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This paper studies quantum optimization baselines for the Generalized Traveling Salesman Problem (GTSP), a clustered routing problem that naturally models variant selection and sequencing problems under discrete alternatives. We propose a…

As DNA data storage moves closer to practical deployment, minimizing sequencing coverage depth is essential to reduce both operational costs and retrieval latency. This paper addresses the recently studied Random Access Problem, which…

Information Theory · Computer Science 2026-01-13 Chen Wang , Eitan Yaakobi

Early hardware limitations of GPU (lack of synchronization primitives and limited memory caching mechanisms) can make GPU-based computation inefficient. Now Bio-technologies bring more chances to Bioinformatics and Biological Engineering.…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-10-29 YuKun Zhong , BaoQiu Wang , JianBiao Lin , Chen Tao , Che Nian , Xie Wen

A new set of DNA base-nucleic acid codes and their hypercomplex number representation have been introduced for taking the probability of each nucleotide into full account. A new scoring system has been proposed to suit the hypercomplex…

Other Quantitative Biology · Quantitative Biology 2014-03-12 Jian-Jun Shu , Li Shan Ouw

Quantum Approximate Optimization Algorithm (QAOA) is a hybrid classical-quantum algorithm to approximately solve NP optimization problems such as MAX-CUT. We describe a new application area of QAOA circuits: graph structure discovery. We…

Quantum Physics · Physics 2020-01-01 Mario Szegedy

We propose a genetic algorithm (GA) for hyperparameter optimization of artificial neural networks which includes chromosomal crossover as well as a decoupling of parameters (i.e., weights and biases) from hyperparameters (e.g., learning…

Neural and Evolutionary Computing · Computer Science 2019-01-15 Aaron Vose , Jacob Balma , Alex Heye , Alessandro Rigazzi , Charles Siegel , Diana Moise , Benjamin Robbins , Rangan Sukumar

Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of…

Soft Condensed Matter · Physics 2015-06-25 Johan Lagerqvist , Michael Zwolak , Massimiliano Di Ventra

Next-generation sequencing technologies provide a revolutionary tool for generating gene expression data. Starting with a fixed RNA sample, they construct a library of millions of differentially abundant short sequence tags or "reads",…

Quantitative Methods · Quantitative Biology 2014-05-13 Dimitrios V. Vavoulis , Julian Gough

The quantum approximate optimization algorithm (QAOA) is one of the most promising candidates for achieving quantum advantage through quantum-enhanced combinatorial optimization. Optimal QAOA parameter concentration effects for special…

Quantum Physics · Physics 2024-07-10 Jose Falla , Quinn Langfitt , Yuri Alexeev , Ilya Safro

Significant research has been carried out recently to find the optimal path in network routing. Among them, the evolutionary algorithm approach is an area where work is carried out extensively. We in this paper have used particle swarm…

Networking and Internet Architecture · Computer Science 2014-07-22 Kavitha Sooda , T. R. Gopalakrishnan Nair

The growing variety of quantum hardware technologies, each with unique peculiarities such as connectivity and native gate sets, creates challenges when selecting the best platform for executing a specific quantum circuit. This selection…

Quantum Physics · Physics 2026-01-29 Antonio Tudisco , Deborah Volpe , Giacomo Orlandi , Giovanna Turvani

Statistical analysis of DNA mixtures is known to pose computational challenges due to the enormous state space of possible DNA profiles. We propose a Bayesian network representation for genotypes, allowing computations to be performed…

Methodology · Statistics 2014-02-21 Therese Graversen , Steffen Lauritzen

The Quantum approximate optimization algorithm (QAOA) is one of the most promising candidates for achieving quantum advantage through quantum-enhanced combinatorial optimization. In a typical QAOA setup, a set of quantum circuit parameters…

Quantum Physics · Physics 2021-06-15 Alexey Galda , Xiaoyuan Liu , Danylo Lykov , Yuri Alexeev , Ilya Safro

DNA sequencing allows for the determination of the genetic code of an organism, and therefore is an indispensable tool that has applications in Medicine, Life Sciences, Evolutionary Biology, Food Sciences and Technology, and Agriculture. In…

Quantum Physics · Physics 2023-04-24 Nouhaila Innan , Muhammad Al-Zafar Khan

Quantum algorithms offer a compelling new avenue for addressing difficult NP-complete optimization problems, such as the Generalized Assignment Problem (GAP). Given the operational constraints of contemporary Noisy Intermediate-Scale…

Quantum Physics · Physics 2025-11-05 Carlo Mastroianni , Francesco Plastina , Jacopo Settino , Andrea Vinci

Quantum adiabatic evolution provides a general technique for the solution of combinatorial search problems on quantum computers. We present the results of a numerical study of a particular application of quantum adiabatic evolution, the…

Quantum Physics · Physics 2018-12-20 Andrew M. Childs , Edward Farhi , Jeffrey Goldstone , Sam Gutmann

Establishing quantum advantage for variational quantum algorithms is an important direction in quantum computing. In this work, we apply the Quantum Approximate Optimisation Algorithm (QAOA) -- a popular variational quantum algorithm for…

Quantum Physics · Physics 2024-01-08 Andrew El-Kadi , Roberto Bondesan

We present a family of \textit{Gaussian Mixture Approximation} (GMA) samplers for sampling unnormalised target densities, encompassing \textit{weights-only GMA} (W-GMA), \textit{Laplace Mixture Approximation} (LMA),…

Machine Learning · Computer Science 2025-10-01 Yongchao Huang

Traditional stereo matching algorithms like Semi-Global Block Matching (SGBM) with Weighted Least Squares (WLS) filtering offer speed advantages over neural networks for UAV applications, generating disparity maps in approximately 0.5…

Computer Vision and Pattern Recognition · Computer Science 2025-12-08 Yida Lin , Bing Xue , Mengjie Zhang , Sam Schofield , Richard Green
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