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As deep learning-based systems have become an integral part of everyday life, limitations in their generalization ability have begun to emerge. Machine learning algorithms typically rely on the i.i.d. assumption, meaning that their training…

Computer Vision and Pattern Recognition · Computer Science 2024-07-25 Aristotelis Ballas , Christos Diou

Diffusion Generative Models (DGM) have rapidly surfaced as emerging topics in the field of computer vision, garnering significant interest across a wide array of deep learning applications. Despite their high computational demand, these…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Denisha Thakkar , Vincent Quoc-Huy Trinh , Sonal Varma , Samira Ebrahimi Kahou , Hassan Rivaz , Mahdi S. Hosseini

Deep learning-based methods deliver state-of-the-art performance for solving inverse problems that arise in computational imaging. These methods can be broadly divided into two groups: (1) learn a network to map measurements to the signal…

Image and Video Processing · Electrical Eng. & Systems 2023-10-11 Nebiyou Yismaw , Ulugbek S. Kamilov , M. Salman Asif

Recent years have seen great advancements in the development of deep learning models for histopathology image analysis in digital pathology applications, evidenced by the increasingly common deployment of these models in both research and…

Image and Video Processing · Electrical Eng. & Systems 2022-08-09 Veena Kaustaban , Qinle Ba , Ipshita Bhattacharya , Nahil Sobh , Satarupa Mukherjee , Jim Martin , Mohammad Saleh Miri , Christoph Guetter , Amal Chaturvedi

Deep learning models for medical image analysis easily suffer from distribution shifts caused by dataset artifacts bias, camera variations, differences in the imaging station, etc., leading to unreliable diagnoses in real-world clinical…

Image and Video Processing · Electrical Eng. & Systems 2024-01-09 Siyuan Yan , Chi Liu , Zhen Yu , Lie Ju , Dwarikanath Mahapatra , Brigid Betz-Stablein , Victoria Mar , Monika Janda , Peter Soyer , Zongyuan Ge

Domain shift in digital histopathology can occur when different stains or scanners are used, during stain translation, etc. A deep neural network trained on source data may not generalise well to data that has undergone some domain shift.…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Zeeshan Nisar , Jelica Vasiljević , Pierre Gançarski , Thomas Lampert

Deep learning (DL) models are being deployed at medical centers to aid radiologists for diagnosis of lung conditions from chest radiographs. Such models are often trained on a large volume of publicly available labeled radiographs. These…

Computer Vision and Pattern Recognition · Computer Science 2020-12-22 Abhishek K Dubey , Michael T Young , Christopher Stanley , Dalton Lunga , Jacob Hinkle

Histopathological images are essential for medical diagnosis and treatment planning, but interpreting them accurately using machine learning can be challenging due to variations in tissue preparation, staining and imaging protocols. Domain…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Vaibhav Khamankar , Sutanu Bera , Saumik Bhattacharya , Debashis Sen , Prabir Kumar Biswas

Machine learning techniques used in computer-aided medical image analysis usually suffer from the domain shift problem caused by different distributions between source/reference data and target data. As a promising solution, domain…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Hao Guan , Mingxia Liu

Ki67 is a significant biomarker in the diagnosis and prognosis of cancer, whose index can be evaluated by quantifying its expression in Ki67 immunohistochemistry (IHC) stained images. However, quantitative analysis on multi-source Ki67…

Computer Vision and Pattern Recognition · Computer Science 2021-07-07 Jiatong Cai , Chenglu Zhu , Can Cui , Honglin Li , Tong Wu , Shichuan Zhang , Lin Yang

The appearance of histopathology images depends on tissue type, staining and digitization procedure. These vary from source to source and are the potential causes for domain-shift problems. Owing to this problem, despite the great success…

Computer Vision and Pattern Recognition · Computer Science 2022-08-24 Trinh Thi Le Vuong , Quoc Dang Vu , Mostafa Jahanifar , Simon Graham , Jin Tae Kwak , Nasir Rajpoot

Despite notable advancements, the integration of deep learning (DL) techniques into impactful clinical applications, particularly in the realm of digital histopathology, has been hindered by challenges associated with achieving robust…

Image and Video Processing · Electrical Eng. & Systems 2024-07-04 Sebastian Doerrich , Francesco Di Salvo , Christian Ledig

Deep learning models are routinely employed in computational pathology (CPath) for solving problems of diagnostic and prognostic significance. Typically, the generalization performance of CPath models is analyzed using evaluation protocols…

Image and Video Processing · Electrical Eng. & Systems 2021-06-18 Alex Foote , Amina Asif , Ayesha Azam , Tim Marshall-Cox , Nasir Rajpoot , Fayyaz Minhas

The lack of well-annotated datasets in computational pathology (CPath) obstructs the application of deep learning techniques for classifying medical images. %Since pathologist time is expensive, dataset curation is intrinsically difficult.…

Image and Video Processing · Electrical Eng. & Systems 2022-01-28 Ryan Zhang , Jiadai Zhu , Stephen Yang , Mahdi S. Hosseini , Angelo Genovese , Lina Chen , Corwyn Rowsell , Savvas Damaskinos , Sonal Varma , Konstantinos N. Plataniotis

Cross-site generalizability in medical AI is fundamentally compromised by selection bias, a structural mechanism where patient demographics (e.g., age, severity) non-randomly dictate hospital assignment. Conventional Domain Generalization…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Shaojin Bai , Yuting Su , Weizhi Nie

Domain generalisation in computational histopathology is challenging because the images are substantially affected by differences among hospitals due to factors like fixation and staining of tissue and imaging equipment. We hypothesise that…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Dhananjay Tomar , Alexander Binder , Andreas Kleppe

Domain shift in the field of histopathological imaging is a common phenomenon due to the intra- and inter-hospital variability of staining and digitization protocols. The implementation of robust models, capable of creating generalized…

Computer Vision and Pattern Recognition · Computer Science 2024-12-06 Ilán Carretero , Pablo Meseguer , Rocío del Amor , Valery Naranjo

Domain generalization (DG) is about learning models that generalize well to new domains that are related to, but different from, the training domain(s). It is a fundamental problem in machine learning and has attracted much attention in…

Machine Learning · Computer Science 2023-07-14 Nevin L. Zhang , Kaican Li , Han Gao , Weiyan Xie , Zhi Lin , Zhenguo Li , Luning Wang , Yongxiang Huang

Domain generalization (DG) strives to address distribution shifts across diverse environments to enhance model's generalizability. Current DG approaches are confined to acquiring robust representations with continuous features, specifically…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Shaocong Long , Qianyu Zhou , Xikun Jiang , Chenhao Ying , Lizhuang Ma , Yuan Luo

We tackle the challenging problem of single-source domain generalization (DG) for medical image segmentation, where we train a network on one domain (e.g., CT) and directly apply it to a different domain (e.g., MR) without adapting the…

Computer Vision and Pattern Recognition · Computer Science 2026-04-29 Franz Thaler , Martin Urschler , Mateusz Kozinski , Matthias AF Gsell , Gernot Plank , Darko Stern