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AI technology has made remarkable achievements in computational pathology (CPath), especially with the help of deep neural networks. However, the network performance is highly related to architecture design, which commonly requires human…

Computer Vision and Pattern Recognition · Computer Science 2021-08-17 Sheyang Tang , Mahdi S. Hosseini , Lina Chen , Sonal Varma , Corwyn Rowsell , Savvas Damaskinos , Konstantinos N. Plataniotis , Zhou Wang

Deep learning (DL) has shown great potential in digital pathology applications. The robustness of a diagnostic DL-based solution is essential for safe clinical deployment. In this work we evaluate if adding uncertainty estimates for DL…

Machine Learning · Computer Science 2022-05-23 Milda Pocevičiūtė , Gabriel Eilertsen , Sofia Jarkman , Claes Lundström

Medical data often exhibits distribution shifts, which cause test-time performance degradation for deep learning models trained using standard supervised learning pipelines. This challenge is addressed in the field of Domain Generalization…

Computer Vision and Pattern Recognition · Computer Science 2024-11-01 Aleksandr Matsun , Numan Saeed , Fadillah Adamsyah Maani , Mohammad Yaqub

Medical images are usually collected from multiple domains, leading to domain shifts that impair the performance of medical image segmentation models. Domain Generalization (DG) aims to address this issue by training a robust model with…

Image and Video Processing · Electrical Eng. & Systems 2025-06-13 Xi Chen , Zhiqiang Shen , Peng Cao , Jinzhu Yang , Osmar R. Zaiane

Histopathology image embedding is an active research area in computer vision. Most of the embedding models exclusively concentrate on a specific magnification level. However, a useful task in histopathology embedding is to train an…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Milad Sikaroudi , Benyamin Ghojogh , Fakhri Karray , Mark Crowley , H. R. Tizhoosh

In the cancer diagnosis pipeline, digital pathology plays an instrumental role in the identification, staging, and grading of malignant areas on biopsy tissue specimens. High resolution histology images are subject to high variance in…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Vasileios Magoulianitis , Catherine A. Alexander , C. -C. Jay Kuo

There is an emerging sense that the vulnerability of Image Convolutional Neural Networks (CNN), i.e., sensitivity to image corruptions, perturbations, and adversarial attacks, is connected with Texture Bias. This relative lack of Shape Bias…

Computer Vision and Pattern Recognition · Computer Science 2021-09-14 Maruthi Narayanan , Vickram Rajendran , Benjamin Kimia

Deep neural networks often suffer performance drops when test data distribution differs from training data. Domain Generalization (DG) aims to address this by focusing on domain-invariant features or augmenting data for greater diversity.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Nam Duong Tran , Nam Nguyen Phuong , Hieu H. Pham , Phi Le Nguyen , My T. Thai

Digitization of histopathology slides has led to several advances, from easy data sharing and collaborations to the development of digital diagnostic tools. Deep learning (DL) methods for classification and detection have shown great…

Image and Video Processing · Electrical Eng. & Systems 2020-05-25 Apostolia Tsirikoglou , Karin Stacke , Gabriel Eilertsen , Martin Lindvall , Jonas Unger

Visual microscopic study of diseased tissue by pathologists has been the cornerstone for cancer diagnosis and prognostication for more than a century. Recently, deep learning methods have made significant advances in the analysis and…

Image and Video Processing · Electrical Eng. & Systems 2022-09-30 Puria Azadi Moghadam , Sanne Van Dalen , Karina C. Martin , Jochen Lennerz , Stephen Yip , Hossein Farahani , Ali Bashashati

Deep learning models usually suffer from domain shift issues, where models trained on one source domain do not generalize well to other unseen domains. In this work, we investigate the single-source domain generalization problem: training a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-24 Cheng Ouyang , Chen Chen , Surui Li , Zeju Li , Chen Qin , Wenjia Bai , Daniel Rueckert

Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in…

Deep learning has shown remarkable performance in integrating multimodal data for survival prediction. However, existing multimodal methods mainly focus on single cancer types and overlook the challenge of generalization across cancers. In…

Computer Vision and Pattern Recognition · Computer Science 2025-09-01 Jia-Xuan Jiang , Jiashuai Liu , Hongtao Wu , Yifeng Wu , Zhong Wang , Qi Bi , Yefeng Zheng

Existing domain generalization (DG) methods for cross-person generalization tasks often face challenges in capturing intra- and inter-domain style diversity, resulting in domain gaps with the target domain. In this study, we explore a novel…

Machine Learning · Computer Science 2024-07-02 Junru Zhang , Lang Feng , Zhidan Liu , Yuhan Wu , Yang He , Yabo Dong , Duanqing Xu

Medical AI diagnosis including histopathology segmentation has derived benefits from the recent development of deep learning technology. However, deep learning itself requires a large amount of training data and the medical image…

Image and Video Processing · Electrical Eng. & Systems 2025-07-08 Sungrae Hong , Sol Lee , Mun Yong Yi

The use of Deep Learning (DL) based methods in medical histopathology images have been one of the most sought after solutions to classify, segment, and detect diseased biopsy samples. However, given the complex nature of medical datasets…

Computer Vision and Pattern Recognition · Computer Science 2022-02-23 Suvidha Tripathi , Satish Kumar Singh

Pancreatic cancer, characterized by its notable prevalence and mortality rates, demands accurate lesion delineation for effective diagnosis and therapeutic interventions. The generalizability of extant methods is frequently compromised due…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 Jun Li , Yijue Zhang , Haibo Shi , Minhong Li , Qiwei Li , Xiaohua Qian

Deep learning has made significant advancements in supervised learning. However, models trained in this setting often face challenges due to domain shift between training and test sets, resulting in a significant drop in performance during…

Computer Vision and Pattern Recognition · Computer Science 2024-02-08 Lei Qi , Hongpeng Yang , Yinghuan Shi , Xin Geng

Efficiently utilizing discriminative features is crucial for convolutional neural networks to achieve remarkable performance in medical image segmentation and is also important for model generalization across multiple domains, where letting…

Computer Vision and Pattern Recognition · Computer Science 2022-05-16 Ran Gu , Jiangshan Lu , Jingyang Zhang , Wenhui Lei , Xiaofan Zhang , Guotai Wang , Shaoting Zhang

Task-specific deep learning models in histopathology offer promising opportunities for improving diagnosis, clinical research, and precision medicine. However, development of such models is often limited by availability of high-quality…

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