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Despite being very powerful in standard learning settings, deep learning models can be extremely brittle when deployed in scenarios different from those on which they were trained. Domain generalization methods investigate this problem and…

Computer Vision and Pattern Recognition · Computer Science 2021-01-28 Francesco Cappio Borlino , Antonio D'Innocente , Tatiana Tommasi

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

Domain shift is a significant problem in histopathology. There can be large differences in data characteristics of whole-slide images between medical centers and scanners, making generalization of deep learning to unseen data difficult. To…

Computer Vision and Pattern Recognition · Computer Science 2019-09-27 Karin Stacke , Gabriel Eilertsen , Jonas Unger , Claes Lundström

Deep learning models for computer vision often suffer from poor generalization when deployed in real-world settings, especially when trained on synthetic data due to the well-known Sim2Real gap. Despite the growing popularity of style…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Dustin Eisenhardt , Timothy Schaumlöffel , Alperen Kantarci , Gemma Roig

Despite notable advancements, the integration of deep learning (DL) techniques into impactful clinical applications, particularly in the realm of digital histopathology, has been hindered by challenges associated with achieving robust…

Image and Video Processing · Electrical Eng. & Systems 2024-07-04 Sebastian Doerrich , Francesco Di Salvo , Christian Ledig

Traditional domain generalization methods often rely on domain alignment to reduce inter-domain distribution differences and learn domain-invariant representations. However, domain shifts are inherently difficult to eliminate, which limits…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Yuheng Xu , Taiping Zhang

Domain generalization (DG) approaches intend to extract domain invariant features that can lead to a more robust deep learning model. In this regard, style augmentation is a strong DG method taking advantage of instance-specific feature…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Zheyuan Zhang , Bin Wang , Debesh Jha , Ugur Demir , Ulas Bagci

Data augmentation is widely used to enhance generalization in visual classification tasks. However, traditional methods struggle when source and target domains differ, as in domain adaptation, due to their inability to address domain gaps.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Khawar Islam , Muhammad Zaigham Zaheer , Arif Mahmood , Karthik Nandakumar , Naveed Akhtar

Due to the limitation of available labeled data, medical image segmentation is a challenging task for deep learning. Traditional data augmentation techniques have been shown to improve segmentation network performances by optimizing the…

Image and Video Processing · Electrical Eng. & Systems 2022-11-03 Kevin Ginsburger

In this paper, we consider the problem of domain generalization in semantic segmentation, which aims to learn a robust model using only labeled synthetic (source) data. The model is expected to perform well on unseen real (target) domains.…

Computer Vision and Pattern Recognition · Computer Science 2022-10-14 Zhun Zhong , Yuyang Zhao , Gim Hee Lee , Nicu Sebe

The insertion of deep learning in medical image analysis had lead to the development of state-of-the art strategies in several applications such a disease classification, as well as abnormality detection and segmentation. However, even the…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Mauricio Orbes-Arteaga , Thomas Varsavsky , Lauge Sorensen , Mads Nielsen , Akshay Pai , Sebastien Ourselin , Marc Modat , M Jorge Cardoso

Due to domain shifts across diverse medical imaging modalities, learned segmentation models often suffer significant performance degradation during deployment. We posit that these domain shifts can generally be categorized into two main…

Image and Video Processing · Electrical Eng. & Systems 2025-11-20 Zhiqiang Shen , Peng Cao , Jinzhu Yang , Osmar R. Zaiane , Zhaolin Chen

The different stain styles of cytopathological images have a negative effect on the generalization ability of automated image analysis algorithms. This article proposes a new framework that normalizes the stain style for cytopathological…

Image and Video Processing · Electrical Eng. & Systems 2019-09-12 Xihao Chen , Jingya Yu , Li Chen , Shaoqun Zeng , Xiuli Liu , Shenghua Cheng

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Style transfer generates an image whose content comes from one image and style from the other. Image-to-image translation approaches with disentangled representations have been shown effective for style transfer between two image…

Computer Vision and Pattern Recognition · Computer Science 2020-08-06 Hsin-Yu Chang , Zhixiang Wang , Yung-Yu Chuang

Histopathology image classification is crucial for the accurate identification and diagnosis of various diseases but requires large and diverse datasets. Obtaining such datasets, however, is often costly and time-consuming due to the need…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Leire Benito-Del-Valle , Aitor Alvarez-Gila , Itziar Eguskiza , Cristina L. Saratxaga

Artistic style transfer is the problem of synthesizing an image with content similar to a given image and style similar to another. Although recent feed-forward neural networks can generate stylized images in real-time, these models produce…

Computer Vision and Pattern Recognition · Computer Science 2018-11-22 Mohammad Babaeizadeh , Golnaz Ghiasi

The application of supervised deep learning methods in digital pathology is limited due to their sensitivity to domain shift. Digital Pathology is an area prone to high variability due to many sources, including the common practice of…

Image and Video Processing · Electrical Eng. & Systems 2020-12-24 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert

Histopathology whole slide images (WSIs) can reveal significant inter-hospital variability such as illumination, color or optical artifacts. These variations, caused by the use of different scanning protocols across medical centers…

Computer Vision and Pattern Recognition · Computer Science 2022-07-01 Marin Scalbert , Maria Vakalopoulou , Florent Couzinié-Devy

Domain generalization aims to develop models that are robust to distribution shifts. Existing methods focus on learning invariance across domains to enhance model robustness, and data augmentation has been widely used to learn invariant…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Yingnan Liu , Yingtian Zou , Rui Qiao , Fusheng Liu , Mong Li Lee , Wynne Hsu