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DNA sequencing is revolutionising the field of medicine. DNA sequencers, the machines which perform DNA sequencing, have evolved from the size of a fridge to that of a mobile phone over the last two decades. The cost of sequencing a human…

Genomics · Quantitative Biology 2021-01-14 Hasindu Gamaarachchi

Inspired by the success of large language models (LLM) for DNA and proteins, several LLM for RNA have been developed recently. RNA-LLM uses large datasets of RNA sequences to learn, in a self-supervised way, how to represent each RNA base…

Artificial Intelligence · Computer Science 2025-02-04 L. I. Zablocki , L. A. Bugnon , M. Gerard , L. Di Persia , G. Stegmayer , D. H. Milone

Inferring the structural properties of a protein from its amino acid sequence is a challenging yet important problem in biology. Structures are not known for the vast majority of protein sequences, but structure is critical for…

Machine Learning · Computer Science 2019-10-17 Tristan Bepler , Bonnie Berger

Large language models (LLMs) have shown great promise in generating structured diagrams from natural language descriptions, particularly Mermaid sequence diagrams for software engineering. However, the lack of existing benchmarks to assess…

Software Engineering · Computer Science 2026-04-28 Basel Shbita , Farhan Ahmed , Chad DeLuca

Generative language models (LMs) are increasingly used for document class-prediction tasks and promise enormous improvements in cost and efficiency. Existing research often examines simple classification tasks, but the capability of LMs to…

Computation and Language · Computer Science 2023-10-31 Rosamond Thalken , Edward H. Stiglitz , David Mimno , Matthew Wilkens

Existing Protein Language Models (PLMs) often suffer from limited adaptability to multiple tasks and exhibit poor generalization across diverse biological contexts. In contrast, general-purpose Large Language Models (LLMs) lack the…

Machine Learning · Computer Science 2026-02-23 Yujia Wang , Jihong Guan , Wengen Li , Shuigeng Zhou , Xuhong Wang

Language models are now capable of solving tasks that require dealing with long sequences consisting of hundreds of thousands of tokens. However, they often fail on tasks that require repetitive use of simple rules, even on sequences that…

Computation and Language · Computer Science 2024-10-10 Mirelle Bueno , Roberto Lotufo , Rodrigo Nogueira

We propose an unsupervised method to obtain cross-lingual embeddings without any parallel data or pre-trained word embeddings. The proposed model, which we call multilingual neural language models, takes sentences of multiple languages as…

Computation and Language · Computer Science 2018-09-10 Takashi Wada , Tomoharu Iwata

The meaningful use of electronic health records (EHR) continues to progress in the digital era with clinical decision support systems augmented by artificial intelligence. A priority in improving provider experience is to overcome…

Computation and Language · Computer Science 2023-01-30 Yanjun Gao , Dmitriy Dligach , Timothy Miller , John Caskey , Brihat Sharma , Matthew M Churpek , Majid Afshar

The development and evaluation of Large Language Models (LLMs) has primarily focused on their task-solving capabilities, with recent models even surpassing human performance in some areas. However, this focus often neglects whether…

Computation and Language · Computer Science 2025-07-29 Yanzhu Guo , Guokan Shang , Chloé Clavel

Foundation models in genomics have shown mixed success compared to their counterparts in natural language processing. Yet, the reasons for their limited effectiveness remain poorly understood. In this work, we investigate the role of…

Machine Learning · Computer Science 2026-04-07 Maxime Rochkoulets , Lovro Vrček , Mile Šikić

Large Language Models (LLMs) demonstrate remarkable generalizability across diverse tasks, yet genomic foundation models (GFMs) still require separate finetuning for each downstream application, creating significant overhead as model sizes…

Genomics · Quantitative Biology 2025-02-07 Zehui Li , Vallijah Subasri , Yifei Shen , Dongsheng Li , Yiren Zhao , Guy-Bart Stan , Caihua Shan

Designing RNA molecules has garnered recent interest in medicine, synthetic biology, biotechnology and bioinformatics since many functional RNA molecules were shown to be involved in regulatory processes for transcription, epigenetics and…

Machine Learning · Computer Science 2019-04-15 Frederic Runge , Danny Stoll , Stefan Falkner , Frank Hutter

Requirements Engineering (RE) is the initial step towards building a software system. The success or failure of a software project is firmly tied to this phase, based on communication among stakeholders using natural language. The problem…

Software Engineering · Computer Science 2021-12-07 Mohammad Kasra Habib , Stefan Wagner , Daniel Graziotin

The Semantic Layered Embedding Diffusion (SLED) mechanism redefines the representation of hierarchical semantics within transformer-based architectures, enabling enhanced contextual consistency across a wide array of linguistic tasks. By…

Computation and Language · Computer Science 2025-03-26 Irin Kabakum , Thomas Montgomery , Daniel Ravenwood , Genevieve Harrington

Bidirectional Long Short-Term Memory Recurrent Neural Network (BLSTM-RNN) has been shown to be very effective for modeling and predicting sequential data, e.g. speech utterances or handwritten documents. In this study, we propose to use…

Computation and Language · Computer Science 2015-11-03 Peilu Wang , Yao Qian , Frank K. Soong , Lei He , Hai Zhao

We present a new approach for benchmarking Large Language Model (LLM) capabilities on research-level mathematics. Existing benchmarks largely rely on static, hand-curated sets of contest or textbook-style problems as proxies for…

Artificial Intelligence · Computer Science 2026-03-02 Antoine Peyronnet , Fabian Gloeckle , Amaury Hayat

Uncovering hidden symbolic laws from time series data, as an aspiration dating back to Kepler's discovery of planetary motion, remains a core challenge in scientific discovery and artificial intelligence. While Large Language Models show…

Artificial Intelligence · Computer Science 2026-04-27 Zewen Liu , Juntong Ni , Xianfeng Tang , Max S. Y. Lau , Qi He , Wenpeng Yin , Wei Jin

We introduce a comprehensive Linguistic Benchmark designed to evaluate the limitations of Large Language Models (LLMs) in domains such as logical reasoning, spatial intelligence, and linguistic understanding, among others. Through a series…

Artificial Intelligence · Computer Science 2024-06-04 Sean Williams , James Huckle

We present BLESS, a comprehensive performance benchmark of the most recent state-of-the-art large language models (LLMs) on the task of text simplification (TS). We examine how well off-the-shelf LLMs can solve this challenging task,…

Computation and Language · Computer Science 2023-10-25 Tannon Kew , Alison Chi , Laura Vásquez-Rodríguez , Sweta Agrawal , Dennis Aumiller , Fernando Alva-Manchego , Matthew Shardlow
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