang Guo

The capability of accurate prediction of protein functions and properties is essential in the biotechnology industry, e.g. drug development and artificial protein synthesis, etc. The main challenges of protein function prediction are the…

Quantitative Methods · Quantitative Biology 2021-12-02 Wei-Cheng Tseng , Po-Han Chi , Jia-Hua Wu , Min Sun

The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

We introduce GENomic Encoding REpresentation with Language Model (GENEREL), a framework designed to bridge genetic and biomedical knowledge bases. What sets GENEREL apart is its ability to fine-tune language models to infuse biological…

Machine Learning · Computer Science 2024-10-15 Hongyi Yuan , Suqi Liu , Kelly Cho , Katherine Liao , Alexandre Pereira , Tianxi Cai

Sentence embedding is essential for many NLP tasks, with contrastive learning methods achieving strong performance using annotated datasets like NLI. Yet, the reliance on manual labels limits scalability. Recent studies leverage large…

Computation and Language · Computer Science 2025-06-05 Liyang He , Chenglong Liu , Rui Li , Zhenya Huang , Shulan Ruan , Jun Zhou , Enhong Chen

Various human activities can be abstracted into a sequence of actions in natural text, i.e. cooking, repairing, manufacturing, etc. Such action sequences heavily depend on the executing order, while disorder in action sequences leads to…

Computation and Language · Computer Science 2023-06-08 Weizhi Wang , Hong Wang , Xifeng Yan

Recognizing named entities (NEs) is commonly conducted as a classification problem that predicts a class tag for a word or a NE candidate in a sentence. In shallow structures, categorized features are weighted to support the prediction.…

Computation and Language · Computer Science 2022-02-01 Yanping Chen , Lefei Wu , Qinghua Zheng , Ruizhang Huang , Jun Liu , Liyuan Deng , Junhui Yu , Yongbin Qing , Bo Dong , Ping Chen

Code understanding is an increasingly important application of Artificial Intelligence. A fundamental aspect of understanding code is understanding text about code, e.g., documentation and forum discussions. Pre-trained language models…

Computation and Language · Computer Science 2021-09-16 Ibrahim Abdelaziz , Julian Dolby , Jamie McCusker , Kavitha Srinivas

Network embedding methods map a network's nodes to vectors in an embedding space, in such a way that these representations are useful for estimating some notion of similarity or proximity between pairs of nodes in the network. The quality…

Social and Information Networks · Computer Science 2022-02-02 Alexandru Mara , Jefrey Lijffijt , Tijl De Bie

Malware is becoming increasingly complex and widespread, making it essential to develop more effective and timely detection methods. Traditional static analysis often fails to defend against modern threats that employ code obfuscation,…

Machine Learning · Computer Science 2025-09-19 Wadduwage Shanika Perera , Haodi Jiang

Understanding the relationships among genes, compounds, and their interactions in living organisms remains limited due to technological constraints and the complexity of biological data. Deep learning has shown promise in exploring these…

Advancements in genomic research such as high-throughput sequencing techniques have driven modern genomic studies into "big data" disciplines. This data explosion is constantly challenging conventional methods used in genomics. In parallel…

Genomics · Quantitative Biology 2023-10-06 Tianwei Yue , Yuanxin Wang , Longxiang Zhang , Chunming Gu , Haoru Xue , Wenping Wang , Qi Lyu , Yujie Dun

Seed science is essential for modern agriculture, directly influencing crop yields and global food security. However, challenges such as interdisciplinary complexity and high costs with limited returns hinder progress, leading to a shortage…

Computation and Language · Computer Science 2025-05-20 Jie Ying , Zihong Chen , Zhefan Wang , Wanli Jiang , Chenyang Wang , Zhonghang Yuan , Haoyang Su , Huanjun Kong , Fan Yang , Nanqing Dong

Tokens serve as the basic units of representation in DNA language models (DNALMs), yet their design remains underexplored. Unlike natural language, DNA lacks inherent token boundaries or predefined compositional rules, making tokenization a…

Machine Learning · Computer Science 2026-04-13 Nan Huang , Xiaoxiao Zhou , Junxia Cui , Mario Tapia-Pacheco , Tiffany Amariuta , Yang Li , Jingbo Shang