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The attributable risk, often called the population attributable risk, is in many epidemiological contexts a more relevant measure of exposure-disease association than the excess risk, relative risk, or odds ratio. When estimating…

Statistics Theory · Mathematics 2008-12-31 Daniel B. Rubin

This paper develops an agent-based disease spread model on a contact network in an effort to guide efforts at surveillance testing in small to moderate facilities such as nursing homes and meat-packing plants. The model employs Monte Carlo…

Populations and Evolution · Quantitative Biology 2021-10-04 Yanyue Ding , Sudesh K. Agrawal , Jincheng Cao , Lauren Meyers , John J. Hasenbein

Causality has been the issue of philosophic debate since Hippocrates. It is used in formal verification and testing, e.g., to explain counterexamples or construct fault trees. Recent work defines actual causation in terms of Pearl's…

Logic in Computer Science · Computer Science 2019-11-01 Robert Künnemann , Deepak Garg , Michael Backes

Optimal control of interdependent epidemics spreading over complex networks is a critical issue. We first establish a framework to capture the coupling between two epidemics, and then analyze the system's equilibrium states by categorizing…

Systems and Control · Computer Science 2017-10-19 Juntao Chen , Rui Zhang , Quanyan Zhu

Detecting anomalies in large sets of observations is crucial in various applications, such as epidemiological studies, gene expression studies, and systems monitoring. We consider settings where the units of interest result in multiple…

Methodology · Statistics 2025-12-22 Ivo V. Stoepker , Rui M. Castro , Ery Arias-Castro

This paper discusses the fundamental principles of causal inference - the area of statistics that estimates the effect of specific occurrences, treatments, interventions, and exposures on a given outcome from experimental and observational…

Methodology · Statistics 2021-12-03 Francesca Dominici , Falco J. Bargagli-Stoffi , Fabrizia Mealli

Epidemiological contact network models have emerged as an important tool in understanding and predicting the spread of infectious disease, due to their capacity to engage individual heterogeneity that may underlie essential dynamics of a…

Physics and Society · Physics 2019-10-28 Jack Leitch , Kathleen A. Alexander , Srijan Sengupta

The fundamental models of epidemiology describe the progression of an infectious disease through a population using compartmentalized differential equations, but do not incorporate population-level heterogeneity in infection susceptibility.…

Populations and Evolution · Quantitative Biology 2023-08-04 Christopher Rose , Andrew J. Medford , C. Franklin Goldsmith , Tejs Vegge , Joshua S. Weitz , Andrew A. Peterson

Testing is a crucial control mechanism in the beginning phase of an epidemic when the vaccines are not yet available. It enables the public health authority to detect and isolate the infected cases from the population, thereby limiting the…

In this paper we first introduce the general stochastic epidemic model for the spread of infectious diseases. Then we give methods for inferring model parameters such as the basic reproduction number $R_0$ and vaccination coverage $v_c$…

Methodology · Statistics 2014-11-14 Tom Britton , Federica Giardina

Contact tracing is one of the most important control measures deployed during epidemics. Relying on the identification of contacts of known infected individuals, it necessitates a network perspective. Although pairwise models have been used…

Physics and Society · Physics 2026-03-05 Giulia de Meijere , Andrea Pugliese , Gerardo Iñiguez , Péter L. Simon , István Z. Kiss

Incidence vs Cumulative Cases (ICC) curves are introduced and shown to provide a simple framework for parameter identification in the case of the most elementary epidemiological model, consisting of susceptible, infected, and removed…

Populations and Evolution · Quantitative Biology 2021-04-14 Joceline Lega

Containment of epidemic outbreaks entails great societal and economic costs. Cost-effective containment strategies rely on efficiently identifying infected individuals, making the best possible use of the available testing resources.…

Populations and Evolution · Quantitative Biology 2020-12-01 Laura Natali , Saga Helgadottir , Onofrio M. Marago , Giovanni Volpe

Simple ideas, endowed from the mathematical theory of control, are used in order to analyze in general grounds the human immune system. The general principles are minimization of the pathogen load and economy of resources. They should…

Tissues and Organs · Quantitative Biology 2016-07-12 Augusto Gonzalez

Epidemiological compartmental models are useful for understanding infectious disease propagation and directing public health policy decisions. Calibration of these models is an important step in offering accurate forecasts of disease…

Machine Learning · Computer Science 2023-12-12 Nikunj Gupta , Anh Mai , Azza Abouzied , Dennis Shasha

In recent years, epidemic policy-making models are increasingly being used to provide reference for governors on prevention and control policies against catastrophic epidemics such as SARS, H1N1 and COVID-19. Existing studies are currently…

Artificial Intelligence · Computer Science 2024-03-19 Zhiyi Tan , Bingkun Bao

Higher educational institutions constantly look for ways to meet students' needs and support them through graduation. Recent work in the field of learning analytics have developed methods for grade prediction and course recommendations.…

Applications · Statistics 2019-06-12 Prableen Kaur , Agoritsa Polyzou , George Karypis

Compartmental models have long served as important tools in mathematical epidemiology, with their usefulness highlighted by the recent COVID-19 pandemic. However, most of the classical models fail to account for certain features of this…

Dynamical Systems · Mathematics 2023-08-21 Monique Chyba , Taylor Klotz , Yuriy Mileyko , Corey Shanbrom

A key problem in modelling the evolution dynamics of infectious diseases is the mathematical representation of the mechanism of transmission of the contagion. Models with a finite number of subpopulations can be described via systems of…

Optimization and Control · Mathematics 2017-03-09 Sebastian Anita , Vincenzo Capasso

Understanding age-group dynamics of infectious diseases is a fundamental issue for both scientific study and policymaking. Age-structure epidemic models were developed in order to study and improve our understanding of these dynamics. By…

Populations and Evolution · Quantitative Biology 2019-11-22 Rami Yaari , Amit Huppert , Itai Dattner