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Covering alignment problems arise from recent developments in genomics; so called pan-genome graphs are replacing reference genomes, and advances in haplotyping enable full content of diploid genomes to be used as basis of sequence…

Computational Complexity · Computer Science 2018-05-23 Romeo Rizzi , Massimo Cairo , Veli Mäkinen , Alexandru I. Tomescu , Daniel Valenzuela

With the rapid advancement of quantum computing, Quantum Approximate Optimization Algorithm (QAOA) is considered as a promising candidate to demonstrate quantum supremacy, which exponentially solves a class of Quadratic Unconstrained Binary…

Quantum Physics · Physics 2023-10-11 Bo Yue , Shibei Xue , Yu Pan , Min Jiang , Daoyi Dong

The task of Multiple Sequence Alignment (MSA) is a constrained combinatorial optimization problem that is generally considered a complex computational problem. In this paper, we first present a binary encoding of MSA and devise a…

Reconstructing components of a genomic mixture from data obtained by means of DNA sequencing is a challenging problem encountered in a variety of applications including single individual haplotyping and studies of viral communities.…

Genomics · Quantitative Biology 2019-11-14 Ziqi Ke , Haris Vikalo

In real-time trajectory planning for unmanned vehicles, on-board sensors, radars and other instruments are used to collect information on possible obstacles to be avoided and pathways to be followed. Since, in practice, observations of the…

Methodology · Statistics 2013-09-25 Adriano Zanin Zambom , Julian A. A. Collazos , Ronaldo Dias

Quantum search algorithms are considered in the context of protein sequence comparison in biocomputing. Given a sample protein sequence of length m (i.e m residues), the problem considered is to find an optimal match in a large database…

Quantum Physics · Physics 2009-11-06 Lloyd C. L. Hollenberg

This paper introduces a quantum-classical hybrid algorithm for generalized pattern search (GPS) algorithms. We introduce a quantum search step algorithm using amplitude amplification, which reduces the number of oracle calls needed during…

Quantum Physics · Physics 2024-10-02 Colton Mikes , Ismael R. de Farias , David Huckleberry Gutman , Victoria E. Howle

The quantum approximate optimization algorithm (QAOA) has numerous promising applications in solving the combinatorial optimization problems on near-term Noisy Intermediate Scalable Quantum (NISQ) devices. QAOA has a quantum-classical…

Quantum Physics · Physics 2022-02-17 Xinwei Lee , Yoshiyuki Saito , Dongsheng Cai , Nobuyoshi Asai

While Annealing Machines (AM) have shown increasing capabilities in solving complex combinatorial problems, positioning themselves as a more immediate alternative to the expected advances of future fully quantum solutions, there are still…

Artificial Intelligence · Computer Science 2025-01-13 Pablo Loyola , Kento Hasegawa , Andres Hoyos-Idobro , Kazuo Ono , Toyotaro Suzumura , Yu Hirate , Masanao Yamaoka

Genomics is changing our understanding of humans, evolution, diseases, and medicines to name but a few. As sequencing technology is developed collecting DNA sequences takes less time thereby generating more genetic data every day. Today the…

Quantitative Methods · Quantitative Biology 2020-07-29 Sahand Salamat , Tajana Rosing

Combinatorial optimization is an important application targeted by quantum computing. However, near-term hardware constraints make quantum algorithms unlikely to be competitive when compared to high-performing classical heuristics on large…

Quantum Physics · Physics 2021-06-14 Charles Moussa , Hao Wang , Henri Calandra , Thomas Bäck , Vedran Dunjko

DNA storage is now being considered as a new archival storage method for its durability and high information density, but still facing some challenges like high costs and low throughput. By reducing sequencing sample size for decoding…

Information Theory · Computer Science 2025-04-22 Ruiying Cao , Xin Chen

To overcome the bottleneck of classical path planning schemes in solving NP problems and address the predicament faced by current mainstream quantum path planning frameworks in the Noisy Intermediate-Scale Quantum (NISQ) era, this study…

Quantum Physics · Physics 2025-10-10 Jun Liu

De novo genome assembly focuses on finding connections between a vast amount of short sequences in order to reconstruct the original genome. The central problem of genome assembly could be described as finding a Hamiltonian path through a…

Machine Learning · Computer Science 2020-11-11 Lovro Vrček , Petar Veličković , Mile Šikić

In this paper we have proposed a method that uses chaotic logistic mapping and DNA encoding to encrypt the image. A 32 bit ASCII private key is used to diffuse the image. The results demonstrated clearly show that encryption algorithm based…

Cryptography and Security · Computer Science 2020-03-17 Sakshi Patel , Bharath K P , Rajesh Kumar Muthu

Quantum Annealing (QA) is a computational framework where a quantum system's continuous evolution is used to find the global minimum of an objective function over an unstructured search space. It can be seen as a general metaheuristic for…

Quantum Physics · Physics 2022-02-04 Arthur Braida , Simon Martiel , Ioan Todinca

Gene annotation has traditionally required direct comparison of DNA sequences between an unknown gene and a database of known ones using string comparison methods. However, these methods do not provide useful information when a gene does…

Machine Learning · Computer Science 2019-09-17 James K. Senter , Taylor M. Royalty , Andrew D. Steen , Amir Sadovnik

Combinatorial optimization is among the main applications envisioned for near-term and fault-tolerant quantum computers. In this work, we consider a well-studied quantum algorithm for combinatorial optimization: the Quantum Approximate…

Quantum Physics · Physics 2020-11-12 Sami Boulebnane

Direction-of-arrival (DOA) estimation is widely applied in acoustic source localization. A multi-frequency model is suitable for characterizing the broadband structure in acoustic signals. In this paper, the continuous (gridless) DOA…

Signal Processing · Electrical Eng. & Systems 2023-03-22 Yifan Wu , Michael B. Wakin , Peter Gerstoft

Sample average approximation (SAA) is a technique for obtaining approximate solutions to stochastic programs that uses the average from a random sample to approximate the expected value that is being optimized. Since the outcome from…

Optimization and Control · Mathematics 2026-01-22 Harshit Kothari , James R. Luedtke